{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T06:39:14Z","timestamp":1776321554992,"version":"3.50.1"},"reference-count":38,"publisher":"AACN Publishing","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:sec>\n                  <jats:title>Topic<\/jats:title>\n                  <jats:p>Ketamine is beneficial in clinical settings ranging from procedural sedation to the treatment of chronic pain. This article describes the clinical benefits of ketamine for treatment of acute pain and for sedation of patients undergoing mechanical ventilation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Relevance<\/jats:title>\n                  <jats:p>Ketamine causes analgesic and amnestic effects by noncompetitive inhibition of the N-methyl-D-aspartate receptor and activation of the opioid \u03bc and \u03ba receptors. Unlike other sedatives, ketamine provides analgesia and amnesia without causing hypotension or respiratory depression. Several studies have elucidated the clinical benefits of ketamine. The use of ketamine has extended beyond critical care areas such as the operating room and intensive care units. Nurses must be familiar with optimal clinical scenarios, monitoring parameters, and contraindications of ketamine.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Purpose<\/jats:title>\n                  <jats:p>To highlight the clinical utility and pharmacological properties of ketamine through a literature review. Current studies of ketamine in acute pain and sedation management are summarized.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Content Covered<\/jats:title>\n                  <jats:p>This narrative review describes pharmacological properties, dosing strategies, adminis\u00adtration considerations, and adverse effects of ketamine.<\/jats:p>\n               <\/jats:sec>","DOI":"10.4037\/ccn2020419","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T19:48:20Z","timestamp":1602532100000},"page":"e26-e32","source":"Crossref","is-referenced-by-count":11,"title":["Ketamine for Acute Pain Management and Sedation"],"prefix":"10.4037","volume":"40","author":[{"given":"Kyle","family":"Brown","sequence":"first","affiliation":[{"name":"Kyle Brown is a critical care pharmacy specialist, Memorial Healthcare System, Pembroke Pines, Florida."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calvin","family":"Tucker","sequence":"additional","affiliation":[{"name":"Calvin Tucker is a coordinator, Acute Care Surgery Pharmacy Services, University of Florida Health Shands Hospital, Jacksonville, Florida."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2471","reference":[{"issue":"2","key":"2020101212511839600_b1-0400e26","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/CNQ.0000000000000012","article-title":"Remifentanil, ketamine, and fospropofol: a review of alternative continuous infusion agents for sedation in the critically ill","volume":"37","author":"Mobrien","year":"2014","journal-title":"Crit Care Nurs Q"},{"issue":"6","key":"2020101212511839600_b2-0400e26","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1177\/0885066615620592","article-title":"Ketamine for analgosedation in the intensive care unit: a systematic 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