{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:47:13Z","timestamp":1773323233389,"version":"3.50.1"},"reference-count":31,"publisher":"AACN Publishing","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:sec>\n                  <jats:title>Topic<\/jats:title>\n                  <jats:p>Sleep in the intensive care unit can be poorly consolidated and highly fragmented. This review examines the neurobiology of normal and abnormal sleep, with a focus on the changes that occur in the intensive care unit environment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Relevance<\/jats:title>\n                  <jats:p>Patients in the intensive care unit demonstrate a lack of rapid-eye-movement sleep and an inability to effectively transition from light to deep stages of sleep. These abnormalities can adversely affect hemodynamic parameters and physiological and psychological outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Purpose<\/jats:title>\n                  <jats:p>To describe the brain mechanisms and electroencephalographic characteristics of wakefulness and the different stages of sleep. This review also describes how sleep can be altered by hospitalization in the intensive care unit and how nurses can design interventions that improve sleep and outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Content Covered<\/jats:title>\n                  <jats:p>The review examines sleep mechanisms, including brain electrical activity, regulatory centers in the brain, and circadian and diurnal patterns of sleep and hemodynamic function. Nursing interventions for specific patient risk factors in the intensive care unit are proposed.<\/jats:p>\n               <\/jats:sec>","DOI":"10.4037\/ccn2020432","type":"journal-article","created":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:08:25Z","timestamp":1596240505000},"page":"e1-e6","source":"Crossref","is-referenced-by-count":4,"title":["Sleep Neurobiology and the Critical Care Environment"],"prefix":"10.4037","volume":"40","author":[{"given":"Anne M.","family":"Fink","sequence":"first","affiliation":[{"name":"Anne M. 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