{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T10:06:37Z","timestamp":1787911597119,"version":"build-2784847793"},"reference-count":37,"publisher":"AACN Publishing","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Brugada syndrome is a genetic disorder of cardiac conduction that predisposes patients to spontaneous ventricular arrhythmia and sudden cardiac death. Although Brugada syndrome is one of the most common causes of sudden cardiac death, patients presenting with the syndrome often go misdiagnosed. This error has potentially fatal consequences for patients, who are at risk for sudden cardiac death without appropriate management.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To increase the critical care professional\u2019s knowledge of Brugada syndrome through detailed description of the characteristic electrocardiographic findings, an algorithmic approach to electrocardiogram evaluation, and a case report of a patient with a previously missed diagnosis of Brugada syndrome. The essential concepts of epidemiology, pathophysiology, clinical presentation, risk stratification, and management are reviewed for critical care professionals who may encounter patients with the syndrome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Diagnosis<\/jats:title>\n                  <jats:p>Patients typically present with syncope or cardiac arrest and an abnormal electrocardiographic finding of ST-segment elevation in the precordial leads. The diagnosis of Brugada syndrome centers on identification of its electrocardiographic characteristics by critical care professionals who routinely evaluate electrocardiograms. Critical care professionals, especially nurses and advanced practice nurses, should be proficient in recognizing the electrocardiographic appearance of Brugada syndrome and initiating appropriate management.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Interventions<\/jats:title>\n                  <jats:p>Management strategies include prevention of sudden cardiac death through lifestyle modification and placement of an implantable cardioverter-defibrillator. Critical care professionals should be aware of commonly used medications that may exacerbate ventricular arrhythmia and place patients at risk for sudden cardiac death.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Increased awareness of Brugada syndrome among critical care professionals can decrease patient morbidity and mortality.<\/jats:p>\n               <\/jats:sec>","DOI":"10.4037\/ccn2021499","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T14:37:17Z","timestamp":1633099037000},"page":"15-22","source":"Crossref","is-referenced-by-count":3,"title":["Brugada Syndrome: Fatal Consequences of a Must-Not-Miss Diagnosis"],"prefix":"10.4037","volume":"41","author":[{"suffix":"Jr","given":"L. Douglas","family":"Smith","sequence":"first","affiliation":[{"name":"L. Douglas Smith Jr is an acute care nurse practitioner at TriStar Centennial Medical Center, Nashville, Tennessee, and an instructor of nursing at Vanderbilt University, Nashville."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Gast","sequence":"additional","affiliation":[{"name":"Sarah Gast is an assistant professor of nursing at Vanderbilt University."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle F.","family":"Guy","sequence":"additional","affiliation":[{"name":"Danielle F. Guy is an adult-gerontology acute care nurse practitioner at Vanderbilt University Medical Center."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2471","reference":[{"issue":"6","key":"2021100102045956100_b1-0410015","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/0735-1097(92)90253-J","article-title":"Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. 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