{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T04:12:21Z","timestamp":1648527141943},"reference-count":48,"publisher":"AACN Publishing","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"\n Background<\/jats:title>\n Multisystem inflammatory syndrome in children is a new syndrome that has been hypothesized to be connected with the COVID-19 pandemic. Children are presenting\u2014likely after SARS-CoV-2 infection or exposure\u2014with vague symptoms including fever, gastrointestinal distress, and\/or rash.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To review what is currently known about multisystem inflammatory syndrome in children, including physiology, signs and symptoms, laboratory and imaging findings, treatment options, and nursing considerations in critical care settings.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This integrative review was conducted using the keywords multisystem inflammatory syndrome in children, Kawasaki-like syndrome, COVID, COVID-19, and SARS-CoV-2. Initially, 324 articles were found. All were screened, and 34 were included. Eight articles were added after hand-searching and weekly literature searches were conducted.<\/jats:p>\n <\/jats:sec>\n \n Data Synthesis<\/jats:title>\n Multisystem inflammatory syndrome in children is a newly identified syndrome, thus information on diagnosis, treatment, and outcomes is available but evolving. Many aspects of nursing care are important to consider with regard to this illness, including COVID precautions, physical assessments, medication administration, and timing of blood sampling for laboratory testing as well as other standard intensive care unit considerations. Providing anticipatory guidance and support to patients and their families is also important.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Critical care nurses must remain informed about advances in the care of patients with multisystem inflammatory syndrome in children, as these patients are often seen in critical care environments because of their high risk of cardiovascular failure.<\/jats:p>\n <\/jats:sec>","DOI":"10.4037\/ccn2021964","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T21:19:17Z","timestamp":1634764757000},"page":"13-22","source":"Crossref","is-referenced-by-count":0,"title":["Multisystem Inflammatory Syndrome in Children in the Critical Care Setting"],"prefix":"10.4037","volume":"42","author":[{"given":"Kristin","family":"Atlas","sequence":"first","affiliation":[{"name":"Kristin Atlas is a clinical nurse specialist in the infant transitional care unit, Children\u2019s Hospital of Philadelphia, and a clinical instructor for the undergraduate BSN program, University of Pennsylvania School of Nursing, Philadelphia, Pennsylvania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica Strohm","family":"Farber","sequence":"additional","affiliation":[{"name":"Jessica Strohm Farber is a pediatric critical care nurse practitioner, Children\u2019s Hospital of Philadelphia, and program director of the pediatric acute care and neonatal nurse practitioner programs, University of Pennsylvania School of Nursing."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerry","family":"Shields","sequence":"additional","affiliation":[{"name":"Kerry Shields is a pediatric acute care nurse practitioner in the pediatric intensive care unit and progressive care unit, Children\u2019s Hospital of Philadelphia, and associate program director of the pediatric acute care nurse practitioner program, University of Pennsylvania School of Nursing."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Lebet","sequence":"additional","affiliation":[{"name":"Ruth Lebet is a nurse-scientist in the Center for Nursing Research and Evidence-Based Practice, Children\u2019s Hospital of Philadelphia, and lecturer, University of Pennsylvania School of Nursing."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2471","reference":[{"issue":"1","key":"2022020100000929100_b1-0420013","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1161\/CIRCULATIONAHA.120.050166","article-title":"Striking similarities of multisystem inflammatory syndrome in children and a myocarditis-like syndrome in adults: overlapping manifestations of COVID-19","volume":"143","author":"Most","year":"2021","journal-title":"Circulation"},{"issue":"9","key":"2022020100000929100_b2-0420013","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/S2352-4642(20)30215-7","article-title":"Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the UK: a multi-centre observational study","volume":"4","author":"Davies","year":"2020","journal-title":"Lancet Child Adolesc Health"},{"key":"2022020100000929100_b3-0420013","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jpeds.2020.10.026","article-title":"Multisystem inflammatory syndrome in children: survey of protocols for early hospital evaluation and management","volume":"229","author":"Dove","year":"2021","journal-title":"J Pediatr"},{"issue":"3","key":"2022020100000929100_b4-0420013","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1093\/jpids\/piaa069","article-title":"Multisystem inflammatory syndrome in children during the coronavirus 2019 pandemic: a case series","volume":"9","author":"Chiotos","year":"2020","journal-title":"J Pediatric Infect Dis Soc"},{"issue":"4","key":"2022020100000929100_b5-0420013","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1056\/NEJMoa2021680","article-title":"Multisystem inflammatory syndrome in U.S. children and adolescents","volume":"383","author":"Feldstein","year":"2020","journal-title":"N Engl J Med"},{"key":"2022020100000929100_b6-0420013","unstructured":"Centers for Disease Control and Prevention\n . 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