{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T12:07:14Z","timestamp":1747224434989,"version":"3.40.5"},"reference-count":0,"publisher":"Sri Lanka Journals Online","issue":"1","license":[{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ceylon Med. J."],"abstract":"<jats:p>Background: The clinical presentation of hypopituitarism varies from asymptomatic to circulatory compromise. The late diagnosis may cause significant mortality and morbidity. There is scant data on the clinical profile.Method: A cross-sectional descriptive analysis was carried out on diagnosed children with hypopituitarism at the endocrinology unit of Lady Ridgeway Hospital for Children, Sri Lanka, from 2013-2021. The presence and progression of pituitary hormonal deficiency were ascertained.Results: Out of the total 94 children with hypopituitarism, 52 had congenital hypopituitarism with a median presenting age of 5.86 years (IQR 3-9). Short stature was the commonest presentation (59.6%). Multiple pituitary hormone deficiency (MPHD) was seen in 27 (51.91%). MPHD was associated with the presence of postnatal risk factors (OR 2.036, 95% CI 1.94-3.786) and MRI Imaging abnormalities in hypothalamic-pituitary morphogenesis (OR 1.768, 95% CI 1.087-2.874). 90.4% with GHD, 46.2% with ACTH deficiency, and 40.4% with TSH deficiency had the mean age of presentation 6.54 years, 6.11 years, and 5.56 years respectively. Of the children above 13 years, 57% showed hypogonadism. Hypoplastic anterior pituitary (40.4%) was the commonest MRI abnormality. Out of the 42 children with brain tumours, 25 (59.52%) had craniopharyngioma, and 13 (31%) had Medulloblastoma, while MPHD was seen in 32 (76.2%). Hormone deficiency at the presentation was seen in 57.1%.Conclusion: Comprehensive evaluation and periodic screening are mandatory for the timely diagnosis of MPHD.<\/jats:p>","DOI":"10.4038\/cmj.v68i1.9502","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T05:43:16Z","timestamp":1700113396000},"page":"12-17","source":"Crossref","is-referenced-by-count":1,"title":["Clinical characteristics of pituitary hormone deficiency in children: A single centre experience"],"prefix":"10.4038","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3015-4161","authenticated-orcid":false,"given":"Balagamage Chamila","family":"Lakmini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Himali Erandathie","family":"Ratnayake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navoda","family":"Atapattu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2473","published-online":{"date-parts":[[2023,11,16]]},"container-title":["Ceylon Medical Journal"],"original-title":[],"link":[{"URL":"https:\/\/account.cmj.sljol.info\/index.php\/sljo-j-cmj\/article\/download\/9502\/6861","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/account.cmj.sljol.info\/index.php\/sljo-j-cmj\/article\/download\/9502\/6861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T05:43:25Z","timestamp":1700113405000},"score":1,"resource":{"primary":{"URL":"https:\/\/account.cmj.sljol.info\/index.php\/sljo-j-cmj\/article\/view\/9502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,16]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,11,16]]}},"URL":"https:\/\/doi.org\/10.4038\/cmj.v68i1.9502","relation":{},"ISSN":["2386-1274","0009-0875"],"issn-type":[{"type":"electronic","value":"2386-1274"},{"type":"print","value":"0009-0875"}],"subject":[],"published":{"date-parts":[[2023,11,16]]}}}