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PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18279766&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1016\/j.joca.2007.12.013","DOI":"10.1016\/j.joca.2008.04.019"},{"key":"ref=28","unstructured":"Nasjonalt kunnskapssenter for helsetjenesten. Effekt av fysioterapi ved kneleddsartrose, begrenset til elektroterapi og \u00f8velsesbehandling. Rapport nr. 7\/2004. www.kunnskapssenteret.no\/binary?download=true&id=5251 (2.9.2010)."},{"key":"ref=29","doi-asserted-by":"crossref","unstructured":"Bennell KL, Hunt MA, Wrigley TV et al. Role of muscle in the genesis and management of knee osteoarthritis. Rheum Dis Clin North Am 2008; 34: 731\u2009\u2013\u200954. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18687280&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1016\/j.rdc.2008.05.005","DOI":"10.1016\/j.rdc.2008.05.005"},{"key":"ref=30","doi-asserted-by":"crossref","unstructured":"Lloyd DG, Buchanan TS. 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PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18405470&dopt=Abstract","DOI":"10.3310\/hta12110"},{"key":"ref=44","doi-asserted-by":"crossref","unstructured":"Kvien TK, Br\u00f8rs O, Staff PH et al. Improved cost-effectiveness ratio with a patient self-adjusted naproxen dosing regimen in osteoarthritis treatment. Scand J Rheumatol 1991; 20: 280\u2009\u2013\u20097. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1925416&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.3109\/03009749109096801","DOI":"10.3109\/03009749109096801"},{"key":"ref=45","unstructured":"Statens legemiddelverk. Betennelsesdempende midler og mulig risiko for hjerte- og karbivirkninger. www.legemiddelverket.no\/templates\/InterPage____32960.aspx (2.9.2010)."},{"key":"ref=46","doi-asserted-by":"crossref","unstructured":"Chan FK, Wong VW, Suen BY et al. Combination of a cyclo-oxygenase-2 inhibitor and a proton-pump inhibitor for prevention of recurrent ulcer bleeding in patients at very high risk: a double-blind, randomised trial. Lancet 2007; 369: 1621\u2009\u2013\u20096. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17499604&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1016\/S0140-6736(07)60749-1","DOI":"10.1016\/S0140-6736(07)60749-1"},{"key":"ref=47","doi-asserted-by":"crossref","unstructured":"McGettigan P, Henry D. Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2. JAMA 2006; 296: 1633\u2009\u2013\u200944. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16968831&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1001\/jama.296.13.jrv60011","DOI":"10.1001\/jama.296.13.jrv60011"},{"key":"ref=48","doi-asserted-by":"crossref","unstructured":"Felson DT. Developments in the clinical understanding of osteoarthritis. Arthritis Res Ther 2009; 11: 203. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19232065&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1186\/ar2531","DOI":"10.1186\/ar2531"},{"key":"ref=49","doi-asserted-by":"crossref","unstructured":"N\u00fcesch E, Rutjes AW, Husni E et al. Oral or transdermal opioids for osteoarthritis of the knee or hip. Cochrane Database Syst Rev 2009; nr. 4: CD003115.","DOI":"10.1002\/14651858.CD003115.pub3"},{"key":"ref=50","doi-asserted-by":"crossref","unstructured":"Reginster JY, Deroisy R, Rovati LC et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet 2001; 357: 251\u2009\u2013\u20096. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11214126&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1016\/S0140-6736(00)03610-2","DOI":"10.1016\/S0140-6736(00)03610-2"},{"key":"ref=51","doi-asserted-by":"crossref","unstructured":"Rozendaal RM, Koes BW, van Osch GJ et al. Effect of glucosamine sulfate on hip osteoarthritis: a randomized trial. Ann Intern Med 2008; 148: 268\u2009\u2013\u200977. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18283204&dopt=Abstract","DOI":"10.7326\/0003-4819-148-4-200802190-00005"},{"key":"ref=52","doi-asserted-by":"crossref","unstructured":"Clegg DO, Reda DJ, Harris CL et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006; 354: 795\u2009\u2013\u2009808. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16495392&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1056\/NEJMoa052771","DOI":"10.1056\/NEJMoa052771"},{"key":"ref=53","doi-asserted-by":"crossref","unstructured":"Sawitzke AD, Shi H, Finco MF et al. The effect of glucosamine and\/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine\/chondroitin arthritis intervention trial. Arthritis Rheum 2008; 58: 3183\u2009\u2013\u200991. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18821708&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1002\/art.23973","DOI":"10.1002\/art.23973"},{"key":"ref=54","doi-asserted-by":"crossref","unstructured":"Bellamy N, Campbell J, Robinson V et al. Intraarticular corticosteroid for treatment of osteoarthritis of the knee. Cochrane Database Syst Rev 2006; 2: CD005328. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16625636&dopt=Abstract","DOI":"10.1002\/14651858.CD005328"},{"key":"ref=55","doi-asserted-by":"crossref","unstructured":"Moseley JB, O\u2019Malley K, Petersen NJ et al. A controlled trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med 2002; 347: 81\u2009\u2013\u20098. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12110735&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1056\/NEJMoa013259","DOI":"10.1056\/NEJMoa013259"},{"key":"ref=56","doi-asserted-by":"crossref","unstructured":"Knutsen G, Drogset JO, Engebretsen L et al. A randomized trial comparing autologous chondrocyte implantation with microfracture. Findings at five years. J Bone Joint Surg Am 2007; 89: 2105\u2009\u2013\u200912. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17908884&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.2106\/JBJS.G.00003","DOI":"10.2106\/JBJS.G.00003"},{"key":"ref=57","doi-asserted-by":"crossref","unstructured":"Amendola A, Bonasia DE. Results of high tibial osteotomy: review of the literature. Int Orthop 2010; 34: 155\u2009\u2013\u200960. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19838706&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1007\/s00264-009-0889-8","DOI":"10.1007\/s00264-009-0889-8"},{"key":"ref=58","doi-asserted-by":"crossref","unstructured":"Yasunaga Y, Ochi M, Shimogaki K et al. Rotational acetabular osteotomy for hip dysplasia: 61 hips followed for 8\u2009\u2013\u200915 years. Acta Orthop Scand 2004; 75: 10\u2009\u2013\u20095. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15022799&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1080\/00016470410001708020","DOI":"10.1080\/00016470410001708020"},{"key":"ref=59","doi-asserted-by":"crossref","unstructured":"Iwase T, Hasegawa Y, Kawamoto K et al. Twenty years\u2019 followup of intertrochanteric osteotomy for treatment of the dysplastic hip. Clin Orthop Relat Res 1996; 331: 245\u2009\u2013\u200955. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8895646&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1097\/00003086-199610000-00035","DOI":"10.1097\/00003086-199610000-00035"},{"key":"ref=60","doi-asserted-by":"crossref","unstructured":"Sponseller PD, McBeath AA, Perpich M. Hip arthrodesis in young patients. A long-term follow-up study. J Bone Joint Surg Am 1984; 66: 853\u2009\u2013\u20099. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6234319&dopt=Abstract","DOI":"10.2106\/00004623-198466060-00005"},{"key":"ref=61","doi-asserted-by":"crossref","unstructured":"Callaghan JJ, Brand RA, Pedersen DR. Hip arthrodesis. A long-term follow-up. J Bone Joint Surg Am 1985; 67: 1328\u2009\u2013\u200935. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=4077903&dopt=Abstract","DOI":"10.2106\/00004623-198567090-00004"},{"key":"ref=62","doi-asserted-by":"crossref","unstructured":"Espehaug B, Furnes O, Engesaeter LB et al. 18 years of results with cemented primary hip prostheses in the Norwegian Arthroplasty Register: concerns about some newer implants. Acta Orthop 2009; 80: 402\u2009\u2013\u200912. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19857178&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.3109\/17453670903161124","DOI":"10.3109\/17453670903161124"},{"key":"ref=63","doi-asserted-by":"crossref","unstructured":"Garellick G, Malchau H, Herberts P. Survival of hip replacements. A comparison of a randomized trial and a registry. Clin Orthop Relat Res 2000; 375: 157\u2009\u2013\u200967. 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