{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T23:53:04Z","timestamp":1781653984851,"version":"3.54.5"},"reference-count":39,"publisher":"Norwegian Medical Association","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tidsskr Nor Legeforen","Tidsskriftet"],"published-print":{"date-parts":[[2013,8,6]]},"DOI":"10.4045\/tidsskr.12.0873","type":"journal-article","created":{"date-parts":[[2013,8,9]],"date-time":"2013-08-09T04:22:14Z","timestamp":1376022134000},"page":"1449-52","source":"Crossref","is-referenced-by-count":3,"title":["Alzheimers sykdom og genetikk"],"prefix":"10.4045","volume":"133","author":[{"given":"Arvid","family":"Rongve","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dag","family":"\u00c5rsland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Graff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2479","reference":[{"key":"ref=1","doi-asserted-by":"crossref","unstructured":"Hjort PF, Waaler HT. Demens frem mot 2050. Tidsskr Nor Legeforen 2010; 130: 1356\u2009\u2013\u20098. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=20596119&dopt=Abstract","DOI":"10.4045\/tidsskr.09.1433"},{"key":"ref=2","doi-asserted-by":"crossref","unstructured":"Aarsland D, Rongve A, Nore SP et al. Frequency and case identification of dementia with Lewy bodies using the revised consensus criteria. Dement Geriatr Cogn Disord 2008; 26: 445\u2009\u2013\u200952. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18974647&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1159\/000165917","DOI":"10.1159\/000165917"},{"key":"ref=3","doi-asserted-by":"crossref","unstructured":"Goldman JS, Hahn SE, Catania JW et al. Genetic counseling and testing for Alzheimer disease: joint practice guidelines of the American College of Medical Genetics and the National Society of Genetic Counselors. Genet Med 2011; 13: 597\u2009\u2013\u2009605. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21577118&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1097\/GIM.0b013e31821d69b8","DOI":"10.1097\/GIM.0b013e31821d69b8"},{"key":"ref=4","doi-asserted-by":"crossref","unstructured":"Bertram L, McQueen MB, Mullin K et al. Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet 2007; 39: 17\u2009\u2013\u200923. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17192785&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1038\/ng1934","DOI":"10.1038\/ng1934"},{"key":"ref=5","unstructured":"Engedal K, Haugen PK, Br\u00e6khus A. Demens \u2013 fakta og utfordringer: en l\u00e6rebok. 5. utg. Oslo: Aldring & Helse, 2009."},{"key":"ref=6","doi-asserted-by":"crossref","unstructured":"Ritchie K, Carri\u00e8re I, Ritchie CW et al. Designing prevention programmes to reduce incidence of dementia: prospective cohort study of modifiable risk factors. BMJ 2010; 341: c3885. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=20688841&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1136\/bmj.c3885","DOI":"10.1136\/bmj.c3885"},{"key":"ref=7","doi-asserted-by":"crossref","unstructured":"Barnes DE, Yaffe K. The projected effect of risk factor reduction on Alzheimer\u2019s disease prevalence. Lancet Neurol 2011; 10: 819\u2009\u2013\u200928. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21775213&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1016\/S1474-4422(11)70072-2","DOI":"10.1016\/S1474-4422(11)70072-2"},{"key":"ref=8","doi-asserted-by":"crossref","unstructured":"Bergem AL, Engedal K, Kringlen E. The role of heredity in late-onset Alzheimer disease and vascular dementia. A twin study. Arch Gen Psychiatry 1997; 54: 264\u2009\u2013\u200970. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9075467&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1001\/archpsyc.1997.01830150090013","DOI":"10.1001\/archpsyc.1997.01830150090013"},{"key":"ref=9","doi-asserted-by":"crossref","unstructured":"Gatz M, Pedersen NL, Berg S et al. Heritability for Alzheimer\u2019s disease: the study of dementia in Swedish twins. J Gerontol A Biol Sci Med Sci 1997; 52: M117\u2009\u2013\u200925. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9060980&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1093\/gerona\/52A.2.M117","DOI":"10.1093\/gerona\/52A.2.M117"},{"key":"ref=10","doi-asserted-by":"crossref","unstructured":"Kiejna A, Frydecka D, Adamowski T et al. Epidemiological studies of cognitive impairment and dementia across Eastern and Middle European countries (epidemiology of dementia in Eastern and Middle European Countries). Int J Geriatr Psychiatry 2011; 26: 111\u2009\u2013\u20097. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=20632300&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1002\/gps.2511","DOI":"10.1002\/gps.2511"},{"key":"ref=11","unstructured":"Graff AC. \u00c4rftlighet vid Alzheimer's sjukdom. Nordisk geriatrik 2005; 1: 4\u2009\u2013\u20096."},{"key":"ref=12","doi-asserted-by":"crossref","unstructured":"van Duijn CM, Clayton D, Chandra V et al. Familial aggregation of Alzheimer\u2019s disease and related disorders: a collaborative re-analysis of case-control studies. Int J Epidemiol 1991; 20 (suppl 2): S13\u2009\u2013\u200920. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1833349&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1093\/ije\/20.Supplement_2.S13","DOI":"10.1093\/ije\/20.Supplement_2.S13"},{"key":"ref=13","doi-asserted-by":"crossref","unstructured":"Zhou ZD, Chan CH, Ma QH et al. The roles of amyloid precursor protein (APP) in neurogenesis: Implications to pathogenesis and therapy of Alzheimer disease. Cell Adhes Migr 2011; 5: 280\u2009\u2013\u200992. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21785276&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.4161\/cam.5.4.16986","DOI":"10.4161\/cam.5.4.16986"},{"key":"ref=14","doi-asserted-by":"crossref","unstructured":"Finder VH, Glockshuber R. Amyloid-beta aggregation. Neurodegener Dis 2007; 4: 13\u2009\u2013\u200927. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17429215&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1159\/000100355","DOI":"10.1159\/000100355"},{"key":"ref=15","doi-asserted-by":"crossref","unstructured":"Zotova E, Nicoll JA, Kalaria R et al. Inflammation in Alzheimer\u2019s disease: relevance to pathogenesis and therapy. Alzheimers Res Ther 2010; 2: 1. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=20122289&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1186\/alzrt24","DOI":"10.1186\/alzrt24"},{"key":"ref=16","unstructured":"Galimberti D, Scarpini E. Genetics and biology of Alzheimer\u2019s disease and frontotemporal lobar degeneration. Int J Clin Exp Med 2010; 3: 129\u2009\u2013\u200943. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=20607039&dopt=Abstract"},{"key":"ref=17","doi-asserted-by":"crossref","unstructured":"Zigman WB, Lott IT. Alzheimer\u2019s disease in Down syndrome: neurobiology and risk. Ment Retard Dev Disabil Res Rev 2007; 13: 237\u2009\u2013\u200946. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17910085&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1002\/mrdd.20163","DOI":"10.1002\/mrdd.20163"},{"key":"ref=18","doi-asserted-by":"crossref","unstructured":"Avramopoulos D. Genetics of Alzheimer\u2019s disease: recent advances. Genome Med 2009; 1: 34. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19341505&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1186\/gm34","DOI":"10.1186\/gm34"},{"key":"ref=19","doi-asserted-by":"crossref","unstructured":"Goate A, Chartier-Harlin MC, Mullan M et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer\u2019s disease. Nature 1991; 349: 704\u2009\u2013\u20096. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1671712&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1038\/349704a0","DOI":"10.1038\/349704a0"},{"key":"ref=20","doi-asserted-by":"crossref","unstructured":"Sherrington R, Rogaev EI, Liang Y et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer\u2019s disease. Nature 1995; 375: 754\u2009\u2013\u200960. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7596406&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1038\/375754a0","DOI":"10.1038\/375754a0"},{"key":"ref=21","doi-asserted-by":"crossref","unstructured":"Levy-Lahad E, Wasco W, Poorkaj P et al. Candidate gene for the chromosome 1 familial Alzheimer\u2019s disease locus. Science 1995; 269: 973\u2009\u2013\u20097. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7638622&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1126\/science.7638622","DOI":"10.1126\/science.7638622"},{"key":"ref=22","doi-asserted-by":"crossref","unstructured":"Jonsson T, Atwal JK, Steinberg S et al. A mutation in APP protects against Alzheimer\u2019s disease and age-related cognitive decline. Nature 2012; 488: 96\u2009\u2013\u20099. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22801501&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1038\/nature11283","DOI":"10.1038\/nature11283"},{"key":"ref=23","doi-asserted-by":"crossref","unstructured":"Mangialasche F, Solomon A, Winblad B et al. Alzheimer\u2019s disease: clinical trials and drug development. Lancet Neurol 2010; 9: 702\u2009\u2013\u200916. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=20610346&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1016\/S1474-4422(10)70119-8","DOI":"10.1016\/S1474-4422(10)70119-8"},{"key":"ref=24","doi-asserted-by":"crossref","unstructured":"Russell MB. Genetics of dementia. Acta Neurol Scand Suppl 2010; 122: 58\u2009\u2013\u200961. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=20586737&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1111\/j.1600-0404.2010.01377.x","DOI":"10.1111\/j.1600-0404.2010.01377.x"},{"key":"ref=25","doi-asserted-by":"crossref","unstructured":"Bekris LM, Yu CE, Bird TD et al. Genetics of Alzheimer disease. J Geriatr Psychiatry Neurol 2010; 23: 213\u2009\u2013\u200927. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21045163&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1177\/0891988710383571","DOI":"10.1177\/0891988710383571"},{"key":"ref=26","doi-asserted-by":"crossref","unstructured":"Olgiati P, Politis AM, Papadimitriou GN et al. Genetics of late-onset Alzheimer's disease: update from the alzgene database and analysis of shared pathways. Int J Alzheimers Dis 2011; 2011: 832379.","DOI":"10.4061\/2011\/832379"},{"key":"ref=27","doi-asserted-by":"crossref","unstructured":"Corder EH, Saunders AM, Strittmatter WJ et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer\u2019s disease in late onset families. Science 1993; 261: 921\u2009\u2013\u20093. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8346443&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1126\/science.8346443","DOI":"10.1126\/science.8346443"},{"key":"ref=28","doi-asserted-by":"crossref","unstructured":"D\u2019Onofrio G, Panza F, Seripa D et al. The APOE polymorphism in Alzheimer\u2019s disease patients with neuropsychiatric symptoms and syndromes. Int J Geriatr Psychiatry 2011; 26: 1062\u2009\u2013\u200970. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21905100&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1002\/gps.2644","DOI":"10.1002\/gps.2644"},{"key":"ref=29","doi-asserted-by":"crossref","unstructured":"Hollingworth P, Harold D, Jones L et al. Alzheimer\u2019s disease genetics: current knowledge and future challenges. Int J Geriatr Psychiatry 2011; 26: 793\u2009\u2013\u2009802. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=20957767&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1002\/gps.2628","DOI":"10.1002\/gps.2628"},{"key":"ref=30","doi-asserted-by":"crossref","unstructured":"Roberts JS, Cupples LA, Relkin NR et al. Genetic risk assessment for adult children of people with Alzheimer\u2019s disease: the Risk Evaluation and Education for Alzheimer\u2019s Disease (REVEAL) study. J\u00a0Geriatr Psychiatry Neurol 2005; 18: 250\u2009\u2013\u20095. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16306249&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1177\/0891988705281883","DOI":"10.1177\/0891988705281883"},{"key":"ref=31","doi-asserted-by":"crossref","unstructured":"Genin E, Hannequin D, Wallon D et al. APOE and Alzheimer disease: a major gene with semi-dominant inheritance. Mol Psychiatry 2011; 16: 903\u2009\u2013\u20097. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21556001&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1038\/mp.2011.52","DOI":"10.1038\/mp.2011.52"},{"key":"ref=32","doi-asserted-by":"crossref","unstructured":"Hollingworth P, Harold D, Sims R et al. Common variants at ABCA7, MS4A6A\/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer\u2019s disease. Nat Genet 2011; 43: 429\u2009\u2013\u200935. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21460840&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1038\/ng.803","DOI":"10.1038\/ng.803"},{"key":"ref=33","doi-asserted-by":"crossref","unstructured":"Harold D, Abraham R, Hollingworth P et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer\u2019s disease. Nat Genet 2009; 41: 1088\u2009\u2013\u200993. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19734902&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1038\/ng.440","DOI":"10.1038\/ng.440"},{"key":"ref=34","doi-asserted-by":"crossref","unstructured":"Naj AC, Jun G, Beecham GW et al. Common variants at MS4A4\/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer\u2019s disease. Nat Genet 2011; 43: 436\u2009\u2013\u200941. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21460841&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1038\/ng.801","DOI":"10.1038\/ng.801"},{"key":"ref=35","doi-asserted-by":"crossref","unstructured":"Jonsson T, Stefansson H, Steinberg S et al. Variant of TREM2 associated with the risk of Alzheimer\u2019s disease. N Engl J Med 2013; 368: 107\u2009\u2013\u200916. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23150908&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1056\/NEJMoa1211103","DOI":"10.1056\/NEJMoa1211103"},{"key":"ref=36","doi-asserted-by":"crossref","unstructured":"Guerreiro R, Wojtas A, Bras J et al. TREM2 variants in Alzheimer\u2019s disease. N Engl J Med 2013; 368: 117\u2009\u2013\u200927. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23150934&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1056\/NEJMoa1211851","DOI":"10.1056\/NEJMoa1211851"},{"key":"ref=37","doi-asserted-by":"crossref","unstructured":"Thambisetty M, Simmons A, Velayudhan L et al. Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psychiatry 2010; 67: 739\u2009\u2013\u200948. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=20603455&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1001\/archgenpsychiatry.2010.78","DOI":"10.1001\/archgenpsychiatry.2010.78"},{"key":"ref=38","doi-asserted-by":"crossref","unstructured":"Neumann H, Daly MJ. Variant TREM2 as risk factor for Alzheimer\u2019s disease. N Engl J Med 2013; 368: 182\u2009\u2013\u20094. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23151315&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1056\/NEJMe1213157","DOI":"10.1056\/NEJMe1213157"},{"key":"ref=39","doi-asserted-by":"crossref","unstructured":"Morgan K. The three new pathways leading to Alzheimer\u2019s disease. Neuropathol Appl Neurobiol 2011; 37: 353\u2009\u2013\u20097. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21486313&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1111\/j.1365-2990.2011.01181.x","DOI":"10.1111\/j.1365-2990.2011.01181.x"}],"container-title":["Tidsskrift for Den norske legeforening"],"original-title":[],"language":"no","deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T23:00:58Z","timestamp":1781650858000},"score":1,"resource":{"primary":{"URL":"https:\/\/tidsskriftet.no\/2013\/08\/oversiktsartikkel\/alzheimers-sykdom-og-genetikk"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,6]]},"references-count":39,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2013,8,6]]}},"URL":"https:\/\/doi.org\/10.4045\/tidsskr.12.0873","relation":{},"ISSN":["0029-2001","0807-7096"],"issn-type":[{"value":"0029-2001","type":"print"},{"value":"0807-7096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,6]]}}}