{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:53:58Z","timestamp":1781679238390,"version":"3.54.5"},"reference-count":37,"publisher":"Norwegian Medical Association","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tidsskr Nor Legeforen","Tidsskriftet"],"published-print":{"date-parts":[[2016,11,8]]},"DOI":"10.4045\/tidsskr.16.0563","type":"journal-article","created":{"date-parts":[[2016,11,10]],"date-time":"2016-11-10T09:05:16Z","timestamp":1478768716000},"page":"1726-9","source":"Crossref","is-referenced-by-count":6,"title":["Family planning, pregnancy and breastfeeding in multiple sclerosis"],"prefix":"10.4045","volume":"136","author":[{"given":"Trygve","family":"Holm\u00f8y","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8ivind","family":"Torkildsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2479","reference":[{"key":"ref=1","doi-asserted-by":"crossref","unstructured":"O'Gorman C, Lin R, Stankovich J et al. Modelling genetic susceptibility to multiple sclerosis with family data. Neuroepidemiology 2013; 40: 1\u2009\u2013\u200912. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23075677&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1159\/000341902","DOI":"10.1159\/000341902"},{"key":"ref=2","doi-asserted-by":"crossref","unstructured":"L\u00f8ken-Amsrud KI, Lossius A, Torkildsen \u00d8 et al. Milj\u00f8ets betydning ved multippel sklerose. Tidsskr Nor Legeforen 2015; 135: 856\u2009\u2013\u200960. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25991624&dopt=Abstract","DOI":"10.4045\/tidsskr.14.0751"},{"key":"ref=3","doi-asserted-by":"crossref","unstructured":"Munger KL, \u00c5ivo J, Hongell K et al. Vitamin D Status During Pregnancy and Risk of Multiple Sclerosis in Offspring of Women in the Finnish Maternity Cohort. JAMA Neurol 2016; 73: 515\u2009\u2013\u20099. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26953778&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1001\/jamaneurol.2015.4800","DOI":"10.1001\/jamaneurol.2015.4800"},{"key":"ref=4","doi-asserted-by":"crossref","unstructured":"Amato MP, Portaccio E. Fertility, pregnancy and childbirth in patients with multiple sclerosis: impact of disease-modifying drugs. CNS Drugs 2015; 29: 207\u2009\u2013\u200920. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25773609&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1007\/s40263-015-0238-y","DOI":"10.1007\/s40263-015-0238-y"},{"key":"ref=5","doi-asserted-by":"crossref","unstructured":"Roux T, Courtillot C, Debs R et al. Fecundity in women with multiple sclerosis: an observational mono-centric study. J Neurol 2015; 262: 957\u2009\u2013\u200960. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25673128&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1007\/s00415-015-7663-1","DOI":"10.1007\/s00415-015-7663-1"},{"key":"ref=6","doi-asserted-by":"crossref","unstructured":"Hellwig K. Multiple sclerosis and family planning. Neurodegener Dis Manag 2015; 5 (suppl): 39\u2009\u2013\u200942. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26611271&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.2217\/nmt.15.61","DOI":"10.2217\/nmt.15.61"},{"key":"ref=7","doi-asserted-by":"crossref","unstructured":"Sorensen PS, Koch-Henriksen N, Petersen T et al. Recurrence or rebound of clinical relapses after discontinuation of natalizumab therapy in highly active MS patients. J Neurol 2014; 261: 1170\u2009\u2013\u20097. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24728334&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1007\/s00415-014-7325-8","DOI":"10.1007\/s00415-014-7325-8"},{"key":"ref=8","doi-asserted-by":"crossref","unstructured":"Bove R, Alwan S, Friedman JM et al. Management of multiple sclerosis during pregnancy and the reproductive years: a systematic review. Obstet Gynecol 2014; 124: 1157\u2009\u2013\u200968. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25415167&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1097\/AOG.0000000000000541","DOI":"10.1097\/AOG.0000000000000541"},{"key":"ref=9","doi-asserted-by":"crossref","unstructured":"Coyle PK. Management of women with multiple sclerosis through pregnancy and after childbirth. Ther Adv Neurol Disorder 2016; 9: 198\u2009\u2013\u2009210. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27134675&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1177\/1756285616631897","DOI":"10.1177\/1756285616631897"},{"key":"ref=10","doi-asserted-by":"crossref","unstructured":"Vukusic S, Marignier R. Multiple sclerosis and pregnancy in the 'treatment era'. Nat Rev Neurol 2015; 11: 280\u2009\u2013\u20099. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25896084&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1038\/nrneurol.2015.53","DOI":"10.1038\/nrneurol.2015.53"},{"key":"ref=11","doi-asserted-by":"crossref","unstructured":"Thiel S, Langer-Gould A, Rockhoff M et al. Interferon-beta exposure during first trimester is safe in women with multiple sclerosis-A prospective cohort study from the German Multiple Sclerosis and Pregnancy Registry. Mult Scler 2016; 22: 801\u2009\u2013\u20099. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26920382&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1177\/1352458516634872","DOI":"10.1177\/1352458516634872"},{"key":"ref=12","doi-asserted-by":"crossref","unstructured":"Herbstritt S, Langer-Gould A, Rockhoff M et al. Glatiramer acetate during early pregnancy: A prospective cohort study. Mult Scler 2016; 22: 810\u2009\u2013\u20096. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26754804&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1177\/1352458515623366","DOI":"10.1177\/1352458515623366"},{"key":"ref=13","doi-asserted-by":"crossref","unstructured":"Hatcher SE, Waubant E, Nourbakhsh B et al. Rebound Syndrome in Patients With Multiple Sclerosis After Cessation of Fingolimod Treatment. JAMA Neurol 2016; 73: 790\u2009\u2013\u20094. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27135594&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1001\/jamaneurol.2016.0826","DOI":"10.1001\/jamaneurol.2016.0826"},{"key":"ref=14","doi-asserted-by":"crossref","unstructured":"Rasenack M, Derfuss T. Disease activity return after natalizumab cessation in multiple sclerosis. Expert Rev Neurother 2016; 16: 587\u2009\u2013\u200994. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26988737&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1586\/14737175.2016.1168295","DOI":"10.1586\/14737175.2016.1168295"},{"key":"ref=15","unstructured":"Australian Government of Health. Prescribing medicines in pregnancy database. www.tga.gov.au\/prescribing-medicines-pregnancy-database (15.8.2016)."},{"key":"ref=16","unstructured":"National Institutes of Health. Toxnet. https:\/\/toxnet.nlm.nih.gov\/ (15.8.2016)."},{"key":"ref=17","unstructured":"Widnes SF, Bakkeb\u00f8 T. Ikke bruk felleskatalogen for informasjon om legemidler ved graviditet og amming. RELIS. 2014. https:\/\/relis.no\/Publikasjoner\/2014\/Ikke_bruk_Felleskatalogen_for_informasjon_om_legemidler_ved_graviditet_eller_amming\/ (23.6.2016)."},{"key":"ref=18","doi-asserted-by":"crossref","unstructured":"Friend S, Richman S, Bloomgren G et al. Evaluation of pregnancy outcomes from the Tysabri\u00ae (natalizumab) pregnancy exposure registry: a global, observational, follow-up study. BMC Neurol 2016; 16: 150. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27552976&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1186\/s12883-016-0674-4","DOI":"10.1186\/s12883-016-0674-4"},{"key":"ref=19","doi-asserted-by":"crossref","unstructured":"Ebrahimi N, Herbstritt S, Gold R et al. Pregnancy and fetal outcomes following natalizumab exposure in pregnancy. A prospective, controlled observational study. Mult Scler 2015; 21: 198\u2009\u2013\u2009205. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25159275&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1177\/1352458514546790","DOI":"10.1177\/1352458514546790"},{"key":"ref=20","doi-asserted-by":"crossref","unstructured":"Haghikia A, Langer-Gould A, Rellensmann G et al. Natalizumab use during the third trimester of pregnancy. JAMA Neurol 2014; 71: 891\u2009\u2013\u20095. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24821217&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1001\/jamaneurol.2014.209","DOI":"10.1001\/jamaneurol.2014.209"},{"key":"ref=21","doi-asserted-by":"crossref","unstructured":"Zhovtis Ryerson L, Frohman TC, Foley J et al. Extended interval dosing of natalizumab in multiple sclerosis. J Neurol Neurosurg Psychiatry 2016; 87: 885\u2009\u2013\u20099. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26917698&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1136\/jnnp-2015-312940","DOI":"10.1136\/jnnp-2015-312940"},{"key":"ref=22","doi-asserted-by":"crossref","unstructured":"Coles A. Newer therapies for multiple sclerosis. Ann Indian Acad Neurol 2015; 18 (suppl 1): S30\u2009\u2013\u20094. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26538846&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.4103\/0972-2327.164824","DOI":"10.4103\/0972-2327.164824"},{"key":"ref=23","doi-asserted-by":"crossref","unstructured":"de Flon P, Gunnarsson M, Laurell K et al. Reduced inflammation in relapsing-remitting multiple sclerosis after therapy switch to rituximab. Neurology 2016; 87: 141\u2009\u2013\u20097. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=27316241&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1212\/WNL.0000000000002832","DOI":"10.1212\/WNL.0000000000002832"},{"key":"ref=24","doi-asserted-by":"crossref","unstructured":"Thiel S, Langer-Gould A, Rockhoff M et al. Interferon-beta exposure during first trimester is safe in women with multiple sclerosis-A prospective cohort study from the German Multiple Sclerosis and Pregnancy Registry. Mult Scler 2016; 22: 801\u2009\u2013\u20099. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26920382&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1177\/1352458516634872","DOI":"10.1177\/1352458516634872"},{"key":"ref=25","doi-asserted-by":"crossref","unstructured":"Herbstritt S, Langer-Gould A, Rockhoff M et al. Glatiramer acetate during early pregnancy: A prospective cohort study. Mult Scler 2016; 22: 810\u2009\u2013\u20096. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26754804&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1177\/1352458515623366","DOI":"10.1177\/1352458515623366"},{"key":"ref=26","unstructured":"Legemiddelindustrien. Felleskatalogen. www.felleskatalogen.no\/medisin\/sok?sokord=Aubagio (15.9.2016)."},{"key":"ref=27","doi-asserted-by":"crossref","unstructured":"Kieseier BC, Benamor M. Pregnancy outcomes following maternal and paternal exposure to teriflunomide during treatment for relapsing-remitting multiple sclerosis. Neurol Ther 2014; 3: 133\u2009\u2013\u20098. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26000229&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1007\/s40120-014-0020-y","DOI":"10.1007\/s40120-014-0020-y"},{"key":"ref=28","doi-asserted-by":"crossref","unstructured":"Queisser-Luft A, Stolz G, Wiesel A et al. Malformations in newborn: results based on 30,940 infants and fetuses from the Mainz congenital birth defect monitoring system (1990\u2009\u2013\u20091998). Arch Gynecol Obstet 2002; 266: 163\u2009\u2013\u20097. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12197558&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1007\/s00404-001-0265-4","DOI":"10.1007\/s00404-001-0265-4"},{"key":"ref=29","doi-asserted-by":"crossref","unstructured":"Karlsson G, Francis G, Koren G et al. Pregnancy outcomes in the clinical development program of fingolimod in multiple sclerosis. Neurology 2014; 82: 674\u2009\u2013\u200980. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24463630&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1212\/WNL.0000000000000137","DOI":"10.1212\/WNL.0000000000000137"},{"key":"ref=30","doi-asserted-by":"crossref","unstructured":"Jones B. Multiple sclerosis: Study reinforces need for contraception in women taking fingolimod. Nat Rev Neurol 2014; 10: 125. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=24514867&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1038\/nrneurol.2014.22","DOI":"10.1038\/nrneurol.2014.22"},{"key":"ref=31","doi-asserted-by":"crossref","unstructured":"Dahl J, Myhr KM, Daltveit AK et al. Pregnancy, delivery, and birth outcome in women with multiple sclerosis. Neurology 2005; 65: 1961\u2009\u2013\u20093. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16380620&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1212\/01.wnl.0000188898.02018.95","DOI":"10.1212\/01.wnl.0000188898.02018.95"},{"key":"ref=32","doi-asserted-by":"crossref","unstructured":"Hellwig K. Pregnancy in multiple sclerosis. Eur Neurol 2014; 72 (suppl 1): 39\u2009\u2013\u200942. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25278125&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1159\/000367640","DOI":"10.1159\/000367640"},{"key":"ref=33","doi-asserted-by":"crossref","unstructured":"Pakpoor J, Disanto G, Lacey MV et al. Breastfeeding and multiple sclerosis relapses: a meta-analysis. J\u00a0Neurol 2012; 259: 2246\u2009\u2013\u20098. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22619059&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1007\/s00415-012-6553-z","DOI":"10.1007\/s00415-012-6553-z"},{"key":"ref=34","doi-asserted-by":"crossref","unstructured":"Hellwig K, Rockhoff M, Herbstritt S et al. Exclusive Breastfeeding and the Effect on Postpartum Multiple Sclerosis Relapses. JAMA Neurol 2015; 72: 1132\u2009\u2013\u20098. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=26322399&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1001\/jamaneurol.2015.1806","DOI":"10.1001\/jamaneurol.2015.1806"},{"key":"ref=35","doi-asserted-by":"crossref","unstructured":"Hale TW, Siddiqui AA, Baker TE. Transfer of interferon \u03b2-1a into human breastmilk. Breastfeed Med 2012; 7: 123\u2009\u2013\u20095. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21988602&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1089\/bfm.2011.0044","DOI":"10.1089\/bfm.2011.0044"},{"key":"ref=36","doi-asserted-by":"crossref","unstructured":"Almas S, Vance J, Baker T et al. Management of Multiple Sclerosis in the Breastfeeding Mother. Mult Scler Int 2016; 2016: 6527458.","DOI":"10.1155\/2016\/6527458"},{"key":"ref=37","doi-asserted-by":"crossref","unstructured":"Baker TE, Cooper SD, Kessler L et al. Transfer of natalizumab into breast milk in a mother with multiple sclerosis. J Hum Lact 2015; 31: 233\u2009\u2013\u20096. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=25586712&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1177\/0890334414566237","DOI":"10.1177\/0890334414566237"}],"container-title":["Tidsskrift for Den norske legeforening"],"original-title":["Familieplanlegging, graviditet og amming ved multippel sklerose"],"language":"no","deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:02:32Z","timestamp":1781676152000},"score":1,"resource":{"primary":{"URL":"https:\/\/tidsskriftet.no\/2016\/11\/klinisk-oversikt\/familieplanlegging-graviditet-og-amming-ved-multippel-sklerose"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,8]]},"references-count":37,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2016,11,8]]}},"URL":"https:\/\/doi.org\/10.4045\/tidsskr.16.0563","relation":{},"ISSN":["0029-2001","0807-7096"],"issn-type":[{"value":"0029-2001","type":"print"},{"value":"0807-7096","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,8]]}}}