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Nasjonalt handlingsprogram med retningslinjer for diagnostikk, behandling og oppf\u00f8lging av maligne melanomer. IS-2931. 2020. https:\/\/www.helsedirektoratet.no\/retningslinjer\/maligne-melanomer-handlingsprogram\/Nasjonalt%20handlingsprogram%20med%20retningslinjer%20for%20diagnostikk,%20behandling%20og%20oppf%C3%B8lging%20av%20maligne%20melanomer.pdf\/ Lest 20.2.2022."},{"key":"ref=15","doi-asserted-by":"crossref","unstructured":"Trinidad CM, Torres-Cabala CA, Prieto VG et al. Update on eighth edition American Joint Committee on Cancer classification for Merkel cell carcinoma and histopathological parameters that determine prognosis. J Clin Pathol 2019; 72: 337\u201340.","DOI":"10.1136\/jclinpath-2018-205504"},{"key":"ref=16","unstructured":"Amin MB, Edge S, Greene F et al. AJCC cancer staging manual. 8. utg. Chicago IL: American Joint Committee on Cancer, Springer, 2017."},{"key":"ref=17","unstructured":"Perez\u00a0MC, de Pinho\u00a0FR, Holstein\u00a0A et al. 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