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PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21144989&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1016%2Fj.ccc.2010.11.006","DOI":"10.1016\/j.ccc.2010.11.006"},{"key":"ref=16","doi-asserted-by":"crossref","unstructured":"Barbosa\u00a0TM, Levy\u00a0SB. The impact of antibiotic use on resistance development and persistence. Drug Resist Updat 2000; 3: 303\u201311. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11498398&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1054%2Fdrup.2000.0167","DOI":"10.1054\/drup.2000.0167"},{"key":"ref=17","unstructured":"Helse- og omsorgsdepartementet. Handlingsplan mot antibiotikaresistens i helsetjenesten. https:\/\/www.regjeringen.no\/contentassets\/915655269bc04a47928fce917e4b25f5\/handlingsplan-antibiotikaresistens.pdf Lest 3.1.2024."},{"key":"ref=18","unstructured":"European Centre for Disease Prevention and Control. 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PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=31704215&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1016%2Fj.ijantimicag.2019.10.020","DOI":"10.1016\/j.ijantimicag.2019.10.020"},{"key":"ref=23","doi-asserted-by":"crossref","unstructured":"Gr\u00f8v\u00a0K, H\u00e5land\u00a0E, Waagsb\u00f8\u00a0B et al. Empirical antimicrobial therapy for bloodstream infections not compliant with guideline was associated with discordant therapy, which predicted poorer outcome even in a low resistance environment. Infect Dis (Lond) 2022; 54: 833\u201345. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35943909&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1080%2F23744235.2022.2109208","DOI":"10.1080\/23744235.2022.2109208"},{"key":"ref=24","doi-asserted-by":"crossref","unstructured":"Liljedahl Prytz\u00a0K, Prag\u00a0M, Fredlund\u00a0H et al. 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