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PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=35196406&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1111%2Fene.15299","DOI":"10.1111\/ene.15299"},{"key":"ref=25","doi-asserted-by":"crossref","unstructured":"Hale\u00a0GE, Hughes\u00a0CL, Burger\u00a0HG et al. Atypical estradiol secretion and ovulation patterns caused by luteal out-of-phase (LOOP) events underlying irregular ovulatory menstrual cycles in the menopausal transition. Menopause 2009; 16: 50\u20139. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18978637&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1097%2Fgme.0b013e31817ee0c2","DOI":"10.1097\/gme.0b013e31817ee0c2"},{"key":"ref=26","unstructured":"Metodebok i gynekologi og obstetrikk. 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PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=30508190&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1093%2Fhumupd%2Fdmy039","DOI":"10.1093\/humupd\/dmy039"},{"key":"ref=29","doi-asserted-by":"crossref","unstructured":"Hsu\u00a0S, Bove\u00a0R. Hormonal Therapies in Multiple Sclerosis: a Review of Clinical Data. Curr Neurol Neurosci Rep 2024; 24: 1\u201315. PubMed: http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38102502&dopt=Abstract, Crossref: http:\/\/dx.doi.org\/10.1007%2Fs11910-023-01326-7","DOI":"10.1007\/s11910-023-01326-7"},{"key":"ref=30","doi-asserted-by":"crossref","unstructured":"Voskuhl R. All women with multiple sclerosis should start hormone replacement therapy at menopause unless contraindicated: Yes. Multiple sclerosis (Houndmills, Basingstoke, England) 2024; 30: 1107\u20139.","DOI":"10.1177\/13524585241255002"},{"key":"ref=31","doi-asserted-by":"crossref","unstructured":"Magyari M. 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