{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T10:10:20Z","timestamp":1775038220367,"version":"3.50.1"},"reference-count":34,"publisher":"The Korean Academy of Tuberculosis and Respiratory Diseases","issue":"2","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Korean Academy of Tuberculosis and Respiratory Diseases"},{"name":"Asthma Study Group"}],"content-domain":{"domain":["e-trd.org"],"crossmark-restriction":true},"short-container-title":["Tuberc Respir Dis"],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:p>Background: Asthma remission has recently emerged as an aspirational treatment goal, yet its definition remains inconsistent across studies and expert groups. The absence of a standardized framework hampers its application in clinical practice and research, particularly in Korea where biologics use is rapidly increasing. This study aimed to establish a consensus definition of clinical remission in severe asthma among Korean experts.Methods: A two-round modified Delphi survey, followed by a focused third round, was conducted among 28 board-certified pulmonologists from the Korean Academy of Tuberculosis and Respiratory Diseases (KATRD). The questionnaire consisted of six domains and 27 items. Responses were analyzed using agreement rates, interquartile ranges, and content validity ratios to determine consensus levels.Results: Consensus was reached on defining clinical remission as a composite of no exacerbations, no systemic corticosteroid use, sustained symptom control (Asthma Control Test \u226520 on at least three occasions over 12 months), and stabilization and optimization of pulmonary function while on maintenance treatment. Experts agreed that pulmonary function should be assessed based on clinical judgment rather than absolute thresholds. Complete remission was additionally defined as fulfilling all clinical remission criteria with normalization of type 2 inflammation (blood eosinophils &lt;300\/\u03bcL and fractional exhaled nitric oxide &lt;25 ppb).Conclusion: This Delphi consensus provides a regionally relevant and pragmatic framework for defining remission in severe asthma. These statements may help guide clinical practice, inform guideline development, and support future research on remission as a treatment goal.<\/jats:p>","DOI":"10.4046\/trd.2025.0161","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T07:22:06Z","timestamp":1765264926000},"page":"215-225","update-policy":"https:\/\/doi.org\/10.4046\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Consensus of Korean Asthma Study Group on Definition of Clinical Remission in Severe Asthma: A Modified Delphi Study"],"prefix":"10.4046","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3164-889X","authenticated-orcid":true,"given":"Sun Hye","family":"Shin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6298-2204","authenticated-orcid":true,"given":"Joon Young","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junghee","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youlim","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Geol","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Yong","family":"Moon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin Kook","family":"Rhee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung Hoon","family":"Min","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Il","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0116-4683","authenticated-orcid":true,"given":"Yeon-Mok","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8098-3622","authenticated-orcid":true,"given":"Seong Yong","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the Korean Asthma Study Group in the Korean Academy of Tuberculosis and Respiratory Disease (KATRD)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2481","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.4046\/trd.2023.0052"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.04.009"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00804-2019"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-2600(23)00415-0"},{"key":"ref5","first-page":"757","volume-title":"An expert consensus framework asthma remission as a treatment goal","author":"Menzies-Gow","year":"2020"},{"key":"ref6","first-page":"3629","volume-title":"Severe asthma network Italy definition of clinical remission in severe asthma: a Delphi consensus","author":"Canonica","year":"2023"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2024.04.002"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2023.08.609"},{"key":"ref9","first-page":"461","volume-title":"Diagnosis and treatment of asthma: a guideline for respiratory specialists 2023: published by the German Respiratory Society (DGP) e. 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