{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:14:36Z","timestamp":1790709276314,"version":"4.1.0"},"reference-count":30,"publisher":"XMLink","issue":"4","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Key R&D Program of China","award":["2018YFC0910201"],"award-info":[{"award-number":["2018YFC0910201"]}]},{"name":"Science and Technology Planning Project of Guangzhou","award":["201704020176"],"award-info":[{"award-number":["201704020176"]}]},{"name":"Science and Technology Planning Project of Guangzhou","award":["201508020040"],"award-info":[{"award-number":["201508020040"]}]},{"name":"Science and Technology Planning Project of Guangzhou","award":["201510010044"],"award-info":[{"award-number":["201510010044"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2015ZZ125"],"award-info":[{"award-number":["2015ZZ125"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2014A020212274"],"award-info":[{"award-number":["2014A020212274"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["synapse.koreamed.org"],"crossmark-restriction":false},"short-container-title":["J Breast Cancer"],"published-print":{"date-parts":[[2018]]},"DOI":"10.4048\/jbc.2018.21.e56","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T08:32:00Z","timestamp":1544430720000},"page":"363","update-policy":"https:\/\/doi.org\/10.4048\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Identification and Validation of Circulating MicroRNA Signatures for Breast Cancer Early Detection Based on Large Scale Tissue-Derived Data"],"prefix":"10.4048","volume":"21","author":[{"given":"Xiaokang","family":"Yu","sequence":"first","affiliation":[{"name":"School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsheng","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Science, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingsong","family":"Li","sequence":"additional","affiliation":[{"name":"School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanli","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongdong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Science, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Science, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhen","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6419-0160","authenticated-orcid":false,"given":"Hongli","family":"Du","sequence":"additional","affiliation":[{"name":"School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18617","reference":[{"key":"10.4048\/jbc.2018.21.e56_ref1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3322\/caac.21262","volume":"65","author":"Torre","year":"2015","journal-title":"CA Cancer J Clin"},{"key":"10.4048\/jbc.2018.21.e56_ref2","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1200\/JOP.0768504","volume":"3","year":"2007","journal-title":"J Oncol Pract"},{"key":"10.4048\/jbc.2018.21.e56_ref3","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S1470-2045(15)00048-0","volume":"16","author":"Lin","year":"2015","journal-title":"Lancet Oncol"},{"key":"10.4048\/jbc.2018.21.e56_ref4","doi-asserted-by":"crossref","first-page":"10437","DOI":"10.1038\/srep10437","volume":"5","author":"Du","year":"2015","journal-title":"Sci Rep"},{"key":"10.4048\/jbc.2018.21.e56_ref5","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","volume":"105","author":"Mitchell","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.4048\/jbc.2018.21.e56_ref6","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/cr.2008.282","volume":"18","author":"Chen","year":"2008","journal-title":"Cell Res"},{"key":"10.4048\/jbc.2018.21.e56_ref7","doi-asserted-by":"crossref","first-page":"e3148","DOI":"10.1371\/journal.pone.0003148","volume":"3","author":"Gilad","year":"2008","journal-title":"PLoS One"},{"key":"10.4048\/jbc.2018.21.e56_ref8","doi-asserted-by":"crossref","first-page":"7248","DOI":"10.1093\/nar\/gkq601","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.4048\/jbc.2018.21.e56_ref9","doi-asserted-by":"crossref","first-page":"e13515","DOI":"10.1371\/journal.pone.0013515","volume":"5","author":"Pigati","year":"2010","journal-title":"PLoS One"},{"key":"10.4048\/jbc.2018.21.e56_ref10","doi-asserted-by":"crossref","first-page":"W553","DOI":"10.1093\/nar\/gks420","volume":"40","author":"Kayala","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"10.4048\/jbc.2018.21.e56_ref11","doi-asserted-by":"crossref","first-page":"5416","DOI":"10.18632\/oncotarget.6786","volume":"7","author":"Fr\u00e8res","year":"2016","journal-title":"Oncotarget"},{"key":"10.4048\/jbc.2018.21.e56_ref12","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1007\/s13277-014-3022-6","volume":"36","author":"Allaya","year":"2015","journal-title":"Tumour Biol"},{"key":"10.4048\/jbc.2018.21.e56_ref13","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12943-015-0301-9","volume":"14","author":"Chang","year":"2015","journal-title":"Mol Cancer"},{"key":"10.4048\/jbc.2018.21.e56_ref14","doi-asserted-by":"crossref","first-page":"24502","DOI":"10.1038\/srep24502","volume":"6","author":"Song","year":"2016","journal-title":"Sci Rep"},{"key":"10.4048\/jbc.2018.21.e56_ref15","doi-asserted-by":"crossref","first-page":"7733","DOI":"10.1007\/s13277-014-2025-7","volume":"35","author":"Calvano Filho","year":"2014","journal-title":"Tumour Biol"},{"key":"10.4048\/jbc.2018.21.e56_ref16","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1373\/clinchem.2015.238691","volume":"61","author":"Matamala","year":"2015","journal-title":"Clin Chem"},{"key":"10.4048\/jbc.2018.21.e56_ref17","doi-asserted-by":"crossref","first-page":"e96228","DOI":"10.1371\/journal.pone.0096228","volume":"9","author":"Ouyang","year":"2014","journal-title":"PLoS One"},{"key":"10.4048\/jbc.2018.21.e56_ref18","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1155\/2013\/259454","volume":"34","author":"Mar-Aguilar","year":"2013","journal-title":"Dis Markers"},{"issue":"3","key":"10.4048\/jbc.2018.21.e56_ref19","first-page":"gmr8338","volume":"15","author":"Li","year":"2016","journal-title":"Genet Mol Res"},{"key":"10.4048\/jbc.2018.21.e56_ref20","doi-asserted-by":"crossref","first-page":"6247","DOI":"10.2147\/OTT.S103650","volume":"9","author":"Pan","year":"2016","journal-title":"Onco Targets Ther"},{"key":"10.4048\/jbc.2018.21.e56_ref21","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/carcin\/bgw008","volume":"37","author":"Madhavan","year":"2016","journal-title":"Carcinogenesis"},{"key":"10.4048\/jbc.2018.21.e56_ref22","doi-asserted-by":"crossref","first-page":"11137","DOI":"10.1007\/s13277-014-2412-0","volume":"35","author":"Zhang","year":"2014","journal-title":"Tumour Biol"},{"key":"10.4048\/jbc.2018.21.e56_ref23","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3389\/fgene.2014.00149","volume":"5","author":"Zhu","year":"2014","journal-title":"Front Genet"},{"key":"10.4048\/jbc.2018.21.e56_ref24","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00432-012-1315-y","volume":"139","author":"Si","year":"2013","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.4048\/jbc.2018.21.e56_ref25","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.molonc.2014.03.002","volume":"8","author":"Kodahl","year":"2014","journal-title":"Mol Oncol"},{"key":"10.4048\/jbc.2018.21.e56_ref26","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/cas.12880","volume":"107","author":"Shimomura","year":"2016","journal-title":"Cancer Sci"},{"key":"10.4048\/jbc.2018.21.e56_ref27","first-page":"6929","volume":"14","author":"Dai","year":"2017","journal-title":"Oncol Lett"},{"key":"10.4048\/jbc.2018.21.e56_ref28","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.canlet.2014.08.020","volume":"354","author":"Doberstein","year":"2014","journal-title":"Cancer Lett"},{"key":"10.4048\/jbc.2018.21.e56_ref29","first-page":"1755","volume":"20","author":"Xia","year":"2016","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.4048\/jbc.2018.21.e56_ref30","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1111\/cas.13725","volume":"109","author":"Fan","year":"2018","journal-title":"Cancer Sci"}],"container-title":["Journal of Breast Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/synapse.koreamed.org\/pdf\/10.4048\/jbc.2018.21.e56","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/synapse.koreamed.org\/DOIx.php?id=10.4048\/jbc.2018.21.e56","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ejbc.kr\/DOIx.php?id=10.4048\/jbc.2018.21.e56","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T05:20:48Z","timestamp":1589520048000},"score":1,"resource":{"primary":{"URL":"https:\/\/ejbc.kr\/DOIx.php?id=10.4048\/jbc.2018.21.e56"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.4048\/jbc.2018.21.e56","relation":{},"ISSN":["1738-6756","2092-9900"],"issn-type":[{"value":"1738-6756","type":"print"},{"value":"2092-9900","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"https:\/\/synapse.koreamed.org\/DOIx.php?id=10.4048\/jbc.2018.21.e56","URL":"https:\/\/synapse.koreamed.org\/DOIx.php?id=10.4048\/jbc.2018.21.e56","name":"synapse","label":"Synapse","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"https:\/\/ejbc.kr\/DOIx.php?id=10.4048\/jbc.2018.21.e56","URL":"https:\/\/ejbc.kr\/DOIx.php?id=10.4048\/jbc.2018.21.e56","name":"the_journal","label":"the Journal","group":{"name":"multiple_resolution","label":"Full text available at:"}},{"value":"2018-08-06","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-09","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-10","name":"published_online","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"\u00a9 2018 Korean Breast Cancer Society","name":"copyright","label":"Copyright","group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","explanation":{"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},"group":{"name":"Copyright_and_licensing","label":"Copyright and Licensing"}}]}}