{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:04:27Z","timestamp":1790665467775,"version":"4.1.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":2350,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>CD160 promotes NK cell cytotoxicity and IFN-\u03b3 production, but the function of CD160 on CD8+ T cells remains unclear with some studies supporting a coinhibitory role and others a costimulatory role. In this study, we demonstrate that CD160 has a costimulatory role in promoting CD8+ T cell effector functions needed for optimal clearance of oral Listeria monocytogenes infection. CD160\u2212\/\u2212 mice did not clear oral L. monocytogenes as efficiently as wild type (WT) littermates. WT RAG\u2212\/\u2212 and CD160\u2212\/\u2212 RAG\u2212\/\u2212 mice similarly cleared L. monocytogenes, indicating that CD160 on NK cells does not contribute to impaired L. monocytogenes clearance. Defective L. monocytogenes clearance is due to compromised intraepithelial lymphocytes and CD8+ T cell functions. There was a reduction in the frequencies of granzyme B\u2013expressing intraepithelial lymphocytes in L. monocytogenes\u2013infected CD160\u2212\/\u2212 mice as compared with WT littermate controls. Similarly, the frequencies of granzyme B\u2013expressing splenic CD8+ T cells and IFN-\u03b3 and TNF-\u03b1 double-producer CD8+ T cells were significantly reduced in L. monocytogenes\u2013infected CD160\u2212\/\u2212 mice compared with WT littermates. Adoptive transfer studies showed that RAG\u2212\/\u2212 recipients receiving CD160\u2212\/\u2212 CD8+ T cells had a higher mortality, exhibited more weight loss, and had a higher bacterial burden compared with RAG\u2212\/\u2212 recipients receiving WT CD8+ T cells. These findings demonstrate that CD160 provides costimulatory signals to CD8+ T cells needed for optimal CD8+ T cell responses and protective immunity during an acute mucosal bacterial infection.<\/jats:p>","DOI":"10.4049\/immunohorizons.1800039","type":"journal-article","created":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T14:13:54Z","timestamp":1535379234000},"page":"238-250","source":"Crossref","is-referenced-by-count":34,"title":["CD160 Stimulates CD8+ T Cell Responses and Is Required for Optimal Protective Immunity to\n                    <i>Listeria monocytogenes<\/i>"],"prefix":"10.1093","volume":"2","author":[{"given":"Catherine L","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunobiology, Harvard Medical School , Boston, MA 02115"},{"name":"Evergrande Center for Immunologic Diseases, Harvard Medical School, Brigham and Women\u2019s Hospital , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Peluso","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunobiology, Harvard Medical School , Boston, MA 02115"},{"name":"Evergrande Center for Immunologic Diseases, Harvard Medical School, Brigham and Women\u2019s Hospital , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5675-5643","authenticated-orcid":false,"given":"Jefte M","family":"Drijvers","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunobiology, Harvard Medical School , Boston, MA 02115"},{"name":"Evergrande Center for Immunologic Diseases, Harvard Medical School, Brigham and Women\u2019s Hospital , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila M","family":"Mera","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunobiology, Harvard Medical School , Boston, MA 02115"},{"name":"Evergrande Center for Immunologic Diseases, Harvard Medical School, Brigham and Women\u2019s Hospital , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon M","family":"Grande","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunobiology, Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keturah E","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunobiology, Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3154-1403","authenticated-orcid":false,"given":"Jernej","family":"Godec","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunobiology, Harvard Medical School , Boston, MA 02115"},{"name":"Evergrande Center for Immunologic Diseases, Harvard Medical School, Brigham and Women\u2019s Hospital , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7210-5616","authenticated-orcid":false,"given":"Gordon J","family":"Freeman","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene H","family":"Sharpe","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunobiology, Harvard Medical School , Boston, MA 02115"},{"name":"Evergrande Center for Immunologic Diseases, Harvard Medical School, Brigham and Women\u2019s Hospital , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,8,27]]},"reference":[{"key":"2025010608380034000_r1","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1084\/jem.178.3.1121","article-title":"A novel 80-kD cell surface structure identifies human circulating lymphocytes with natural killer activity","volume":"178","author":"Ma\u00efza","year":"1993","journal-title":"J. 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