{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:27:15Z","timestamp":1774682835082,"version":"3.50.1"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":1985,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Infection with the intestinal parasite Giardia duodenalis is one of the most common causes of diarrheal disease in the world. Previous work has demonstrated that the cells and mechanisms of the adaptive immune system are critical for clearance of this parasite. However, the innate system has not been as well studied in the context of Giardia infection. We have previously demonstrated that Giardia infection leads to the accumulation of a population of CD11b+, F4\/80+, ARG1+, and NOS2+ macrophages in the small intestinal lamina propria. In this report, we sought to identify the accumulation mechanism of duodenal macrophages during Giardia infection and to determine if these cells were essential to the induction of protective Giardia immunity. We show that F4\/80+, CD11b+, CD11cint, CX3CR1+, MHC class II+, Ly6C\u2212, ARG1+, and NOS2+ macrophages accumulate in the small intestine during infections in mice. Consistent with this resident macrophage phenotype, macrophage accumulation does not require CCR2, and the macrophages incorporate EdU, indicating in situ proliferation rather than the recruitment of monocytes. Depletion of macrophages using anti-CSF1R did not impact parasite clearance nor development of regulatory T cell or Th17 cellular responses, suggesting that these macrophages are dispensable for protective Giardia immunity.<\/jats:p>","DOI":"10.4049\/immunohorizons.1900041","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T22:09:07Z","timestamp":1566943747000},"page":"412-421","source":"Crossref","is-referenced-by-count":14,"title":["Proliferation of Resident Macrophages Is Dispensable for Protection during <i>Giardia duodenalis<\/i> Infections"],"prefix":"10.1093","volume":"3","author":[{"given":"Marc Y","family":"Fink","sequence":"first","affiliation":[{"name":"Department of Biology, Georgetown University , Washington, DC 20057"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6405-883X","authenticated-orcid":false,"given":"Jenny","family":"Maloney","sequence":"additional","affiliation":[{"name":"Department of Biology, Georgetown University , Washington, DC 20057"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksander","family":"Keselman","sequence":"additional","affiliation":[{"name":"Department of Biology, Georgetown University , Washington, DC 20057"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erqiu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biology, Georgetown University , Washington, DC 20057"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Menegas","sequence":"additional","affiliation":[{"name":"Department of Biology, Georgetown University , Washington, DC 20057"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Staniorski","sequence":"additional","affiliation":[{"name":"Department of Biology, Georgetown University , Washington, DC 20057"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5719-7535","authenticated-orcid":false,"given":"Steven M","family":"Singer","sequence":"additional","affiliation":[{"name":"Department of Biology, Georgetown University , Washington, DC 20057"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,8,28]]},"reference":[{"key":"2025010608415278300_r1","doi-asserted-by":"crossref","first-page":"e1319","DOI":"10.1016\/S2214-109X(18)30351-6","article-title":"Use of quantitative molecular diagnostic methods to investigate the effect of enteropathogen infections on linear growth in children in low-resource settings: longitudinal analysis of results from the MAL-ED cohort study","volume":"6","author":"Rogawski","year":"2018","journal-title":"Lancet Glob. 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Immunol."},{"key":"2025010608415278300_r43","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.immuni.2008.05.019","article-title":"Gr1(+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii","volume":"29","author":"Dunay","year":"2008","journal-title":"Immunity"},{"key":"2025010608415278300_r44","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nm.3189","article-title":"Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection","volume":"19","author":"Grainger","year":"2013","journal-title":"Nat. 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Immunol. 15: 1090.]","volume":"15","author":"Bain","year":"2014","journal-title":"Nat. Immunol."},{"key":"2025010608415278300_r48","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/mi.2012.89","article-title":"Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors","volume":"6","author":"Bain","year":"2013","journal-title":"Mucosal Immunol."},{"key":"2025010608415278300_r49","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1002\/eji.201242847","article-title":"CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis","volume":"42","author":"Tamoutounour","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"2025010608415278300_r50","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.immuni.2012.08.026","article-title":"Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells","volume":"37","author":"Zigmond","year":"2012","journal-title":"Immunity"},{"key":"2025010608415278300_r51","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1084\/jem.20180019","article-title":"Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression","volume":"215","author":"Shaw","year":"2018","journal-title":"J. Exp. Med."},{"key":"2025010608415278300_r52","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1172\/JCI200519229","article-title":"Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity","volume":"115","author":"Smythies","year":"2005","journal-title":"J. Clin. 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Med. Microbiol."},{"key":"2025010608415278300_r58","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006120","article-title":"Characterization of the Giardia intestinalis secretome during interaction with human intestinal epithelial cells: the impact on host cells","volume":"11","author":"Ma\u2019ayeh","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"key":"2025010608415278300_r59","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1645\/GE-3021.1","article-title":"Giardia duodenalis assemblage-specific induction of apoptosis and tight junction disruption in human intestinal epithelial cells: effects of mixed infections","volume":"99","author":"Koh","year":"2013","journal-title":"J. Parasitol."},{"key":"2025010608415278300_r60","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation. [Published erratum appears in 2010 Nat. Rev. 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