{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T03:01:58Z","timestamp":1769914918112,"version":"3.49.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":1924,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Germinal centers (GCs) are essential for the production of somatically hypermutated, class-switched Abs that are protective against infection, but they also form in the absence of purposeful immunization or infection, and are termed spontaneous GCs (Spt-GCs). Although Spt-GCs can arise in nonautoimmune-prone mice, aberrant regulation of Spt-GCs in autoimmune-prone mice is strongly associated with the development of autoimmune diseases like systemic lupus erythematosus. The formation of Spt-GCs is crucially driven by TLR7-mediated RNA sensing. However, the impact of MAVS-dependent, Rig-like receptor\u2013mediated RNA sensing on the Spt-GC response remains unknown. In this study, we assessed the Spt-GC response and splenic B cell development in two MAVS-deficient mice with distinct genetic backgrounds. Importantly, we found that MAVS differentially controls Spt-GC responses and B cell development, depending on genetic background. B6\/129 mixed background MAVSKO mice had nearly absent Spt-GC responses in the spleen and cervical lymph nodes, which were associated with impaired splenic B cell development, in addition to impaired B cell activation and TLR7 expression. Interestingly, treatment of mice with TLR7 agonist could partially rescue GC responses by overcoming follicular B cell activation deficits. Contrastingly, the absence of MAVS on a B6 background resulted in normal B cell development and Spt-GC formation. Our results highlight important differences in the contribution of MAVS to B cell development and Spt-GC function, depending on the genetic background, warranting greater regard for the impact of genetic background in further studies using these mice for the study of autoimmunity.<\/jats:p>","DOI":"10.4049\/immunohorizons.1900048","type":"journal-article","created":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T18:25:13Z","timestamp":1570559113000},"page":"463-477","source":"Crossref","is-referenced-by-count":3,"title":["Strain-Dependent Contribution of MAVS to Spontaneous Germinal Center Responses"],"prefix":"10.1093","volume":"3","author":[{"given":"Stephanie L","family":"Schell","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Pennsylvania State University College of Medicine , Hershey, PA 17033"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sathi Babu","family":"Chodisetti","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Pennsylvania State University College of Medicine , Hershey, PA 17033"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam J","family":"Fike","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Pennsylvania State University College of Medicine , Hershey, PA 17033"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4801-4973","authenticated-orcid":false,"given":"Nicholas M","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Pennsylvania State University College of Medicine , Hershey, PA 17033"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8963-9780","authenticated-orcid":false,"given":"Kristen N","family":"Bricker","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Pennsylvania State University College of Medicine , Hershey, PA 17033"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8431-9681","authenticated-orcid":false,"given":"Ziaur S M","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Pennsylvania State University College of Medicine , Hershey, PA 17033"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,10,9]]},"reference":[{"key":"2025010608415980700_r1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1146\/annurev-immunol-020711-075032","article-title":"Germinal centers","volume":"30","author":"Victora","year":"2012","journal-title":"Annu. 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Immunol."},{"key":"2025010608415980700_r5","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/imcb.12003","article-title":"Crucial role of Mer tyrosine kinase in the maintenance of SIGN-R1+ marginal zone macrophages","volume":"96","author":"Soni","year":"2018","journal-title":"Immunol. Cell Biol."},{"key":"2025010608415980700_r6","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.4049\/jimmunol.1700611","article-title":"Mer receptor tyrosine kinase signaling prevents self-ligand sensing and aberrant selection in germinal centers","volume":"199","author":"Schell","year":"2017","journal-title":"J. Immunol."},{"key":"2025010608415980700_r7","doi-asserted-by":"crossref","first-page":"5667","DOI":"10.4049\/jimmunol.1201661","article-title":"The lupus-prone NZM2410\/NZW strain-derived Sle1b sublocus alters the germinal center checkpoint in female mice in a B cell-intrinsic manner","volume":"189","author":"Wong","year":"2012","journal-title":"J. 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