{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:40:58Z","timestamp":1793328058698,"version":"4.5.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":1832,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Tuft cells are an epithelial cell type critical for initiating type 2 immune responses to parasites and protozoa in the small intestine. To respond to these stimuli, intestinal tuft cells use taste chemosensory signaling pathways, but the role of taste receptors in type 2 immunity is poorly understood. In this study, we show that the taste receptor TAS1R3, which detects sweet and umami in the tongue, also regulates tuft cell responses in the distal small intestine. BALB\/c mice, which have an inactive form of TAS1R3, as well as Tas1r3-deficient C57BL6\/J mice both have severely impaired responses to tuft cell\u2013inducing signals in the ileum, including the protozoa Tritrichomonas muris and succinate. In contrast, TAS1R3 is not required to mount an immune response to the helminth Heligmosomoides polygyrus, which infects the proximal small intestine. Examination of uninfected Tas1r3\u2212\/\u2212 mice revealed a modest reduction in the number of tuft cells in the proximal small intestine but a severe decrease in the distal small intestine at homeostasis. Together, these results suggest that TAS1R3 influences intestinal immunity by shaping the epithelial cell landscape at steady-state.<\/jats:p>","DOI":"10.4049\/immunohorizons.1900099","type":"journal-article","created":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T20:15:12Z","timestamp":1579896912000},"page":"23-32","source":"Crossref","is-referenced-by-count":88,"title":["The Taste Receptor TAS1R3 Regulates Small Intestinal Tuft Cell Homeostasis"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3643-2468","authenticated-orcid":false,"given":"Michael R","family":"Howitt","sequence":"first","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health , Boston, MA 02115"},{"name":"Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health , Boston, MA 02115"},{"name":"Department of Pathology, Stanford University , Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7076-0270","authenticated-orcid":false,"given":"Y Grace","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health , Boston, MA 02115"},{"name":"Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2968-1159","authenticated-orcid":false,"given":"Matthew B","family":"Gologorsky","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University , Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7915-8908","authenticated-orcid":false,"given":"Jessica A","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, Stanford University , Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam L","family":"Haber","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard , Cambridge, MA 02142"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8330-1674","authenticated-orcid":false,"given":"Moshe","family":"Biton","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard , Cambridge, MA 02142"},{"name":"Department of Biological Regulation, Weizmann Institute of Science , Rehovot 7610001, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health , Boston, MA 02115"},{"name":"Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monia","family":"Michaud","sequence":"additional","affiliation":[{"name":"Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health , Boston, MA 02115"},{"name":"Department of Molecular Metabolism, Harvard T.H. 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Chan School of Public Health , Boston, MA 02115"},{"name":"Broad Institute of MIT and Harvard , Cambridge, MA 02142"},{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute , Boston, MA 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,1,25]]},"reference":[{"key":"2025010608420725000_r1","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1126\/science.aaf1648","article-title":"Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut","volume":"351","author":"Howitt","year":"2016","journal-title":"Science"},{"key":"2025010608420725000_r2","first-page":"221","article-title":"Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit","volume-title":"Nature","author":"von Moltke","year":"2016"},{"key":"2025010608420725000_r3","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature16527","article-title":"Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites","volume":"529","author":"Gerbe","year":"2016","journal-title":"Nature"},{"key":"2025010608420725000_r4","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0960-9822(98)70134-4","article-title":"A distinct role for interleukin-13 in Th2-cell-mediated immune responses","volume":"8","author":"McKenzie","year":"1998","journal-title":"Curr. 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