{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:10:46Z","timestamp":1791904246829,"version":"4.3.4"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":1711,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Rho family GTPases are critical for normal B cell development and function, and their activity is regulated by a large and complex network of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). However, the role of GAPs in B cell development is poorly understood. In this study, we show that the novel Rac-GAP ARHGAP25 is important for B cell development in mice in a CXCR4-dependent manner. We show that Arhgap25 deficiency in mice leads to a significant decrease in peripheral blood B cell numbers as well as defects in mature B cell differentiation. Arhgap25\u2212\/\u2212 B cells respond to Ag stimulation in vitro and in vivo but have impaired germinal center formation and decreased IgG1 class switching. Additionally, Arhgap25\u2212\/\u2212 B cells show evidence of increased baseline motility and augmented chemotaxis to CXCL12. Taken together, these studies demonstrate an important role for Arhgap25 in peripheral B cell development and Ag response.<\/jats:p>","DOI":"10.4049\/immunohorizons.2000021","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T20:31:44Z","timestamp":1590006704000},"page":"274-281","source":"Crossref","is-referenced-by-count":7,"title":["<i>Arhgap25<\/i>\n                    Deficiency Leads to Decreased Numbers of Peripheral Blood B Cells and Defective Germinal Center Reactions"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4956-3931","authenticated-orcid":false,"given":"Silke E","family":"Lindner","sequence":"first","affiliation":[{"name":"Department of Immuno-Oncology, Beckman Research Institute, City of Hope National Medical Center , Duarte, CA 91010"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8440-1271","authenticated-orcid":false,"given":"Colt A","family":"Egelston","sequence":"additional","affiliation":[{"name":"Department of Immuno-Oncology, Beckman Research Institute, City of Hope National Medical Center , Duarte, CA 91010"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2333-1852","authenticated-orcid":false,"given":"Stephanie M","family":"Huard","sequence":"additional","affiliation":[{"name":"Department of Immuno-Oncology, Beckman Research Institute, City of Hope National Medical Center , Duarte, CA 91010"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2660-4377","authenticated-orcid":false,"given":"Peter P","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Immuno-Oncology, Beckman Research Institute, City of Hope National Medical Center , Duarte, CA 91010"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2945-9005","authenticated-orcid":false,"given":"Leo D","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Immuno-Oncology, Beckman Research Institute, City of Hope National Medical Center , Duarte, CA 91010"},{"name":"Department of Pediatrics, City of Hope National Medical Center , Duarte, CA 91010"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,21]]},"reference":[{"key":"2025010608421842000_r1","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1084\/jem.173.5.1213","article-title":"Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow","volume":"173","author":"Hardy","year":"1991","journal-title":"J. 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