{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T13:18:08Z","timestamp":1771334288106,"version":"3.50.1"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":1680,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>CD8 T cells are considered important contributors to the immune response against Mycobacterium tuberculosis, yet limited information is currently known regarding their specific immune signature and phenotype. In this study, we applied a cell population transcriptomics strategy to define immune signatures of human latent tuberculosis infection (LTBI) in memory CD8 T cells. We found a 41-gene signature that discriminates between memory CD8 T cells from healthy LTBI subjects and uninfected controls. The gene signature was dominated by genes associated with mucosal-associated invariant T cells (MAITs) and reflected the lower frequency of MAITs observed in individuals with LTBI. There was no evidence for a conventional CD8 T cell\u2013specific signature between the two cohorts. We, therefore, investigated MAITs in more detail based on V\u03b17.2 and CD161 expression and staining with an MHC-related protein 1 (MR1) tetramer. This revealed two distinct populations of CD8+V\u03b17.2+CD161+ MAITs: MR1 tetramer+ and MR1 tetramer\u2212, which both had distinct gene expression compared with memory CD8 T cells. Transcriptomic analysis of LTBI versus noninfected individuals did not reveal significant differences for MR1 tetramer+ MAITs. However, gene expression of MR1 tetramer\u2212 MAITs showed large interindividual diversity and a tuberculosis-specific signature. This was further strengthened by a more diverse TCR-\u03b1 and -\u03b2 repertoire of MR1 tetramer\u2212 cells as compared with MR1 tetramer+. Thus, circulating memory CD8 T cells in subjects with latent tuberculosis have a reduced number of conventional MR1 tetramer+ MAITs as well as a difference in phenotype in the rare population of MR1 tetramer\u2212 MAITs compared with uninfected controls.<\/jats:p>","DOI":"10.4049\/immunohorizons.2000031","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T20:25:15Z","timestamp":1591302315000},"page":"292-307","source":"Crossref","is-referenced-by-count":25,"title":["Quantitative and Qualitative Perturbations of CD8+ MAITs in Healthy <i>Mycobacterium tuberculosis<\/i>\u2013Infected Individuals"],"prefix":"10.1093","volume":"4","author":[{"given":"Mikhail","family":"Pomaznoy","sequence":"first","affiliation":[{"name":"Division of Vaccine Discovery, La Jolla Institute for Immunology , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Kuan","sequence":"additional","affiliation":[{"name":"Division of Vaccine Discovery, La Jolla Institute for Immunology , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0042-1353","authenticated-orcid":false,"given":"Mikaela","family":"Lindvall","sequence":"additional","affiliation":[{"name":"Division of Vaccine Discovery, La Jolla Institute for Immunology , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1692-2758","authenticated-orcid":false,"given":"Julie G","family":"Burel","sequence":"additional","affiliation":[{"name":"Division of Vaccine Discovery, La Jolla Institute for Immunology , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8164-6852","authenticated-orcid":false,"given":"Gr\u00e9gory","family":"Seumois","sequence":"additional","affiliation":[{"name":"Division of Vaccine Discovery, La Jolla Institute for Immunology , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pandurangan","family":"Vijayanand","sequence":"additional","affiliation":[{"name":"Division of Vaccine Discovery, La Jolla Institute for Immunology , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0109-5991","authenticated-orcid":false,"given":"Randy","family":"Taplitz","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of California San Diego , La Jolla, CA 92093"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9037-0712","authenticated-orcid":false,"given":"Robert H","family":"Gilman","sequence":"additional","affiliation":[{"name":"Johns Hopkins University Bloomberg School of Public Health , Baltimore, MD 21205"},{"name":"Universidad Peruana Caytano Hereida , Lima 15102 ,","place":["Peru"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4622-7027","authenticated-orcid":false,"given":"Mayuko","family":"Saito","sequence":"additional","affiliation":[{"name":"Johns Hopkins University Bloomberg School of Public Health , Baltimore, MD 21205"},{"name":"Department of Virology, Tohuku University Graduate School of Medicine , Sendai 9808575 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M","family":"Lewinsohn","sequence":"additional","affiliation":[{"name":"Department of Medicine, VA Portland Health Care System , Portland, OR 97239"},{"name":"Pulmonary and Critical Care Medicine, Department of Medicine, Oregon Health & Science University , Portland, OR 97239"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Sette","sequence":"additional","affiliation":[{"name":"Division of Vaccine Discovery, La Jolla Institute for Immunology , La Jolla, CA 92037"},{"name":"Department of Medicine, University of California San Diego , La Jolla, CA 92093"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8457-6693","authenticated-orcid":false,"given":"Bjoern","family":"Peters","sequence":"additional","affiliation":[{"name":"Division of Vaccine Discovery, La Jolla Institute for Immunology , La Jolla, CA 92037"},{"name":"Department of Medicine, University of California San Diego , La Jolla, CA 92093"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7302-8002","authenticated-orcid":false,"given":"Cecilia S","family":"Lindestam Arlehamn","sequence":"additional","affiliation":[{"name":"Division of Vaccine Discovery, La Jolla Institute for Immunology , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,6,5]]},"reference":[{"key":"2025010608422217900_r1","volume-title":"Global Tuberculosis Report 2018","author":"World Health Organization","year":"2018"},{"key":"2025010608422217900_r2","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1126\/science.1184784","article-title":"Tuberculosis: what we don\u2019t know can, and does, hurt us","volume":"328","author":"Russell","year":"2010","journal-title":"Science"},{"key":"2025010608422217900_r3","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1056\/NEJM199106063242307","article-title":"Tuberculosis in patients with human immunodeficiency virus infection","volume":"324","author":"Barnes","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"2025010608422217900_r4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1146\/annurev.immunol.19.1.93","article-title":"Immunology of tuberculosis","volume":"19","author":"Flynn","year":"2001","journal-title":"Annu. Rev. Immunol."},{"key":"2025010608422217900_r5","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1172\/JCI123726","article-title":"Dengue-specific CD8+ T cell subsets display specialized transcriptomic and TCR profiles","volume":"130","author":"Tian","year":"2019","journal-title":"J. Clin. Invest."},{"key":"2025010608422217900_r6","doi-asserted-by":"crossref","first-page":"3283","DOI":"10.4049\/jimmunol.1800118","article-title":"Transcriptomic analysis of CD4+ T cells reveals novel immune signatures of latent tuberculosis","volume":"200","author":"Burel","year":"2018","journal-title":"J. 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