{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T03:45:10Z","timestamp":1770522310337,"version":"3.49.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":1619,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Respiratory virus infection normally drives neutrophil-dominated airway inflammation, yet some viral infections result in an eosinophil-dominated response in individuals such as allergic asthmatics. One idea is that viral infection simply exacerbates an ongoing type 2 response to allergen. However, prior exposure to allergen might alter the virus-induced innate response such that type 2\u2013like eosinophilic inflammation can be induced. To test this, mice were sensitized intranasally with house dust mite allergen and then at later times exposed to rhinovirus RV1B via the airways. RV1B infection of naive mice led to the expected neutrophilic lung inflammatory response with no eosinophils or mucus production. In contrast, if mice were exposed to RV1B 1\u20134 wk after house dust mite inhalation, when the allergen response had subsided, infection led to eosinophilia and mucus production and a much stronger lymphocyte response that were partially or fully steroid resistant. In accordance, RV1B infection resulted in elevated expression of several inflammatory factors in allergen\u2013pre-exposed mice, specifically those associated with type 2 immunity, namely CCL17, CXCL1, CCL2, IL-33, and IL-13. In vitro studies further showed that RV infection led to greater production of chemokines and cytokines in human bronchial epithelial cells that were previously stimulated with allergen, reinforcing the notion of an altered virus response after allergen exposure. In conclusion, we report that prior allergen exposure can modify responsiveness of cells in the lungs such that a qualitatively and quantitatively different inflammatory activity results following virus infection that is biased toward type 2\u2013like airway disease.<\/jats:p>","DOI":"10.4049\/immunohorizons.2000052","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T20:10:16Z","timestamp":1597349416000},"page":"498-507","source":"Crossref","is-referenced-by-count":10,"title":["Rhinovirus Infection Promotes Eosinophilic Airway Inflammation after Prior Exposure to House Dust Mite Allergen"],"prefix":"10.1093","volume":"4","author":[{"given":"Amit K","family":"Mehta","sequence":"first","affiliation":[{"name":"Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology , La Jolla, CA 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6062-3635","authenticated-orcid":false,"given":"Michael","family":"Croft","sequence":"additional","affiliation":[{"name":"Center for Autoimmunity and Inflammation, La Jolla Institute for Immunology , La Jolla, CA 92037"},{"name":"Department of Medicine, University of California , San Diego, La Jolla, CA 92093"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,8,14]]},"reference":[{"key":"2025010608423088000_r1","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1136\/bmj.307.6910.982","article-title":"Respiratory viruses and exacerbations of asthma in adults","volume":"307","author":"Nicholson","year":"1993","journal-title":"BMJ"},{"key":"2025010608423088000_r2","doi-asserted-by":"crossref","first-page":"S46","DOI":"10.1164\/ajrccm\/152.4_Pt_2.S46","article-title":"Natural and experimental rhinovirus infections of the lower respiratory tract","volume":"152","author":"Johnston","year":"1995","journal-title":"Am. 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