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Mice vaccinated with the HSV-1 0\u2206NLS were found to be more resistant to subsequent ocular virus challenge in terms of viral shedding, spread, the inflammatory response, and ocular pathology in a dose-dependent fashion. Specifically, a strong neutralizing Ab profile associated with low virus titers recovered from the cornea and trigeminal ganglia was observed in vaccinated mice in a dose-dependent fashion with doses ranging from 1 \u00d7 103 to 1 \u00d7 105 PFU HSV-1 0\u2206NLS. This correlation also existed in terms of viral latency in the trigeminal ganglia, corneal neovascularization, and leukocyte infiltration and expression of inflammatory cytokines and chemokines in infected tissue with the higher doses (1 \u00d7 104\u20131 \u00d7 105 PFU) of the HSV-1 0\u2206NLS\u2013vaccinated mice, displaying reduced viral latency, ocular pathology, or inflammation in comparison with the lowest dose (1 \u00d7 103 PFU) or vehicle vaccine employed. Fifteen HSV-1\u2013encoded proteins were uniquely recognized by antisera from high-dose (1 \u00d7 105 PFU)\u2013vaccinated mice in comparison with low-dose (1 \u00d7 103 PFU)\u2013 or vehicle-vaccinated animals. Passive immunization using high-dose\u2013vaccinated, but not low-dose\u2013vaccinated, mouse sera showed significant efficacy against ocular pathology in HSV-1\u2013challenged animals. In summary, we have identified the minimal protective dose of HSV-1 0\u2206NLS vaccine in mice to prevent HSV-mediated disease and identified candidate proteins that may be useful in the development of a noninfectious prophylactic vaccine against the insidious HSV-1 pathogen.<\/jats:p>","DOI":"10.4049\/immunohorizons.2000060","type":"journal-article","created":{"date-parts":[[2020,10,9]],"date-time":"2020-10-09T23:55:12Z","timestamp":1602287712000},"page":"608-626","source":"Crossref","is-referenced-by-count":10,"title":["Distinguishing Features of High- and Low-Dose Vaccine against Ocular HSV-1 Infection Correlates with Recognition of Specific HSV-1\u2013Encoded Proteins"],"prefix":"10.1093","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1954-2478","authenticated-orcid":false,"given":"Daniel J J","family":"Carr","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Oklahoma Health Sciences Center , Oklahoma City, OK 73104"},{"name":"Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center , Oklahoma City, OK 73104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grzegorz B","family":"Gmyrek","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Oklahoma Health Sciences Center , Oklahoma City, OK 73104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5134-0190","authenticated-orcid":false,"given":"Adrian","family":"Filiberti","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Oklahoma Health Sciences Center , Oklahoma City, OK 73104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda N","family":"Berube","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Oklahoma Health Sciences Center , Oklahoma City, OK 73104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William P","family":"Browne","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Oklahoma Health Sciences Center , Oklahoma City, OK 73104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brett M","family":"Gudgel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Oklahoma Health Sciences Center , Oklahoma City, OK 73104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7929-5950","authenticated-orcid":false,"given":"Virginie H","family":"Sjoelund","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular Biology and Cytometry Research, University of Oklahoma Health Sciences Center , Oklahoma City, OK 73104"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,10,12]]},"reference":[{"key":"2025010608424486800_r1","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1016\/j.jcrs.2006.08.027","article-title":"Noninvasive corneal stromal collagen imaging using two-photon-generated second-harmonic signals","volume":"32","author":"Morishige","year":"2006","journal-title":"J. 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