{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T22:26:12Z","timestamp":1759184772299,"version":"3.37.3"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":1408,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>NKT cells are primed lymphocytes that rapidly secrete cytokines and can directly kill cancerous cells. Given the critical role NKT cells play in cancer immune surveillance, we sought to investigate the effect of mutations in Brca1, specifically a conditional deletion of exon 11, on type I invariant NKT cell development. We observed a significant reduction in invariant NKT cells in both primary lymphoid and peripheral organs in Brca1 mutant mice compared with wild-type C57BL\/6. However, the original Brca1 mutant strain was on a mixed background containing FVB\/N. We determined that strain differences, rather than mutations in Brca1, led to the observed loss in NKT cells. Importantly, we found that whereas FVB\/N mice lack V\u03b28, there was a striking increase in the total number of thymic type I CD1d\u2013\u03b1-galactosylceramide tetramer positive NKT cells and skewing of the NKT cell population to NKT2 compared with C57BL\/6 mice. Collectively, our data demonstrate the profound effect genetics can have on NKT cell subset differentiation.<\/jats:p>","DOI":"10.4049\/immunohorizons.2000066","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T16:05:24Z","timestamp":1617206724000},"page":"147-156","source":"Crossref","is-referenced-by-count":2,"title":["Inbred Strain Characteristics Impact the NKT Cell Repertoire"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0660-9955","authenticated-orcid":false,"given":"Susannah C","family":"Shissler","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine , Baltimore, MD 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9781-9714","authenticated-orcid":false,"given":"Joshua P","family":"Bates","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine , Baltimore, MD 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danubia","family":"Hester","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine , Baltimore, MD 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laundette P","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine , Baltimore, MD 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3086-6414","authenticated-orcid":false,"given":"Tonya J","family":"Webb","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine , Baltimore, MD 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,3,1]]},"reference":[{"key":"2025010703474153500_r1","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1126\/science.7538697","article-title":"CD1 recognition by mouse NK1+ T lymphocytes","volume":"268","author":"Bendelac","year":"1995","journal-title":"Science"},{"key":"2025010703474153500_r2","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1126\/science.278.5343.1626","article-title":"CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides","volume":"278","author":"Kawano","year":"1997","journal-title":"Science"},{"key":"2025010703474153500_r3","doi-asserted-by":"crossref","first-page":"5248","DOI":"10.1073\/pnas.87.14.5248","article-title":"Homogenous junctional sequence of the V14+ T-cell antigen receptor alpha chain expanded in unprimed mice","volume":"87","author":"Koseki","year":"1990","journal-title":"Proc. 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