{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:40:51Z","timestamp":1774975251293,"version":"3.50.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":1558,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Peptic ulcers are caused by the interaction between bacterial and host factors. This study demonstrates enhanced expression of caspase-4 in peptic ulcer patient biopsies, indicating that pyroptosis and noncanonical inflammasome activity may be processes involved in peptic ulcer disease. We show that primary murine macrophages infected with Helicobacter pylori upregulate caspase-11 (the ortholog of human caspase-4), activate caspase-1, and secrete IL-1\u03b2. We demonstrate that misoprostol (a stable PGE1 analogue) decreased IL-1\u03b2 secretion and delayed lethality in vivo in a murine peritonitis model. PGE2 was shown to inhibit caspase-11\u2013driven pyroptosis and IL-1\u03b2 secretion in macrophages. Overall, we provide evidence for a pathological role of caspase-4\/11 in peptic ulcer disease and propose that targeting caspase-4 or inhibiting pyroptosis may have therapeutic potential in the management of peptic ulcers.<\/jats:p>","DOI":"10.4049\/immunohorizons.2000080","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T21:55:13Z","timestamp":1602539713000},"page":"627-633","source":"Crossref","is-referenced-by-count":10,"title":["Caspase-4: A Therapeutic Target for Peptic Ulcer Disease"],"prefix":"10.1093","volume":"4","author":[{"given":"Zbigniew","family":"Zaslona","sequence":"first","affiliation":[{"name":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin , Dublin 2 ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewelina","family":"Flis","sequence":"additional","affiliation":[{"name":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin , Dublin 2 ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1889-0171","authenticated-orcid":false,"given":"Ciara","family":"Nulty","sequence":"additional","affiliation":[{"name":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin , Dublin 2 ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0684-0436","authenticated-orcid":false,"given":"Jay","family":"Kearney","sequence":"additional","affiliation":[{"name":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin , Dublin 2 ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7056-0682","authenticated-orcid":false,"given":"Rebecca","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, School of Medicine, Trinity College Dublin , Dublin 2 ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atiyekeogbebe R","family":"Douglas","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, School of Medicine, Trinity College Dublin , Dublin 2 ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deirdre","family":"McNamara","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, School of Medicine, Trinity College Dublin , Dublin 2 ,","place":["Ireland"]},{"name":"Department of Gastroenterology, Tallaght University Hospital , Dublin D24 NR04 ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinead","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, School of Medicine, Trinity College Dublin , Dublin 2 ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke A J","family":"O\u2019Neill","sequence":"additional","affiliation":[{"name":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin , Dublin 2 ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7631-4370","authenticated-orcid":false,"given":"Emma M","family":"Creagh","sequence":"additional","affiliation":[{"name":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin , Dublin 2 ,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,10,13]]},"reference":[{"key":"2025010608423988400_r1","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1128\/IAI.73.4.1907-1916.2005","article-title":"Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells","volume":"73","author":"Fink","year":"2005","journal-title":"Infect. 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