{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:32:54Z","timestamp":1791495174672,"version":"4.3.4"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":1436,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Candida albicans is the most common, opportunistic human fungal pathogen whose complex interplay with the host innate immune system remains incompletely understood. In this study, we revealed that infection macrophages with C. albicans triggers prominent cell death, which is largely attributed to the RIPK3\/MLKL\u2013mediated necroptosis. Our results further demonstrated that the TSC1-mTOR pathway plays a pivotal role in the control of macrophage necroptosis upon engaging the Dectin-1\/2 and TLR-2\/4 pathways through fungal components \u03b2-glucan\/\u03b1-mannan or Sel1, respectively. Notably, the rapamycin-sensitive mTORC1 pathway, rather than the rapamycin-insensitive mTORC2 pathway, was responsible for elevated activation of RIPK1, RIPK3, and MLKL in TSC1-deficient macrophages. Following systemic infection with C. albicans, mice with macrophage\/neutrophil\u2013specific deletion of Tsc1 (Tsc1M\/N\u2212\/\u2212) showed heightened fungal burden in multiple organs, such as the kidney, liver, and spleen, severe morbidity, and mortality. Notably, Tsc1M\/N\u2212\/\u2212 kidneys exhibited prominent cell death and concomitant loss of tissue-resident macrophages, which likely contributing to a dampened phagocytosis of fungal pathogens. Together, our data demonstrate a crucial role for the TSC1-mTOR pathway in the regulation of macrophage necroptosis and suggest that both Dectin- and TLRs-induced necroptosis may undermine the immune defense effector functions of these innate receptors during C. albicans infection.<\/jats:p>","DOI":"10.4049\/immunohorizons.2000093","type":"journal-article","created":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T12:03:46Z","timestamp":1613563426000},"page":"90-101","source":"Crossref","is-referenced-by-count":12,"title":["TSC1 Suppresses Macrophage Necroptosis for the Control of Infection by Fungal Pathogen\n                    <i>Candida albicans<\/i>"],"prefix":"10.1093","volume":"5","author":[{"given":"Tiantian","family":"Li","sequence":"first","affiliation":[{"name":"Ear, Nose, and Throat Institute and Department of Otorhinolaryngology, Eye and Ear, Nose, and Throat Hospital, Fudan University , 200031 Shanghai ,","place":["China"]},{"name":"The Center for Microbes, Development and Health, Chinese Academy of Sciences, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 200031 Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadong","family":"Xie","sequence":"additional","affiliation":[{"name":"Ear, Nose, and Throat Institute and Department of Otorhinolaryngology, Eye and Ear, Nose, and Throat Hospital, Fudan University , 200031 Shanghai ,","place":["China"]},{"name":"The Center for Microbes, Development and Health, Chinese Academy of Sciences, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 200031 Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shi","sequence":"additional","affiliation":[{"name":"The Center for Microbes, Development and Health, Chinese Academy of Sciences, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 200031 Shanghai ,","place":["China"]},{"name":"School of Life Sciences, Lanzhou University , Lanzhou, Gansu 730000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumeng","family":"Sun","sequence":"additional","affiliation":[{"name":"The Center for Microbes, Development and Health, Chinese Academy of Sciences, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 200031 Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wen","sequence":"additional","affiliation":[{"name":"The Center for Microbes, Development and Health, Chinese Academy of Sciences, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 200031 Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihou","family":"Deng","sequence":"additional","affiliation":[{"name":"The Center for Microbes, Development and Health, Chinese Academy of Sciences, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 200031 Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 200031 Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huabin","family":"Li","sequence":"additional","affiliation":[{"name":"Ear, Nose, and Throat Institute and Department of Otorhinolaryngology, Eye and Ear, Nose, and Throat Hospital, Fudan University , 200031 Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbo","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Lanzhou University , Lanzhou, Gansu 730000 ,","place":["China"]},{"name":"Marine Drug Screening and Evaluation Platform, Qingdao National Laboratory for Marine Science and Technology, Ocean University of China , Qingdao, 266071 Shandong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5304-243X","authenticated-orcid":false,"given":"Hui","family":"Xiao","sequence":"additional","affiliation":[{"name":"The Center for Microbes, Development and Health, Chinese Academy of Sciences, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences , 200031 Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"key":"2025010703474034800_r1","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1056\/NEJMra1315399","article-title":"Invasive candidiasis","volume":"373","author":"Kullberg","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"2025010703474034800_r2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev-immunol-042617-053318","article-title":"Host control of fungal infections: lessons from basic studies and human cohorts","volume":"36","author":"Lionakis","year":"2018","journal-title":"Annu. Rev. Immunol."},{"key":"2025010703474034800_r3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nrmicro1815","article-title":"An integrated model of the recognition of Candida albicans by the innate immune system","volume":"6","author":"Netea","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"2025010703474034800_r4","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/s41467-019-08950-3","article-title":"A small secreted protein triggers a TLR2\/4-dependent inflammatory response during invasive Candida albicans infection","volume":"10","author":"Wang","year":"2019","journal-title":"Nat. Commun."},{"key":"2025010703474034800_r5","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/ni.3155","article-title":"Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses","volume":"16","author":"Deng","year":"2015","journal-title":"Nat. Immunol."},{"key":"2025010703474034800_r6","doi-asserted-by":"crossref","first-page":"44143","DOI":"10.1074\/jbc.M112.414276","article-title":"Tumor necrosis factor receptor-associated factor 6 (TRAF6) and TGF\u03b2-activated kinase 1 (TAK1) play essential roles in the C-type lectin receptor signaling in response to Candida albicans infection","volume":"287","author":"Gorjestani","year":"2012","journal-title":"J. Biol. Chem."},{"key":"2025010703474034800_r7","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1084\/jem.20151932","article-title":"E3 ubiquitin ligase Cbl-b negatively regulates C-type lectin receptor-mediated antifungal innate immunity","volume":"213","author":"Zhu","year":"2016","journal-title":"J. Exp. Med."},{"key":"2025010703474034800_r8","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/nm.4134","article-title":"Inhibition of CBLB protects from lethal Candida albicans sepsis","volume":"22","author":"Wirnsberger","year":"2016","journal-title":"Nat. Med."},{"key":"2025010703474034800_r9","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/nm.4141","article-title":"Targeting CBLB as a potential therapeutic approach for disseminated candidiasis","volume":"22","author":"Xiao","year":"2016","journal-title":"Nat. Med."},{"key":"2025010703474034800_r10","first-page":"5000","article-title":"Elimination of mouse splenic macrophages correlates with increased susceptibility to experimental disseminated candidiasis","volume-title":"J. Immunol.","author":"Qian","year":"1994"},{"key":"2025010703474034800_r11","doi-asserted-by":"crossref","first-page":"5035","DOI":"10.1172\/JCI71307","article-title":"CX3CR1-dependent renal macrophage survival promotes Candida control and host survival","volume":"123","author":"Lionakis","year":"2013","journal-title":"J. Clin. Invest."},{"key":"2025010703474034800_r12","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1128\/EC.00336-13","article-title":"Candida albicans triggers NLRP3-mediated pyroptosis in macrophages","volume":"13","author":"Wellington","year":"2014","journal-title":"Eukaryot. Cell"},{"key":"2025010703474034800_r13","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00003-14","article-title":"The pathogen Candida albicans hijacks pyroptosis for escape from macrophages","volume":"5","author":"Uwamahoro","year":"2014","journal-title":"mBio"},{"key":"2025010703474034800_r14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev-pathol-052016-100247","article-title":"Necroptosis: mechanisms and relevance to disease","volume":"12","author":"Galluzzi","year":"2017","journal-title":"Annu. Rev. Pathol."},{"key":"2025010703474034800_r15","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.celrep.2014.04.026","article-title":"MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates","volume":"7","author":"Dondelinger","year":"2014","journal-title":"Cell Rep."},{"key":"2025010703474034800_r16","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/ncb2883","article-title":"Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis. [Published erratum appears in 2014 Nat. Cell Biol. 16: 200.]","volume":"16","author":"Cai","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"2025010703474034800_r17","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.molcel.2014.03.003","article-title":"Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3","volume":"54","author":"Wang","year":"2014","journal-title":"Mol. Cell"},{"key":"2025010703474034800_r18","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/cr.2013.171","article-title":"Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death","volume":"24","author":"Chen","year":"2014","journal-title":"Cell Res."},{"key":"2025010703474034800_r19","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nature14191","article-title":"Necroptosis and its role in inflammation","volume":"517","author":"Pasparakis","year":"2015","journal-title":"Nature"},{"key":"2025010703474034800_r20","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.molcel.2017.02.024","article-title":"An inflammatory perspective on necroptosis","volume":"65","author":"Kearney","year":"2017","journal-title":"Mol. Cell"},{"key":"2025010703474034800_r21","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1038\/s41418-019-0323-8","article-title":"Dectin-1-induced RIPK1 and RIPK3 activation protects host against Candida albicans infection","volume":"26","author":"Cao","year":"2019","journal-title":"Cell Death Differ."},{"key":"2025010703474034800_r22","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.chom.2016.09.014","article-title":"DAI senses influenza A virus genomic RNA and activates RIPK3-dependent cell death","volume":"20","author":"Thapa","year":"2016","journal-title":"Cell Host Microbe"},{"key":"2025010703474034800_r23","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.chom.2012.01.016","article-title":"DAI\/ZBP1\/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA","volume":"11","author":"Upton","year":"2012","journal-title":"Cell Host Microbe"},{"key":"2025010703474034800_r24","doi-asserted-by":"crossref","first-page":"11506","DOI":"10.1073\/pnas.1700999114","article-title":"Inhibition of DAI-dependent necroptosis by the Z-DNA binding domain of the vaccinia virus innate immune evasion protein, E3","volume":"114","author":"Koehler","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025010703474034800_r25","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.immuni.2014.12.020","article-title":"Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection","volume":"42","author":"Bl\u00e9riot","year":"2015","journal-title":"Immunity"},{"key":"2025010703474034800_r26","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1016\/j.celrep.2016.07.039","article-title":"Necroptosis promotes Staphylococcus aureus clearance by inhibiting excessive inflammatory signaling","volume":"16","author":"Kitur","year":"2016","journal-title":"Cell Rep."},{"key":"2025010703474034800_r27","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1038\/s41467-017-02035-9","article-title":"Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death","volume":"8","author":"Hartmann","year":"2017","journal-title":"Nat. Commun."},{"key":"2025010703474034800_r28","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.chom.2015.01.002","article-title":"RIP1\/RIP3 binding to HSV-1 ICP6 initiates necroptosis to restrict virus propagation in mice","volume":"17","author":"Huang","year":"2015","journal-title":"Cell Host Microbe"},{"key":"2025010703474034800_r29","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.chom.2010.03.006","article-title":"Virus inhibition of RIP3-dependent necrosis","volume":"7","author":"Upton","year":"2010","journal-title":"Cell Host Microbe"},{"key":"2025010703474034800_r30","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41556-018-0205-1","article-title":"mTOR as a central hub of nutrient signalling and cell growth","volume":"21","author":"Kim","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"2025010703474034800_r31","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","article-title":"mTOR signaling in growth, metabolism, and disease. [Published erratum appears in 2017 Cell 169: 361\u2013371.]","volume":"168","author":"Saxton","year":"2017","journal-title":"Cell"},{"key":"2025010703474034800_r32","first-page":"3658","article-title":"The role of tuberous sclerosis complex 1 in regulating innate immunity","volume-title":"J. Immunol.","author":"Pan","year":"2012"},{"key":"2025010703474034800_r33","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/cmi.2015.43","article-title":"TSC1 controls IL-1\u03b2 expression in macrophages via mTORC1-dependent C\/EBP\u03b2 pathway","volume":"13","author":"Yang","year":"2016","journal-title":"Cell. Mol. Immunol."},{"key":"2025010703474034800_r34","doi-asserted-by":"crossref","first-page":"4696","DOI":"10.1038\/ncomms5696","article-title":"TSC1 controls macrophage polarization to prevent inflammatory disease","volume":"5","author":"Zhu","year":"2014","journal-title":"Nat. Commun."},{"key":"2025010703474034800_r35","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1038\/ncomms3834","article-title":"The TSC-mTOR pathway regulates macrophage polarization","volume":"4","author":"Byles","year":"2013","journal-title":"Nat. Commun."},{"key":"2025010703474034800_r36","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1159\/000430306","article-title":"Tsc1 is a critical regulator of macrophage survival and function","volume":"36","author":"Fang","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"2025010703474034800_r37","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.bbrc.2018.03.027","article-title":"Tsc1 controls the development and function of alveolar macrophages","volume":"498","author":"Chen","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2025010703474034800_r38","article-title":"mTOR- and HIF-1\u03b1-mediated aerobic glycolysis as metabolic basis for trained immunity. [Published erratum appears in 2014 Science 346: aaa1503.]","volume":"345","author":"Cheng","year":"2014","journal-title":"Science"},{"key":"2025010703474034800_r39","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cell.2017.11.025","article-title":"Metabolic induction of trained immunity through the mevalonate pathway","volume":"172","author":"Bekkering","year":"2018","journal-title":"Cell"},{"key":"2025010703474034800_r40","doi-asserted-by":"crossref","DOI":"10.1126\/science.1251086","article-title":"Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity","volume":"345","author":"Saeed","year":"2014","journal-title":"Science"},{"key":"2025010703474034800_r41","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1172\/JCI133264","article-title":"Gut epithelial TSC1\/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer","volume":"130","author":"Xie","year":"2020","journal-title":"J. Clin. Invest."},{"key":"2025010703474034800_r42","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/hmg\/11.5.525","article-title":"A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells","volume":"11","author":"Kwiatkowski","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"2025010703474034800_r43","doi-asserted-by":"crossref","first-page":"9508","DOI":"10.1128\/MCB.24.21.9508-9516.2004","article-title":"Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development","volume":"24","author":"Gangloff","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"2025010703474034800_r44","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/nature09584","article-title":"mTORC1 controls fasting-induced ketogenesis and its modulation by ageing","volume":"468","author":"Sengupta","year":"2010","journal-title":"Nature"},{"key":"2025010703474034800_r45","first-page":"1850","article-title":"A critical role for Rictor in T lymphopoiesis","volume-title":"J. Immunol.","author":"Tang","year":"2012"},{"key":"2025010703474034800_r46","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1023\/A:1008942828960","article-title":"Conditional gene targeting in macrophages and granulocytes using LysMcre mice","volume":"8","author":"Clausen","year":"1999","journal-title":"Transgenic Res."},{"key":"2025010703474034800_r47","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.celrep.2017.04.011","article-title":"RIPK3 mediates necroptosis during embryonic development and postnatal inflammation in fadd-deficient mice","volume":"19","author":"Zhao","year":"2017","journal-title":"Cell Rep."},{"key":"2025010703474034800_r48","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1016\/j.celrep.2016.06.103","article-title":"MLKL and FADD are critical for suppressing progressive lymphoproliferative disease and activating the NLRP3 inflammasome","volume":"16","author":"Zhang","year":"2016","journal-title":"Cell Rep."},{"key":"2025010703474034800_r49","doi-asserted-by":"crossref","first-page":"E5944","DOI":"10.1073\/pnas.1806973115","article-title":"Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNF\u03b1-mediated apoptosis","volume":"115","author":"Amin","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025010703474034800_r50","first-page":"237","article-title":"Host genetic signatures of susceptibility to fungal disease","volume":"422","author":"Campos","year":"2019","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"2025010703474034800_r51","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.1002\/eji.201141411","article-title":"Regulation of T-cell survival and mitochondrial homeostasis by TSC1","volume":"41","author":"O\u2019Brien","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"2025010703474034800_r52","article-title":"TSC1\/2 signaling complex is essential for peripheral na\u00efve CD8+ T cell survival and homeostasis in mice","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"key":"2025010703474034800_r53","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/ni.2068","article-title":"The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function","volume":"12","author":"Yang","year":"2011","journal-title":"Nat. Immunol."},{"key":"2025010703474034800_r54","doi-asserted-by":"crossref","first-page":"E4894","DOI":"10.1073\/pnas.1308905110","article-title":"Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells","volume":"110","author":"Wang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025010703474034800_r55","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/nri3897","article-title":"Immune defence against Candida fungal infections","volume":"15","author":"Netea","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"2025010703474034800_r56","doi-asserted-by":"crossref","first-page":"E9618","DOI":"10.1073\/pnas.1708247114","article-title":"Necroptosis controls NET generation and mediates complement activation, endothelial damage, and autoimmune vasculitis","volume":"114","author":"Schreiber","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025010703474034800_r57","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aao1716","article-title":"The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils","volume":"11","author":"D\u2019Cruz","year":"2018","journal-title":"Sci. Signal."},{"key":"2025010703474034800_r58","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nrm3683","article-title":"Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death","volume":"14","author":"Ofengeim","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2025010703474034800_r59","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.molcel.2017.05.003","article-title":"MK2 phosphorylates RIPK1 to prevent TNF-induced cell death","volume":"66","author":"Jaco","year":"2017","journal-title":"Mol. Cell"},{"key":"2025010703474034800_r60","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1038\/ncb3608","article-title":"MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death","volume":"19","author":"Dondelinger","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"2025010703474034800_r61","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/ncb3614","article-title":"p38MAPK\/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection","volume":"19","author":"Menon","year":"2017","journal-title":"Nat. Cell Biol."},{"key":"2025010703474034800_r62","doi-asserted-by":"crossref","first-page":"11944","DOI":"10.1073\/pnas.1715742114","article-title":"PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP","volume":"114","author":"Wang","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025010703474034800_r63","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.cell.2018.07.041","article-title":"TBK1 suppresses RIPK1-driven apoptosis and inflammation during development and in aging","volume":"174","author":"Xu","year":"2018","journal-title":"Cell"}],"container-title":["ImmunoHorizons"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/immunohorizons\/article-pdf\/5\/2\/90\/60187650\/ih2000093.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/immunohorizons\/article-pdf\/5\/2\/90\/60187650\/ih2000093.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T22:49:51Z","timestamp":1736203791000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/immunohorizons\/article\/5\/2\/90\/7820227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,1]]},"references-count":63,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2,1]]}},"URL":"https:\/\/doi.org\/10.4049\/immunohorizons.2000093","relation":{},"ISSN":["2573-7732"],"issn-type":[{"value":"2573-7732","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,2]]},"published":{"date-parts":[[2021,2,1]]}}}