{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T01:46:27Z","timestamp":1773971187099,"version":"3.50.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":1102,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>NK cells are important mediators of viral control with the capacity to form adaptive immune features following infection. However, studies of infection-induced adaptive NK cells require adoptive cell transfer to lower the precursor frequency of \u201cAg-specific\u201d NK cells, potentially limiting the diversity of the NK cell response. In seeking an unmanipulated model to probe the adaptive NK cells, we interrogated a wide range of Collaborative Cross (CC) inbred mice, inbred mouse strains that exhibit broad genetic diversity across strains. Our assessment identified and validated a putative \u201cideal\u201d CC strain, CC006, which does not require manipulation to generate and maintain adaptive NK cells. Critically, CC006 mice, in contrast to C57BL\/6 mice, are capable of developing enhanced NK cell\u2013mediated protective responses to murine CMV infection following m157-mediated vaccination. This work both furthers our understanding of adaptive NK cells and demonstrates the utility of CC mice in the development and interrogation of immunologic models.<\/jats:p>","DOI":"10.4049\/immunohorizons.2100113","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T15:40:13Z","timestamp":1642174813000},"page":"8-15","source":"Crossref","is-referenced-by-count":8,"title":["Novel Mouse Model of Murine Cytomegalovirus\u2013Induced Adaptive NK Cells"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3107-3961","authenticated-orcid":false,"given":"Isaac J","family":"Jensen","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Columbia University Irving Medical Center , New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew D","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Urology, University of Minnesota , Minneapolis, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep K","family":"Tripathy","sequence":"additional","affiliation":[{"name":"Department of Medicine, Gastroenterology Division, Washington University School of Medicine , St. Louis, MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3180-2439","authenticated-orcid":false,"given":"Vladimir P","family":"Badovinac","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Iowa , Iowa City, IA"},{"name":"Interdisciplinary Graduate Program in Immunology, University of Iowa , Iowa City, IA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,1,1]]},"reference":[{"key":"2025010703504657600_r1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.smim.2014.02.007","article-title":"NK cell self tolerance, responsiveness and missing self recognition","volume":"26","author":"Shifrin","year":"2014","journal-title":"Semin. 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