{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:00:45Z","timestamp":1790413245464,"version":"4.1.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":1071,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>STAT4 plays a critical role in the generation of both innate and adaptive immune responses. In the absence of STAT4, Th1 responses, critical for resistance to fungal disease, do not occur. Infection with the dimorphic fungus, Coccidioides, is a major cause of community-acquired pneumonia in the endemic regions of Arizona and California. In some people and often for unknown reasons, coccidioidal infection results in hematogenous dissemination and progressive disease rather than the typical self-limited pneumonia. Members of three generations in a family developed disseminated coccidioidomycosis, prompting genetic investigation. All affected family members had a single heterozygous base change in STAT4, c.1877A&amp;gt;G, causing substitution of glycine for glutamate at AA626 (STAT4E626G\/+). A knockin mouse, heterozygous for the substitution, developed more severe experimental coccidioidomycosis than did wild-type mice. Stat4E626G\/+ T cells were deficient in production of IFN-\u03b3 after anti-CD3\/CD28 stimulation. Spleen cells from Stat4E626G mice showed defective responses to IL-12\/IL-18 stimulation in vitro. In vivo, early postinfection, mutant Stat4E626G\/+ mice failed to produce IFN-\u03b3 and related cytokines in the lung and to accumulate activated adaptive immune cells in mediastinal lymph nodes. Therefore, defective early induction of IFN-\u03b3 and adaptive responses by STAT4 prevents normal control of coccidioidomycosis in both mice and humans.<\/jats:p>","DOI":"10.4049\/immunohorizons.2200007","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T15:40:22Z","timestamp":1644594022000},"page":"130-143","source":"Crossref","is-referenced-by-count":13,"title":["Mouse Model of a Human STAT4 Point Mutation That Predisposes to Disseminated Coccidiomycosis"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0503-3330","authenticated-orcid":false,"given":"Daniel A","family":"Powell","sequence":"first","affiliation":[{"name":"Valley Fever Center for Excellence, University of Arizona , Tucson, AZ"},{"name":"Department of Immunobiology, University of Arizona , Tucson, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy P","family":"Hsu","sequence":"additional","affiliation":[{"name":"National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa F","family":"Shubitz","sequence":"additional","affiliation":[{"name":"Valley Fever Center for Excellence, University of Arizona , Tucson, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine D","family":"Butkiewicz","sequence":"additional","affiliation":[{"name":"Valley Fever Center for Excellence, University of Arizona , Tucson, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary","family":"Moale","sequence":"additional","affiliation":[{"name":"Valley Fever Center for Excellence, University of Arizona , Tucson, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7744-799X","authenticated-orcid":false,"given":"Hien T","family":"Trinh","sequence":"additional","affiliation":[{"name":"Valley Fever Center for Excellence, University of Arizona , Tucson, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Doetschman","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, University of Arizona , Tucson, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8632-8714","authenticated-orcid":false,"given":"Teodora G","family":"Georgieva","sequence":"additional","affiliation":[{"name":"Department of Cellular and Molecular Medicine, University of Arizona , Tucson, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dakota M","family":"Reinartz","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, University of Arizona , Tucson, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2803-3280","authenticated-orcid":false,"given":"Justin E","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, University of Arizona , Tucson, AZ"},{"name":"The University of Arizona Cancer Center, University of Arizona , Tucson, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc J","family":"Orbach","sequence":"additional","affiliation":[{"name":"Valley Fever Center for Excellence, University of Arizona , Tucson, AZ"},{"name":"Department of Plant Sciences, University of Arizona , Tucson, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3207-5464","authenticated-orcid":false,"given":"Steven M","family":"Holland","sequence":"additional","affiliation":[{"name":"National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John N","family":"Galgiani","sequence":"additional","affiliation":[{"name":"Valley Fever Center for Excellence, University of Arizona , Tucson, AZ"},{"name":"Department of Medicine, University of Arizona , Tucson, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2503-6267","authenticated-orcid":false,"given":"Jeffrey A","family":"Frelinger","sequence":"additional","affiliation":[{"name":"Valley Fever Center for Excellence, University of Arizona , Tucson, AZ"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,1]]},"reference":[{"key":"2025010703510641900_r1","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.4049\/jimmunol.173.6.4075","article-title":"STAT4 is a critical mediator of early innate immune responses against pulmonary Klebsiella infection","volume":"173","author":"Deng","year":"2004","journal-title":"J. Immunol."},{"key":"2025010703510641900_r2","doi-asserted-by":"crossref","first-page":"e91894","DOI":"10.1172\/jci.insight.91894","article-title":"Murine models of Pneumocystis infection recapitulate human primary immune disorders","volume":"3","author":"Elsegeiny","year":"2018","journal-title":"JCI Insight"},{"key":"2025010703510641900_r3","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1126\/science.1059835","article-title":"Role of T-bet in commitment of TH1 cells before IL-12-dependent selection","volume":"292","author":"Mullen","year":"2001","journal-title":"Science"},{"key":"2025010703510641900_r4","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1093\/infdis\/jix522","article-title":"Paracoccidioidomycosis associated with a heterozygous STAT4 mutation and impaired IFN-\u03b3 immunity","volume":"216","author":"Schimke","year":"2017","journal-title":"J. Infect. Dis."},{"key":"2025010703510641900_r5","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.immuni.2008.08.017","article-title":"Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination","volume":"29","author":"Thieu","year":"2008","journal-title":"Immunity"},{"key":"2025010703510641900_r6","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1084\/jem.20170457","article-title":"STAT4 and T-bet control follicular helper T cell development in viral infections. [Published erratum appears in 2018 J. Exp. Med. 215: 999.]","volume":"215","author":"Weinstein","year":"2018","journal-title":"J. Exp. Med."},{"key":"2025010703510641900_r7","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.immuni.2012.09.007","article-title":"The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses","volume":"37","author":"Zhu","year":"2012","journal-title":"Immunity"},{"issue":"D1","key":"2025010703510641900_r8","doi-asserted-by":"crossref","first-page":"D723","DOI":"10.1093\/nar\/gkw1040","article-title":"Mouse Genome Database (MGD)-2017: community knowledge resource for the laboratory mouse","volume":"45","author":"Blake","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"2025010703510641900_r9","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1073\/pnas.94.2.599","article-title":"Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand","volume":"94","author":"Balashov","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025010703510641900_r10","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1086\/375587","article-title":"Clinical tuberculosis in 2 of 3 siblings with interleukin-12 receptor beta1 deficiency","volume":"37","author":"Caragol","year":"2003","journal-title":"Clin. Infect. Dis."},{"key":"2025010703510641900_r11","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1172\/JCI3125","article-title":"Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy","volume":"102","author":"Comabella","year":"1998","journal-title":"J. Clin. Invest."},{"key":"2025010703510641900_r12","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/S0161-6420(98)99035-2","article-title":"High levels of interleukin-12 in the aqueous humor and vitreous of patients with uveitis","volume":"105","author":"El-Shabrawi","year":"1998","journal-title":"Ophthalmology"},{"key":"2025010703510641900_r13","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1086\/425021","article-title":"Interleukin (IL)-12 and IL-23 are key cytokines for immunity against Salmonella in humans","volume":"190","author":"MacLennan","year":"2004","journal-title":"J. Infect. Dis."},{"key":"2025010703510641900_r14","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.tube.2004.09.011","article-title":"Control of human host immunity to mycobacteria","volume":"85","author":"Ottenhoff","year":"2005","journal-title":"Tuberculosis (Edinb.)"},{"key":"2025010703510641900_r15","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.micinf.2005.10.032","article-title":"Human host genetic factors in mycobacterial and Salmonella infection: lessons from single gene disorders in IL-12\/IL-23-dependent signaling that affect innate and adaptive immunity","volume":"8","author":"van de Vosse","year":"2006","journal-title":"Microbes Infect."},{"key":"2025010703510641900_r16","doi-asserted-by":"crossref","first-page":"e112","DOI":"10.1093\/cid\/ciw360","article-title":"2016 Infectious Diseases Society of America (IDSA) clinical practice guideline for the treatment of coccidioidomycosis","volume":"63","author":"Galgiani","year":"2016","journal-title":"Clin. Infect. Dis."},{"key":"2025010703510641900_r17","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3201\/eid2403.170623","article-title":"Coccidioidomycosis outbreaks, United States and Worldwide, 1940\u20132015","volume":"24","author":"Freedman","year":"2018","journal-title":"Emerg. Infect. Dis."},{"key":"2025010703510641900_r18","doi-asserted-by":"crossref","first-page":"ofaa623","DOI":"10.1093\/ofid\/ofaa623","article-title":"Clinical and economic burden of Valley Fever in Arizona: an incidence-based cost-of-illness analysis","volume":"8","author":"Grizzle","year":"2021","journal-title":"Open Forum Infect. Dis."},{"key":"2025010703510641900_r19","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.3390\/ijerph16071113","article-title":"The rise of Valley Fever: prevalence and cost burden of coccidioidomycosis infection in California","volume":"16","author":"Wilson","year":"2019","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"2025010703510641900_r20","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3201\/eid1563.081007","article-title":"Coccidioidal pneumonia, Phoenix, Arizona, USA, 2000\u20132004","volume":"15","author":"Kim","year":"2009","journal-title":"Emerg. Infect. Dis."},{"key":"2025010703510641900_r21","doi-asserted-by":"crossref","first-page":"958","DOI":"10.3201\/eid1206.060028","article-title":"Coccidioidomycosis as a common cause of community-acquired pneumonia","volume":"12","author":"Valdivia","year":"2006","journal-title":"Emerg. Infect. Dis."},{"key":"2025010703510641900_r22","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1093\/mmy\/myy019","article-title":"Coccidioidomycosis in selected immunosuppressed hosts","volume":"57","author":"Blair","year":"2019","journal-title":"Med. Mycol."},{"key":"2025010703510641900_r23","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.amjmed.2008.12.024","article-title":"The spectrum and presentation of disseminated coccidioidomycosis","volume":"122","author":"Adam","year":"2009","journal-title":"Am. J. Med."},{"key":"2025010703510641900_r24","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.3201\/eid1809.120151","article-title":"Hospitalizations associated with disseminated coccidioidomycosis, Arizona and California, USA","volume":"18","author":"Seitz","year":"2012","journal-title":"Emerg. Infect. Dis."},{"key":"2025010703510641900_r25","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3201\/eid2302.160505","article-title":"Risk factors for disseminated coccidioidomycosis, United States","volume":"23","author":"Odio","year":"2017","journal-title":"Emerg. Infect. Dis."},{"key":"2025010703510641900_r26","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.jaci.2015.07.003","article-title":"Endemic mycoses in patients with STAT3-mutated hyper-IgE (Job) syndrome","volume":"136","author":"Odio","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025010703510641900_r27","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.jaci.2013.01.052","article-title":"Signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations and disseminated coccidioidomycosis and histoplasmosis","volume":"131","author":"Sampaio","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025010703510641900_r28","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1086\/605532","article-title":"Refractory disseminated coccidioidomycosis and mycobacteriosis in interferon-\u03b3 receptor 1 deficiency","volume":"49","author":"Vinh","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"2025010703510641900_r29","doi-asserted-by":"crossref","first-page":"e99","DOI":"10.1093\/cid\/ciq215","article-title":"Interleukin-12 receptor \u03b21 deficiency predisposing to disseminated coccidioidomycosis","volume":"52","author":"Vinh","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"2025010703510641900_r30","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1016\/j.vaccine.2018.04.026","article-title":"Viable spores of Coccidioides posadasii \u0394cps1 are required for vaccination and provide long lasting immunity","volume":"36","author":"Shubitz","year":"2018","journal-title":"Vaccine"},{"issue":"W1","key":"2025010703510641900_r31","doi-asserted-by":"crossref","first-page":"W242","DOI":"10.1093\/nar\/gky354","article-title":"CRISPOR: intuitive guide selection for CRISPR\/Cas9 genome editing experiments and screens","volume":"46","author":"Concordet","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"2025010703510641900_r32","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/infdis\/jiaa419","article-title":"A chronic murine disease model of coccidioidomycosis using Coccidioides posadasii, strain 1038","volume":"223","author":"Shubitz","year":"2021","journal-title":"J. Infect. Dis."},{"key":"2025010703510641900_r33","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1016\/j.vaccine.2014.05.013","article-title":"IFN-\u03b3, but not IL-17A, is required for survival during secondary pulmonary Francisella tularensis live vaccine stain infection","volume":"32","author":"Roberts","year":"2014","journal-title":"Vaccine"},{"key":"2025010703510641900_r34","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3389\/fimmu.2017.00206","article-title":"Efficacy of resistance to Francisella imparted by ITY\/NRAMP\/SLC11A1 depends on route of infection","volume":"8","author":"Powell","year":"2017","journal-title":"Front. Immunol."},{"key":"2025010703510641900_r35","doi-asserted-by":"crossref","first-page":"676","DOI":"10.7326\/0003-4819-133-9-200011070-00009","article-title":"Comparison of oral fluconazole and itraconazole for progressive, nonmeningeal coccidioidomycosis. A randomized, double-blind trial","volume":"133","author":"Galgiani","year":"2000","journal-title":"Ann. Intern. Med."},{"key":"2025010703510641900_r36","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1002\/humu.21517","article-title":"dbNSFP: a lightweight database of human nonsynonymous SNPs and their functional predictions","volume":"32","author":"Liu","year":"2011","journal-title":"Hum. Mutat."},{"key":"2025010703510641900_r37","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/humu.22932","article-title":"dbNSFP v3.0: a one-stop database of functional predictions and annotations for human nonsynonymous and splice-site SNVs","volume":"37","author":"Liu","year":"2016","journal-title":"Hum. Mutat."},{"key":"2025010703510641900_r38","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41586-020-2308-7","article-title":"The mutational constraint spectrum quantified from variation in 141,456 humans. [Published erratum appears in 2021 Nature 590: E53.]","volume":"581","author":"Karczewski","year":"2020","journal-title":"Nature"},{"key":"2025010703510641900_r39","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1128\/iai.14.6.1356-1368.1976","article-title":"Lung weight parallels disease severity in experimental coccidioidomycosis","volume":"14","author":"Huppert","year":"1976","journal-title":"Infect. Immun."},{"key":"2025010703510641900_r40","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1038\/s41467-020-15172-5","article-title":"Transcription factor p73 regulates Th1 differentiation","volume":"11","author":"Ren","year":"2020","journal-title":"Nat. Commun."},{"key":"2025010703510641900_r41","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.coi.2007.10.005","article-title":"Novel primary immunodeficiencies revealed by the investigation of paediatric infectious diseases","volume":"20","author":"Bustamante","year":"2008","journal-title":"Curr. Opin. Immunol."},{"key":"2025010703510641900_r42","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1093\/cid\/cit722","article-title":"Clinical features of candidiasis in patients with inherited interleukin 12 receptor \u03b21 deficiency","volume":"58","author":"Ouederni","year":"2014","journal-title":"Clin. Infect. Dis."},{"key":"2025010703510641900_r43","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1086\/432120","article-title":"Disseminated histoplasmosis in persons with interferon-\u03b3 receptor 1 deficiency","volume":"41","author":"Zerbe","year":"2005","journal-title":"Clin. Infect. Dis."},{"key":"2025010703510641900_r44","doi-asserted-by":"crossref","first-page":"e1003768","DOI":"10.1371\/journal.ppat.1003768","article-title":"Novel strategies to enhance vaccine immunity against coccidioidomycosis","volume":"9","author":"Cole","year":"2013","journal-title":"PLoS Pathog."},{"key":"2025010703510641900_r45","doi-asserted-by":"crossref","first-page":"e00112-19","DOI":"10.1128\/CMR.00112-19","article-title":"Early events in coccidioidomycosis","volume":"33","author":"Donovan","year":"2019","journal-title":"Clin. Microbiol. Rev."},{"key":"2025010703510641900_r46","doi-asserted-by":"crossref","first-page":"e00597-12","DOI":"10.1128\/mBio.00597-12","article-title":"Dectin-1 is required for resistance to coccidioidomycosis in mice","volume":"4","author":"Viriyakosol","year":"2013","journal-title":"MBio"},{"key":"2025010703510641900_r47","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1128\/IAI.00459-09","article-title":"A genetically engineered live attenuated vaccine of Coccidioides posadasii protects BALB\/c mice against coccidioidomycosis","volume":"77","author":"Xue","year":"2009","journal-title":"Infect. Immun."},{"key":"2025010703510641900_r48","doi-asserted-by":"crossref","first-page":"5453","DOI":"10.4049\/jimmunol.1001153","article-title":"IL-23 and IL-17A, but not IL-12 and IL-22, are required for optimal skin host defense against Candida albicans","volume":"185","author":"Kagami","year":"2010","journal-title":"J. Immunol."},{"key":"2025010703510641900_r49","doi-asserted-by":"crossref","first-page":"5402","DOI":"10.4049\/jimmunol.1101377","article-title":"IL-23 is required for long-term control of Mycobacterium tuberculosis and B cell follicle formation in the infected lung","volume":"187","author":"Khader","year":"2011","journal-title":"J. Immunol."},{"key":"2025010703510641900_r50","doi-asserted-by":"crossref","first-page":"199","DOI":"10.12788\/cutis.0088","article-title":"Risk for deep fungal infections during IL-17 and IL-23 inhibitor therapy for psoriasis","volume":"106","author":"Lee","year":"2020","journal-title":"Cutis"},{"key":"2025010703510641900_r51","doi-asserted-by":"crossref","first-page":"e1008115","DOI":"10.1371\/journal.ppat.1008115","article-title":"IL-23 supports host defense against systemic Candida albicans infection by ensuring myeloid cell survival","volume":"15","author":"Nur","year":"2019","journal-title":"PLoS Pathog."},{"key":"2025010703510641900_r52","doi-asserted-by":"crossref","first-page":"8684","DOI":"10.4049\/jimmunol.177.12.8684","article-title":"Interleukin-23 restores immunity to Mycobacterium tuberculosis infection in IL-12p40-deficient mice and is not required for the development of IL-17-secreting T cell responses","volume":"177","author":"Wozniak","year":"2006","journal-title":"J. Immunol."},{"key":"2025010703510641900_r53","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1086\/315142","article-title":"Interleukin-4 causes susceptibility to invasive pulmonary aspergillosis through suppression of protective type I responses","volume":"180","author":"Cenci","year":"1999","journal-title":"J. Infect. Dis."},{"key":"2025010703510641900_r54","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1128\/IAI.71.7.3787-3793.2003","article-title":"Overexpression of interleukin-4 in lungs of mice impairs elimination of Histoplasma capsulatum","volume":"71","author":"Gildea","year":"2003","journal-title":"Infect. Immun."},{"key":"2025010703510641900_r55","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1002\/eji.1830250614","article-title":"Interleukin-4 and -10 exacerbate candidiasis in mice","volume":"25","author":"Tonnetti","year":"1995","journal-title":"Eur. J. Immunol."}],"container-title":["ImmunoHorizons"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/immunohorizons\/article-pdf\/6\/2\/130\/61339539\/ih2200007.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/immunohorizons\/article-pdf\/6\/2\/130\/61339539\/ih2200007.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T03:56:33Z","timestamp":1736222193000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/immunohorizons\/article\/6\/2\/130\/7816773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,1]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2,1]]}},"URL":"https:\/\/doi.org\/10.4049\/immunohorizons.2200007","relation":{},"ISSN":["2573-7732"],"issn-type":[{"value":"2573-7732","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,2]]},"published":{"date-parts":[[2022,2,1]]}}}