{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T08:18:20Z","timestamp":1758961100980,"version":"3.37.3"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":921,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Experimental autoimmune encephalomyelitis (EAE) is an inflammatory autoimmune disease of the CNS that resembles multiple sclerosis and provides a useful animal model for the evaluation of mechanisms of action for potential immunomodulatory therapies. We have previously shown that oral adrenocorticotropic hormone (ACTH) decreased IL-17 in the gut lamina propria and the spleen and increased CD4+ Foxp3+ T regulatory cells and IL-10 in the spleen during EAE in the C57BL\/6 mouse. However, we did not investigate the specific cellular alterations of proinflammatory and anti-inflammatory factors in the CNS. The aim was to determine if oral ACTH would have a similar clinical effect on inflammatory cytokines in the gut and define specific cellular effects in the CNS in an alternative strain of mice. SJL\/J mice were immunized with proteolipid protein peptide 138\u2013151 and gavaged with scrambled ACTH (scrambled \u03b1-melanocyte-stimulating hormone) or ACTH 1\u201339 during ongoing disease. Ingested (oral) ACTH attenuated ongoing clinical EAE disease, decreased IL-6 production, and increased T regulatory cells in the lamina propria and decreased CD4+ and \u03b3\u03b4 IL-17 production in the CNS. Ingested ACTH attenuated EAE clinical disease by decreasing IL-6 in the gut-associated lymphoid tissue and decreasing IL-17 in the CNS.<\/jats:p>","DOI":"10.4049\/immunohorizons.2200023","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T17:05:10Z","timestamp":1658509510000},"page":"497-506","source":"Crossref","is-referenced-by-count":7,"title":["Ingested (Oral) Adrenocorticotropic Hormone Inhibits IL-17 in the Central Nervous System in the Mouse Model of Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis"],"prefix":"10.1093","volume":"6","author":[{"given":"Landon J","family":"Dittel","sequence":"first","affiliation":[{"name":"Department of Neurology, Medical College of Wisconsin , Milwaukee, WI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonnie N","family":"Dittel","sequence":"additional","affiliation":[{"name":"Versiti Blood Research Institute, Medical College of Wisconsin , Milwaukee, WI"},{"name":"Department of Microbiology and Immunology, Medical College of Wisconsin , Milwaukee, WI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3713-8890","authenticated-orcid":false,"given":"Staley A","family":"Brod","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical College of Wisconsin , Milwaukee, WI"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,7,1]]},"reference":[{"key":"2025010703522284100_r1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1749-6632.1965.tb20218.x","article-title":"Encephalitogen-induced inhibition of experimental allergic encephalomyelitis: prevention, suppression, and therapy","volume":"122","author":"Alvord","year":"1965","journal-title":"Ann. 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