{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:14:53Z","timestamp":1789085693066,"version":"build-2803163510"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":890,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Alcohol intoxication combined with burn injury can lead to life-threatening complications, including sepsis, multiple organ failure, and death. After an acute burn, the gastrointestinal system becomes hypoxic because of fluid loss and reduction of intestinal blood flow. This can cause perturbations in the intestinal epithelial barrier, immune function, and the composition of the gut microbiome. Increased gut permeability leads to proinflammatory signaling, contributing to further damage to the intestinal barrier. Recent studies have suggested that IL-27 plays an anti-inflammatory role, which may be beneficial in intestinal barrier repair. Therefore, in this study, we examined the effect of ethanol and burn injury on IL-27 in the small intestine, as well as the potential beneficial role of IL-27 in restoring the intestinal barrier after intoxication and burn. Male C57BL\/6 mice were gavaged with 2.9 g\/kg ethanol before receiving a \u223c12.5% total body surface area scald burn with or without rIL-27 in resuscitation fluid. Our results demonstrate that IL-27\u2013producing cells are reduced in the small intestine after injury. When IL-27 is supplemented in resuscitation fluid, we were able to restore intestinal barrier integrity and transit, mediated through increased intestinal epithelial cell proliferation, reduced inflammatory cytokines, and increased anti-inflammatory cytokine IL-10. We also observed increased gene expression of tight junction proteins. These findings suggest that IL-27 may be a contributor to maintaining proper intestinal barrier function after injury through multiple mechanisms, including preventing excess inflammation and promoting intestinal epithelial cell proliferation and tight junction integrity.<\/jats:p>","DOI":"10.4049\/immunohorizons.2200032","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T16:55:14Z","timestamp":1660668914000},"page":"600-613","source":"Crossref","is-referenced-by-count":10,"title":["IL-27 Promotes Intestinal Barrier Integrity following Ethanol Intoxication and Burn Injury"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4869-1889","authenticated-orcid":false,"given":"Marisa E","family":"Luck","sequence":"first","affiliation":[{"name":"Alcohol Research Program, Stritch School of Medicine, Loyola University Chicago Health Sciences Division , Maywood, IL"},{"name":"Burn and Shock Trauma Research Institute, Stritch School of Medicine, Loyola University Chicago Health Sciences Division , Maywood, IL"},{"name":"Integrative Cell Biology Program, Stritch School of Medicine, Loyola University Chicago Health Sciences Division , Maywood, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5260-1850","authenticated-orcid":false,"given":"Xiaoling","family":"Li","sequence":"additional","affiliation":[{"name":"Alcohol Research Program, Stritch School of Medicine, Loyola University Chicago Health Sciences Division , Maywood, IL"},{"name":"Burn and Shock Trauma Research Institute, Stritch School of Medicine, Loyola University Chicago Health Sciences Division , Maywood, IL"},{"name":"Department of Surgery, Stritch School of Medicine, Loyola University Chicago Health Sciences Division , Maywood, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6345-3758","authenticated-orcid":false,"given":"Caroline J","family":"Herrnreiter","sequence":"additional","affiliation":[{"name":"Alcohol Research Program, Stritch School of Medicine, Loyola University Chicago Health Sciences Division , Maywood, IL"},{"name":"Burn and Shock Trauma Research Institute, Stritch School of Medicine, Loyola University Chicago Health Sciences Division , Maywood, IL"},{"name":"Biochemistry and Molecular Biology Program, Stritch School of Medicine, Loyola University Chicago Health Sciences Division , Maywood, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6590-3759","authenticated-orcid":false,"given":"Abigail R","family":"Cannon","sequence":"additional","affiliation":[{"name":"Alcohol Research Program, Stritch School of Medicine, Loyola University Chicago Health Sciences Division , Maywood, IL"},{"name":"Burn and Shock Trauma Research Institute, Stritch School of Medicine, Loyola University Chicago Health Sciences Division , Maywood, IL"},{"name":"Department of Surgery, Stritch School of Medicine, Loyola University Chicago Health Sciences Division , Maywood, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1152-7145","authenticated-orcid":false,"given":"Mashkoor A","family":"Choudhry","sequence":"additional","affiliation":[{"name":"Alcohol Research Program, Stritch School of Medicine, Loyola University Chicago Health Sciences Division , Maywood, IL"},{"name":"Burn and Shock Trauma Research Institute, Stritch School of Medicine, Loyola University Chicago Health Sciences Division , Maywood, IL"},{"name":"Integrative Cell Biology Program, Stritch School of Medicine, Loyola University Chicago Health Sciences Division , Maywood, IL"},{"name":"Department of Surgery, Stritch School of Medicine, Loyola University Chicago Health Sciences Division , Maywood, IL"},{"name":"Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago Health Sciences Division , Maywood, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,1]]},"reference":[{"key":"2025010703530508100_r1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1097\/01.ALC.0000057946.57330.F7","article-title":"Mechanisms of alcohol-induced tissue injury","volume":"27","author":"Molina","year":"2003","journal-title":"Alcohol. 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