{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T01:58:39Z","timestamp":1792979919937,"version":"4.5.0"},"reference-count":118,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":617,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-aged individuals with ovaries. It is associated with anovulation and increased risk to fertility and metabolic, cardiovascular, and psychological health. The pathophysiology of PCOS is still inadequately understood, although there is evidence of persistent low-grade inflammation, which correlates with associated visceral obesity. Elevated proinflammatory cytokine markers and altered immune cells have been reported in PCOS and raise the possibility that immune factors contribute to ovulatory dysfunction. Because normal ovulation is modulated by immune cells and cytokines in the ovarian microenvironment, the endocrine and metabolic abnormalities associated with PCOS orchestrate the accompanying adverse effects on ovulation and implantation. This review evaluates the current literature on the relationship between PCOS and immune abnormalities, with a focus on emerging research in the field.<\/jats:p>","DOI":"10.4049\/immunohorizons.2200033","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T15:37:07Z","timestamp":1684337827000},"page":"323-332","source":"Crossref","is-referenced-by-count":54,"title":["Immune Dysfunction in Polycystic Ovary Syndrome"],"prefix":"10.1093","volume":"7","author":[{"given":"Soma","family":"Banerjee","sequence":"first","affiliation":[{"name":"Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Wisconsin\u2013Madison , Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura G","family":"Cooney","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Wisconsin\u2013Madison , Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1946-6436","authenticated-orcid":false,"given":"Aleksandar K","family":"Stanic","sequence":"additional","affiliation":[{"name":"Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Wisconsin\u2013Madison , Madison, WI"},{"name":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Wisconsin\u2013Madison , Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"key":"2025010703553013600_r1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","author":"Rotterdam ESHRE\/ASRM-Sponsored PCOS consensus workshop group","year":"2004","journal-title":"Hum. 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