{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T21:48:37Z","timestamp":1755035317891,"version":"3.37.3"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":890,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Malaria-induced bacteremia has been shown to result from intestinal mast cell (MC) activation. The appearance of MCs in the ileum and increased intestinal permeability to enteric bacteria are preceded by an early Th2-biased host immune response to infection, characterized by the appearance of IL-4, IL-10, mast cell protease (Mcpt)1 and Mcpt4, and increased circulating basophils and eosinophils. Given the functional similarities of basophils and MCs in the context of allergic inflammation and the capacity of basophils to produce large amounts of IL-4, we sought to define the role of basophils in increased intestinal permeability, in MC influx, and in the development of bacteremia in the context of malaria. Upon infection with nonlethal Plasmodium yoelii yoelii 17XNL, Basoph8 \u00d7 ROSA-DT\u03b1 mice or baso (\u2212) mice that lack basophils exhibited increased intestinal permeability and increased ileal MC numbers, without any increase in bacterial 16S ribosomal DNA copy numbers in the blood, relative to baso (+) mice. Analysis of cytokines, chemokines, and MC-associated factors in the ileum revealed significantly increased TNF-\u03b1 and IL-13 at day 6 postinfection in baso (\u2212) mice compared with baso (+) mice. Moreover, network analysis of significantly correlated host immune factors revealed profound differences between baso (\u2212) and baso (+) mice following infection in both systemic and ileal responses to parasites and translocated bacteria. Finally, basophil depletion was associated with significantly increased gametocytemia and parasite transmission to Anopheles mosquitoes, suggesting that basophils play a previously undescribed role in controlling gametocytemia and, in turn, mammalian host-to-mosquito parasite transmission.<\/jats:p>","DOI":"10.4049\/immunohorizons.2200055","type":"journal-article","created":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T13:40:12Z","timestamp":1660570812000},"page":"581-599","source":"Crossref","is-referenced-by-count":9,"title":["Basophil Depletion Alters Host Immunity, Intestinal Permeability, and Mammalian Host-to-Mosquito Transmission in Malaria"],"prefix":"10.1093","volume":"6","author":[{"given":"Erinn L","family":"Donnelly","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, University of Idaho , Moscow, ID"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora","family":"C\u00e9spedes","sequence":"additional","affiliation":[{"name":"Department of Entomology, Plant Pathology and Nematology, University of Idaho , Moscow, ID"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gretchen","family":"Hansten","sequence":"additional","affiliation":[{"name":"Department of Entomology, Plant Pathology and Nematology, University of Idaho , Moscow, ID"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delaney","family":"Wagers","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Idaho , Moscow, ID"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M","family":"Briggs","sequence":"additional","affiliation":[{"name":"Department of Entomology, Plant Pathology and Nematology, University of Idaho , Moscow, ID"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casey","family":"Lowder","sequence":"additional","affiliation":[{"name":"Department of Entomology, Plant Pathology and Nematology, University of Idaho , Moscow, ID"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2476-6233","authenticated-orcid":false,"given":"Joseph","family":"Schauer","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy and Clinical Immunology, University of California , Davis, Davis, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah M","family":"Garrison","sequence":"additional","affiliation":[{"name":"Department of Entomology, Plant Pathology and Nematology, University of Idaho , Moscow, ID"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori","family":"Haapanen","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy and Clinical Immunology, University of California , Davis, Davis, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1193-5875","authenticated-orcid":false,"given":"Judy","family":"Van de Water","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy and Clinical Immunology, University of California , Davis, Davis, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley","family":"Luckhart","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Idaho , Moscow, ID"},{"name":"Department of Entomology, Plant Pathology and Nematology, University of Idaho , Moscow, ID"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,8,1]]},"reference":[{"article-title":"World malaria report 2021","year":"2021","author":"World Health Organization","key":"2025010703530924900_r1"},{"key":"2025010703530924900_r2","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/S0140-6736(11)60888-X","article-title":"Relation between falciparum malaria and bacteraemia in Kenyan children: a population-based, case-control study and a longitudinal study","volume":"378","author":"Scott","year":"2011","journal-title":"Lancet"},{"key":"2025010703530924900_r3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1741-7015-12-31","article-title":"Invasive bacterial co-infection in African children with Plasmodium falciparum malaria: a systematic review","volume":"12","author":"Church","year":"2014","journal-title":"BMC Med"},{"key":"2025010703530924900_r4","doi-asserted-by":"crossref","first-page":"ofw028","DOI":"10.1093\/ofid\/ofw028","article-title":"High frequency of clinically significant bacteremia in adults hospitalized with falciparum malaria","volume":"3","author":"Nyein","year":"2016","journal-title":"Open Forum Infect. 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