{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T23:07:30Z","timestamp":1740179250649,"version":"3.37.3"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":890,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We have recently demonstrated that basophils are protective against intestinal permeability during malaria and contribute to reduced parasite transmission to mosquitoes. Given that IL-18 is an early cytokine\/alarmin in malaria and has been shown to activate basophils, we sought to determine the role of the basophil IL-18R in this protective phenotype. To address this, we infected control [IL18rflox\/flox or basoIL-18R (+)] mice and mice with basophils lacking the IL-18R [IL18rflox\/flox \u00d7 Basoph8 or basoIL-18R (\u2212)] with Plasmodium yoelii yoelii 17XNL, a nonlethal strain of mouse malaria. Postinfection (PI), intestinal permeability, ileal mastocytosis, bacteremia, and levels of ileal and plasma cytokines and chemokines were measured through 10 d PI. BasoIL-18R (\u2212) mice exhibited greater intestinal permeability relative to basoIL-18R (+) mice, along with increased plasma levels of proinflammatory cytokines at a single time point PI, day 4 PI, a pattern not observed in basoIL-18R (+) mice. Surprisingly, mosquitoes fed on basoIL-18R (\u2212) mice became infected less frequently than mosquitoes fed on basoIL-18R (+) mice, with no difference in gametocytemia, a pattern that was distinct from that observed previously with basophil-depleted mice. These findings suggest that early basophil-dependent protection of the intestinal barrier in malaria is mediated by IL-18, and that basophil IL-18R\u2013dependent signaling differentially regulates the inflammatory response to infection and parasite transmission.<\/jats:p>","DOI":"10.4049\/immunohorizons.2200057","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T16:55:12Z","timestamp":1660928112000},"page":"630-641","source":"Crossref","is-referenced-by-count":4,"title":["The Basophil IL-18 Receptor Precisely Regulates the Host Immune Response and Malaria-Induced Intestinal Permeability and Alters Parasite Transmission to Mosquitoes without Effect on Gametocytemia"],"prefix":"10.1093","volume":"6","author":[{"given":"Erinn L","family":"Donnelly","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, University of Idaho , Moscow, ID"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora","family":"C\u00e9spedes","sequence":"additional","affiliation":[{"name":"Department of Entomology, Plant Pathology and Nematology, University of Idaho , Moscow, ID"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gretchen","family":"Hansten","sequence":"additional","affiliation":[{"name":"Department of Entomology, Plant Pathology and Nematology, University of Idaho , Moscow, ID"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delaney","family":"Wagers","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Idaho , Moscow, ID"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M","family":"Briggs","sequence":"additional","affiliation":[{"name":"Department of Entomology, Plant Pathology and Nematology, University of Idaho , Moscow, ID"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casey","family":"Lowder","sequence":"additional","affiliation":[{"name":"Department of Entomology, Plant Pathology and Nematology, University of Idaho , Moscow, ID"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2476-6233","authenticated-orcid":false,"given":"Joseph","family":"Schauer","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy and Clinical Immunology, University of California , Davis, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori","family":"Haapanen","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy and Clinical Immunology, University of California , Davis, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judy","family":"Van de Water","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy and Clinical Immunology, University of California , Davis, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirley","family":"Luckhart","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Idaho , Moscow, ID"},{"name":"Department of Entomology, Plant Pathology and Nematology, University of Idaho , Moscow, ID"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,8,1]]},"reference":[{"year":"2021","author":"World Health Organization","key":"2025010703530295500_r1"},{"key":"2025010703530295500_r2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1741-7015-12-31","article-title":"Invasive bacterial co-infection in African children with Plasmodium falciparum malaria: a systematic review","volume":"12","author":"Church","year":"2014","journal-title":"BMC Med"},{"key":"2025010703530295500_r3","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/S0140-6736(11)60888-X","article-title":"Relation between falciparum malaria and bacteraemia in Kenyan children: a population-based, case-control study and a longitudinal study","volume":"378","author":"Scott","year":"2011","journal-title":"Lancet"},{"key":"2025010703530295500_r4","doi-asserted-by":"crossref","first-page":"688","DOI":"10.4269\/ajtmh.18-0378","article-title":"Antibiotic therapy in adults with malaria (ANTHEM): high rate of clinically significant bacteremia in hospitalized adults diagnosed with falciparum malaria","volume":"99","author":"Aung","year":"2018","journal-title":"Am. 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