{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:48:44Z","timestamp":1790635724134,"version":"4.1.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":829,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Multiple organ damage is common in patients with severe COVID-19, even though the underlying pathogenic mechanisms remain unclear. Acute viral infection typically activates type I IFN (IFN-I) signaling. The antiviral role of IFN-I is well characterized in vitro. However, our understanding of how IFN-I regulates host immune response to SARS-CoV-2 infection in vivo is incomplete. Using a human ACE2-transgenic mouse model, we show in the present study that IFN-I receptor signaling is essential for protection against the acute lethality of SARS-CoV-2 in mice. Interestingly, although IFN-I signaling limits viral replication in the lung, the primary infection site, it is dispensable for efficient viral clearance at the adaptive phase of SARS-CoV-2 infection. Conversely, we found that in the absence of IFN-I receptor signaling, the extreme animal lethality is consistent with heightened infectious virus and prominent pathological manifestations in the brain. Taken together, our results in this study demonstrate that IFN-I receptor signaling is required for restricting virus neuroinvasion, thereby mitigating COVID-19 severity.<\/jats:p>","DOI":"10.4049\/immunohorizons.2200065","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T15:20:14Z","timestamp":1665501614000},"page":"716-721","source":"Crossref","is-referenced-by-count":6,"title":["Type I IFN Signaling Protects Mice from Lethal SARS-CoV-2 Neuroinvasion"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0045-9669","authenticated-orcid":false,"given":"Md Bashir","family":"Uddin","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch , Galveston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9557-1847","authenticated-orcid":false,"given":"Yuejin","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch , Galveston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjun","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch , Galveston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3990-0343","authenticated-orcid":false,"given":"Sunil","family":"Palani","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch , Galveston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"McKelvey","sequence":"additional","affiliation":[{"name":"Department of Experimental Pathology, University of Texas Medical Branch , Galveston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott C","family":"Weaver","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch , Galveston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keer","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Texas Medical Branch , Galveston, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,10,1]]},"reference":[{"key":"2025010703532344100_r1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.antiviral.2013.05.007","article-title":"Type I interferon limits influenza virus-induced acute lung injury by regulation of excessive inflammation in mice","volume":"99","author":"Arimori","year":"2013","journal-title":"Antiviral Res."},{"key":"2025010703532344100_r2","doi-asserted-by":"crossref","first-page":"6604","DOI":"10.1128\/JVI.00009-13","article-title":"Tropism of and innate immune responses to the novel human betacoronavirus lineage C virus in human ex vivo respiratory organ cultures","volume":"87","author":"Chan","year":"2013","journal-title":"J. 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