{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T18:37:18Z","timestamp":1776451038465,"version":"3.51.2"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":706,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Notch ligands present during interactions between T cells and dendritic cells (DCs) dictate cell phenotype through a myriad of effects including the induction of T cell regulation, survival, and cytokine response. The presence of Notch ligands on DCs varies with the context of the inflammatory response; Jagged-1 is constitutively expressed, whereas Delta-like 1 and Delta-like 4 are induced in response to pathogen exposure. Although Delta-like and Jagged ligands send different signals through the same Notch receptor, the role of these two ligands in peripheral T cell immunity is not clear. The goal of our studies was to determine the role of Jagged-1 in the pathogen-free inflammation induced by OVA during allergic airway disease in mice. Our studies show that a deletion in DC-expressed Jagged-1 causes a significant increase in cytokine production, resulting in increased mucus production and increased eosinophilia in the lungs of mice sensitized and challenged with OVA. We also observed that a reduction of Jagged-1 expression is correlated with increased expression of the Notch 1 receptor on the surface of CD4+ T cells in both the lung and lymph node. Through transfer studies using OT-II transgenic T cells, we demonstrate that Jagged-1 represses the expansion of CD44+CD62L+CCR7+ memory cells and promotes the expansion of CD44+CD62L\u2212 effector cells, but it has no effect on the expansion of naive cells during allergic airway disease. These data suggest that Jagged-1 may have different roles in Ag-specific T cell responses, depending on the maturity of the stimulated T cell.<\/jats:p>","DOI":"10.4049\/immunohorizons.2300001","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T15:22:51Z","timestamp":1675351371000},"page":"168-176","source":"Crossref","is-referenced-by-count":1,"title":["Jagged-1 Reduces Th2 Inflammation and Memory Cell Expansion in Allergic Airway Disease"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4278-1741","authenticated-orcid":false,"given":"Soichiro","family":"Kimura","sequence":"first","affiliation":[{"name":"Department of Microbiology and Infectious Diseases, Toho University School of Medicine , Tokyo ,","place":["Japan"]},{"name":"Division of Infection Prevention and Control, Faculty of Pharmaceutical Sciences, Shonan University of Medical Sciences , Kanagawa ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2928-4249","authenticated-orcid":false,"given":"Zadia","family":"Dupee","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida , Gainesville, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"Lima","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida , Gainesville, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9542-5874","authenticated-orcid":false,"given":"Ronald","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan , Ann Arbor, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3643-8031","authenticated-orcid":false,"given":"Soha","family":"Kazmi","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida , Gainesville, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2151-8090","authenticated-orcid":false,"given":"Nickolas","family":"Diodati","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida , Gainesville, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2403-6481","authenticated-orcid":false,"given":"Nicholas W","family":"Lukacs","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan , Ann Arbor, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven L","family":"Kunkel","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan , Ann Arbor, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3338-0655","authenticated-orcid":false,"given":"Matthew","family":"Schaller","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Florida , Gainesville, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,2,2]]},"reference":[{"key":"2025010703544980000_r1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/JLB.1RI0520-138R","article-title":"Notch signaling at the crossroads of innate and adaptive immunity","volume":"109","author":"Vanderbeck","year":"2021","journal-title":"J. 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Med."},{"key":"2025010703544980000_r5","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.clim.2017.10.005","article-title":"Overexpression of Notch ligand Delta-like-1 by dendritic cells enhances their immunoregulatory capacity and exerts antiallergic effects on Th2-mediated allergic asthma in mice","volume":"187","author":"Lee","year":"2018","journal-title":"Clin. Immunol."},{"key":"2025010703544980000_r6","doi-asserted-by":"crossref","first-page":"5835","DOI":"10.4049\/jimmunol.1000175","article-title":"Notch ligand delta-like 4 regulates development and pathogenesis of allergic airway responses by modulating IL-2 production and Th2 immunity","volume":"185","author":"Jang","year":"2010","journal-title":"J. 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