{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T23:07:38Z","timestamp":1740179258105,"version":"3.37.3"},"reference-count":139,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":617,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Links between repeated microbial infections and B cell chronic lymphocytic leukemia (B-CLL) have been proposed but not tested directly. This study examines how prolonged exposure to a human fungal pathogen impacts B-CLL development in E\u00b5-hTCL1\u2013transgenic mice. Monthly lung exposure to inactivated Coccidioides arthroconidia, agents of Valley fever, altered leukemia development in a species-specific manner, with Coccidioides posadasii hastening B-CLL diagnosis\/progression in a fraction of mice and Coccidioides immitis delaying aggressive B-CLL development, despite fostering more rapid monoclonal B cell lymphocytosis. Overall survival did not differ significantly between control and C. posadasii\u2013treated cohorts but was significantly extended in C. immitis\u2013exposed mice. In vivo doubling time analyses of pooled B-CLL showed no difference in growth rates of early and late leukemias. However, within C. immitis\u2013treated mice, B-CLL manifests longer doubling times, as compared with B-CLL in control or C. posadasii\u2013treated mice, and\/or evidence of clonal contraction over time. Through linear regression, positive relationships were noted between circulating levels of CD5+\/B220low B cells and hematopoietic cells previously linked to B-CLL growth, albeit in a cohort-specific manner. Neutrophils were positively linked to accelerated growth in mice exposed to either Coccidioides species, but not in control mice. Conversely, only C. posadasii\u2013exposed and control cohorts displayed positive links between CD5+\/B220low B cell frequency and abundance of M2 anti-inflammatory monocytes and T cells. The current study provides evidence that chronic lung exposure to fungal arthroconidia affects B-CLL development in a manner dependent on fungal genotype. Correlative studies suggest that fungal species differences in the modulation of nonleukemic hematopoietic cells are involved.<\/jats:p>","DOI":"10.4049\/immunohorizons.2300013","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T15:37:05Z","timestamp":1684337825000},"page":"333-352","source":"Crossref","is-referenced-by-count":0,"title":["B Cell Chronic Lymphocytic Leukemia Development in Mice with Chronic Lung Exposure to <i>Coccidioides<\/i> Fungal Arthroconidia"],"prefix":"10.1093","volume":"7","author":[{"given":"Vanessa","family":"Coyne","sequence":"first","affiliation":[{"name":"Pathogen Microbiome Institute, Northern Arizona University , Flagstaff, AZ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5680-0758","authenticated-orcid":false,"given":"Heather L","family":"Mead","sequence":"additional","affiliation":[{"name":"Pathogen Microbiome Institute, Northern Arizona University , Flagstaff, AZ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4966-7741","authenticated-orcid":false,"given":"Patricia K A","family":"Mongini","sequence":"additional","affiliation":[{"name":"Pathogen Microbiome Institute, Northern Arizona University , Flagstaff, AZ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3439-4517","authenticated-orcid":false,"given":"Bridget M","family":"Barker","sequence":"additional","affiliation":[{"name":"Pathogen Microbiome Institute, Northern Arizona University , Flagstaff, AZ"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,5,17]]},"reference":[{"key":"2025010703554711900_r1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1053\/j.seminoncol.2016.02.013","article-title":"What does it mean I have a monoclonal B-cell lymphocytosis?: recent insights and new challenges","volume":"43","author":"Scarf\u00f2","year":"2016","journal-title":"Semin. Oncol."},{"key":"2025010703554711900_r2","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1182\/blood.2021012890","article-title":"High-risk subtypes of chronic lymphocytic leukemia are detectable as early as 16 years prior to diagnosis","volume":"139","author":"Kolijn","year":"2022","journal-title":"Blood"},{"key":"2025010703554711900_r3","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1084\/jem.20040544","article-title":"Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia","volume":"200","author":"Messmer","year":"2004","journal-title":"J. Exp. Med."},{"key":"2025010703554711900_r4","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.hoc.2013.01.002","article-title":"Biology of chronic lymphocytic leukemia in different microenvironments: clinical and therapeutic implications","volume":"27","author":"Herishanu","year":"2013","journal-title":"Hematol. Oncol. Clin. North Am."},{"key":"2025010703554711900_r5","doi-asserted-by":"crossref","first-page":"901","DOI":"10.4049\/jimmunol.1403189","article-title":"TLR-9 and IL-15 synergy promotes the in vitro clonal expansion of chronic lymphocytic leukemia B cells","volume":"195","author":"Mongini","year":"2015","journal-title":"J. Immunol."},{"key":"2025010703554711900_r6","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.4049\/jimmunol.1800591","article-title":"Mechanistic insights into CpG DNA and IL-15 synergy in promoting B cell chronic lymphocytic leukemia clonal expansion","volume":"201","author":"Gupta","year":"2018","journal-title":"J. Immunol."},{"key":"2025010703554711900_r7","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.cell.2013.01.019","article-title":"Evolution and impact of subclonal mutations in chronic lymphocytic leukemia","volume":"152","author":"Landau","year":"2013","journal-title":"Cell"},{"key":"2025010703554711900_r8","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/s41375-018-0260-4","article-title":"Exome sequencing of the TCL1 mouse model for CLL reveals genetic heterogeneity and dynamics during disease development","volume":"33","author":"Zaborsky","year":"2019","journal-title":"Leukemia"},{"key":"2025010703554711900_r9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s40364-021-00290-z","article-title":"Immunological and genetic kinetics from diagnosis to clinical progression in chronic lymphocytic leukemia","volume":"9","author":"Jim\u00e9nez","year":"2021","journal-title":"Biomark. Res."},{"key":"2025010703554711900_r10","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1073\/pnas.0813411106","article-title":"Antigen-specific B-1a antibodies induced by Francisella tularensis LPS provide long-term protection against F. tularensis LVS challenge","volume":"106","author":"Cole","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025010703554711900_r11","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1084\/jem.20080979","article-title":"Dual role for B-1a cells in immunity to influenza virus infection","volume":"205","author":"Choi","year":"2008","journal-title":"J. Exp. Med."},{"key":"2025010703554711900_r12","doi-asserted-by":"crossref","first-page":"5755","DOI":"10.4049\/jimmunol.0901638","article-title":"The absence of serum IgM enhances the susceptibility of mice to pulmonary challenge with Cryptococcus neoformans","volume":"184","author":"Subramaniam","year":"2010","journal-title":"J. Immunol."},{"key":"2025010703554711900_r13","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.coi.2018.12.001","article-title":"B-1 cell responses to infections","volume":"57","author":"Smith","year":"2019","journal-title":"Curr. Opin. Immunol."},{"key":"2025010703554711900_r14","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/nyas.12788","article-title":"Protective natural autoantibodies to apoptotic cells: evidence of convergent selection of recurrent innate-like clones","volume":"1362","author":"Silverman","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2025010703554711900_r15","doi-asserted-by":"crossref","first-page":"324","DOI":"10.3389\/fimmu.2016.00324","article-title":"B-1 cell heterogeneity and the regulation of natural and antigen-induced IgM production","volume":"7","author":"Baumgarth","year":"2016","journal-title":"Front. Immunol."},{"key":"2025010703554711900_r16","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri2901","article-title":"The double life of a B-1 cell: self-reactivity selects for protective effector functions","volume":"11","author":"Baumgarth","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"2025010703554711900_r17","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3389\/fimmu.2014.00535","article-title":"B1b cells recognize protective antigens after natural infection and vaccination","volume":"5","author":"Cunningham","year":"2014","journal-title":"Front. Immunol."},{"key":"2025010703554711900_r18","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1084\/jem.20121801","article-title":"A mutated B cell chronic lymphocytic leukemia subset that recognizes and responds to fungi","volume":"210","author":"Hoogeboom","year":"2013","journal-title":"J. Exp. Med."},{"key":"2025010703554711900_r19","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1172\/JCI24387","article-title":"Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity","volume":"115","author":"Herv\u00e9","year":"2005","journal-title":"J. Clin. Invest."},{"key":"2025010703554711900_r20","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.1182\/blood-2011-11-393694","article-title":"Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies","volume":"119","author":"Agathangelidis","year":"2012","journal-title":"Blood"},{"key":"2025010703554711900_r21","doi-asserted-by":"crossref","first-page":"11713","DOI":"10.1073\/pnas.0604564103","article-title":"B cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemia","volume":"103","author":"Yan","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025010703554711900_r22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev-pathol-020712-163955","article-title":"The pathogenesis of chronic lymphocytic leukemia","volume":"9","author":"Zhang","year":"2014","journal-title":"Annu. Rev. Pathol."},{"key":"2025010703554711900_r23","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1172\/JCI19399","article-title":"Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia","volume":"113","author":"Ghiotto","year":"2004","journal-title":"J. Clin. Invest."},{"key":"2025010703554711900_r24","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.1182\/blood-2007-11-125450","article-title":"A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies","volume":"111","author":"Lanemo Myhrinder","year":"2008","journal-title":"Blood"},{"key":"2025010703554711900_r25","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.clim.2016.08.020","article-title":"Chronic lymphocytic leukemia immunoglobulins display bacterial reactivity that converges and diverges from auto-\/poly-reactivity and IGHV mutation status","volume":"172","author":"Hatzi","year":"2016","journal-title":"Clin. Immunol."},{"key":"2025010703554711900_r26","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1182\/blood-2011-08-374058","article-title":"Recombinant antibodies encoded by IGHV1-69 react with pUL32, a phosphoprotein of cytomegalovirus and B-cell superantigen","volume":"119","author":"Steininger","year":"2012","journal-title":"Blood"},{"key":"2025010703554711900_r27","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1182\/blood-2006-08-044008","article-title":"Respiratory tract infections and subsequent risk of chronic lymphocytic leukemia","volume":"109","author":"Landgren","year":"2007","journal-title":"Blood"},{"key":"2025010703554711900_r28","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/leu.2008.379","article-title":"Molecular evidence for EBV and CMV persistence in a subset of patients with chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors","volume":"23","author":"Kostareli","year":"2009","journal-title":"Leukemia"},{"key":"2025010703554711900_r29","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.4049\/jimmunol.0901089","article-title":"Alveolar macrophages transport pathogens to lung draining lymph nodes","volume":"183","author":"Kirby","year":"2009","journal-title":"J. Immunol."},{"key":"2025010703554711900_r30","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1158\/0008-5472.CAN-18-0781","article-title":"TLR signaling is activated in lymph node-resident CLL cells and is only partially inhibited by ibrutinib","volume":"79","author":"Dadashian","year":"2019","journal-title":"Cancer Res."},{"key":"2025010703554711900_r31","doi-asserted-by":"crossref","first-page":"e2012055","DOI":"10.4084\/mjhid.2012.055","article-title":"Toll-like receptors in chronic lymphocytic leukemia","volume":"4","author":"Muzio","year":"2012","journal-title":"Mediterr. J. Hematol. Infect. Dis."},{"key":"2025010703554711900_r32","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1002\/ijc.24832","article-title":"Toll-like receptors on B-CLL cells: expression and functional consequences of their stimulation","volume":"126","author":"Rozkov\u00e1","year":"2010","journal-title":"Int. J. Cancer"},{"key":"2025010703554711900_r33","doi-asserted-by":"crossref","first-page":"6955","DOI":"10.1073\/pnas.102181599","article-title":"Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression","volume":"99","author":"Bichi","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025010703554711900_r34","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1182\/blood-2014-05-577122","article-title":"Mouse models in the study of chronic lymphocytic leukemia pathogenesis and therapy","volume":"124","author":"Simonetti","year":"2014","journal-title":"Blood"},{"key":"2025010703554711900_r35","doi-asserted-by":"crossref","first-page":"4469","DOI":"10.1182\/blood-2009-06-230169","article-title":"Chronic lymphocytic leukemia of Emu-TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression","volume":"114","author":"Enzler","year":"2009","journal-title":"Blood"},{"key":"2025010703554711900_r36","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.micinf.2014.06.011","article-title":"Valley fever: danger lurking in a dust cloud","volume":"16","author":"Johnson","year":"2014","journal-title":"Microbes Infect."},{"key":"2025010703554711900_r37","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.3389\/fimmu.2019.02188","article-title":"The rise of Coccidioides: forces against the dust devil unleashed","volume":"10","author":"Van Dyke","year":"2019","journal-title":"Front. Immunol."},{"key":"2025010703554711900_r38","doi-asserted-by":"crossref","first-page":"e1004762","DOI":"10.1371\/journal.ppat.1004762","article-title":"Dust devil: the life and times of the fungus that causes Valley fever","volume":"11","author":"Lewis","year":"2015","journal-title":"PLoS Pathog."},{"key":"2025010703554711900_r39","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1128\/iai.23.3.681-685.1979","article-title":"Mechanisms of resistance to infection with Coccidioides immitis in mice","volume":"23","author":"Beaman","year":"1979","journal-title":"Infect. Immun."},{"key":"2025010703554711900_r40","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.1128\/IAI.05726-11","article-title":"Vaccine immunity to coccidioidomycosis occurs by early activation of three signal pathways of T helper cell response (Th1, Th2, and Th17)","volume":"79","author":"Hung","year":"2011","journal-title":"Infect. Immun."},{"key":"2025010703554711900_r41","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.1128\/IAI.73.7.3923-3928.2005","article-title":"Cellular immune suppressor activity resides in lymphocyte cell clusters adjacent to granulomata in human coccidioidomycosis","volume":"73","author":"Li","year":"2005","journal-title":"Infect. Immun."},{"key":"2025010703554711900_r42","doi-asserted-by":"crossref","first-page":"5553","DOI":"10.1128\/IAI.00885-08","article-title":"Vaccine-induced cellular immune responses differ from innate responses in susceptible and resistant strains of mice infected with Coccidioides posadasii","volume":"76","author":"Shubitz","year":"2008","journal-title":"Infect. Immun."},{"key":"2025010703554711900_r43","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/imr.12176","article-title":"B10 cell regulation of health and disease","volume":"259","author":"Candando","year":"2014","journal-title":"Immunol. Rev."},{"key":"2025010703554711900_r44","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/leu.2012.165","article-title":"Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function","volume":"27","author":"DiLillo","year":"2013","journal-title":"Leukemia"},{"key":"2025010703554711900_r45","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1093\/mmy\/myy095","article-title":"Update on the Epidemiology of coccidioidomycosis in the United States","volume":"57","author":"McCotter","year":"2019","journal-title":"Med. Mycol."},{"key":"2025010703554711900_r46","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1101\/gr.087551.108","article-title":"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives","volume":"19","author":"Sharpton","year":"2009","journal-title":"Genome Res."},{"key":"2025010703554711900_r47","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1055\/s-0031-1295723","article-title":"Pulmonary coccidioidomycosis","volume":"32","author":"Thompson","year":"2011","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"2025010703554711900_r48","doi-asserted-by":"crossref","first-page":"958","DOI":"10.3201\/eid1206.060028","article-title":"Coccidioidomycosis as a common cause of community-acquired pneumonia","volume":"12","author":"Valdivia","year":"2006","journal-title":"Emerg. Infect. Dis."},{"key":"2025010703554711900_r49","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1080\/21505594.2019.1589363","article-title":"The mysterious desert dwellers: Coccidioides immitis and Coccidioides posadasii, causative fungal agents of coccidioidomycosis","volume":"10","author":"Kollath","year":"2019","journal-title":"Virulence"},{"key":"2025010703554711900_r50","doi-asserted-by":"crossref","first-page":"4558","DOI":"10.1073\/pnas.071406098","article-title":"Biogeographic range expansion into South America by Coccidioides immitis mirrors New World patterns of human migration","volume":"98","author":"Fisher","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025010703554711900_r51","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1128\/EC.00122-15","article-title":"Differences in host innate responses among Coccidioides isolates in a murine model of pulmonary coccidioidomycosis","volume":"14","author":"Lewis","year":"2015","journal-title":"Eukaryot. Cell"},{"key":"2025010703554711900_r52","doi-asserted-by":"crossref","first-page":"e2071","DOI":"10.1038\/cddis.2015.419","article-title":"TCL1 transgenic mouse model as a tool for the study of therapeutic targets and microenvironment in human B-cell chronic lymphocytic leukemia","volume":"7","author":"Bresin","year":"2016","journal-title":"Cell Death Dis."},{"key":"2025010703554711900_r53","doi-asserted-by":"crossref","first-page":"jkac031","DOI":"10.1093\/g3journal\/jkac031","article-title":"A chromosomal-level reference genome of the widely utilized Coccidioides posadasii laboratory strain \u201cSilveira\u201d","volume":"12","author":"de Melo Teixeira","year":"2022","journal-title":"G3 (Bethesda)"},{"key":"2025010703554711900_r54","doi-asserted-by":"crossref","first-page":"e113","DOI":"10.1002\/cpmc.113","article-title":"Proper care and feeding of Coccidioides: a laboratorian\u2019s guide to cultivating the dimorphic stages of C. immitis and C. posadasii","volume":"58","author":"Mead","year":"2020","journal-title":"Curr. Protoc. Microbiol."},{"key":"2025010703554711900_r55","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1158\/0008-5472.CAN-05-3426","article-title":"Effect of rapamycin on mouse chronic lymphocytic leukemia and the development of nonhematopoietic malignancies in Emu-TCL1 transgenic mice","volume":"66","author":"Zanesi","year":"2006","journal-title":"Cancer Res."},{"key":"2025010703554711900_r56","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1182\/asheducation-2011.1.96","article-title":"Nurture versus nature: the microenvironment in chronic lymphocytic leukemia","volume":"2011","author":"Burger","year":"2011","journal-title":"Hematology (Am. Soc. Hematol. Educ. Program)"},{"key":"2025010703554711900_r57","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.3324\/haematol.2012.073080","article-title":"The monocytic population in chronic lymphocytic leukemia shows altered composition and deregulation of genes involved in phagocytosis and inflammation","volume":"98","author":"Maffei","year":"2013","journal-title":"Haematologica"},{"key":"2025010703554711900_r58","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3390\/ijms23010365","article-title":"The role of neutrophils in the pathogenesis of chronic lymphocytic leukemia","volume":"23","author":"Wachowska","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2025010703554711900_r59","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1016\/j.celrep.2016.01.042","article-title":"Targeting macrophages sensitizes chronic lymphocytic leukemia to apoptosis and inhibits disease progression","volume":"14","author":"Galletti","year":"2016","journal-title":"Cell Rep."},{"key":"2025010703554711900_r60","doi-asserted-by":"crossref","first-page":"e00112-19","DOI":"10.1128\/CMR.00112-19","article-title":"Early events in coccidioidomycosis","volume":"33","author":"Donovan","year":"2019","journal-title":"Clin. Microbiol. Rev."},{"key":"2025010703554711900_r61","doi-asserted-by":"crossref","first-page":"630","DOI":"10.3390\/jof7080630","article-title":"Macrophage and dendritic cell activation and polarization in response to Coccidioidesposadasii infection","volume":"7","author":"Diep","year":"2021","journal-title":"J. Fungi (Basel)"},{"key":"2025010703554711900_r62","doi-asserted-by":"crossref","first-page":"581101","DOI":"10.3389\/fcimb.2020.581101","article-title":"Host response to Coccidioides infection: fungal immunity","volume":"10","author":"Diep","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"2025010703554711900_r63","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/leu.2015.305","article-title":"Depletion of CLL-associated patrolling monocytes and macrophages controls disease development and repairs immune dysfunction in vivo","volume":"30","author":"Hanna","year":"2016","journal-title":"Leukemia"},{"key":"2025010703554711900_r64","doi-asserted-by":"crossref","first-page":"516","DOI":"10.3390\/biomedicines8110516","article-title":"Macrophage polarization in chronic lymphocytic leukemia: nurse-like cells are the caretakers of leukemic cells","volume":"8","author":"Mesaros","year":"2020","journal-title":"Biomedicines"},{"key":"2025010703554711900_r65","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.immuni.2017.04.010","article-title":"Understanding spontaneous conversion: the case of the Ly6C\u2212 monocyte","volume":"46","author":"Polletti","year":"2017","journal-title":"Immunity"},{"key":"2025010703554711900_r66","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nri3671","article-title":"Monocytes and macrophages: developmental pathways and tissue homeostasis","volume":"14","author":"Ginhoux","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"2025010703554711900_r67","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1182\/blood-2009-07-235028","article-title":"Comparison of gene expression profiles between human and mouse monocyte subsets","volume":"115","author":"Ingersoll","year":"2010","journal-title":"Blood"},{"key":"2025010703554711900_r68","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1182\/blood-2014-07-589069","article-title":"Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia","volume":"125","author":"Audrito","year":"2015","journal-title":"Blood"},{"key":"2025010703554711900_r69","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3390\/cells10020217","article-title":"Nurse-like cells and chronic lymphocytic leukemia B cells: a mutualistic crosstalk inside tissue microenvironments","volume":"10","author":"Fiorcari","year":"2021","journal-title":"Cells"},{"key":"2025010703554711900_r70","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1182\/blood-2010-05-284984","article-title":"The lymph node microenvironment promotes B-cell receptor signaling, NF-\u03baB activation, and tumor proliferation in chronic lymphocytic leukemia","volume":"117","author":"Herishanu","year":"2011","journal-title":"Blood"},{"key":"2025010703554711900_r71","first-page":"E1500","article-title":"Autoantigen can promote progression to a more aggressive TCL1 leukemia by selecting variants with enhanced B-cell receptor signaling","volume":"110","author":"Chen","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025010703554711900_r72","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1128\/IAI.70.8.4501-4509.2002","article-title":"Dissemination of Mycobacterium tuberculosis is influenced by host factors and precedes the initiation of T-cell immunity","volume":"70","author":"Chackerian","year":"2002","journal-title":"Infect. Immun."},{"key":"2025010703554711900_r73","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.rmed.2016.01.021","article-title":"Thoracic lymphadenopathy in benign diseases: a state of the art review","volume":"112","author":"Nin","year":"2016","journal-title":"Respir. Med."},{"key":"2025010703554711900_r74","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1182\/blood-2014-07-587790","article-title":"Two types of BCR interactions are positively selected during leukemia development in the E\u03bc-TCL1 transgenic mouse model of CLL","volume":"125","author":"Iacovelli","year":"2015","journal-title":"Blood"},{"key":"2025010703554711900_r75","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.15252\/emmm.201707732","article-title":"Pathogen-specific B-cell receptors drive chronic lymphocytic leukemia by light-chain-dependent cross-reaction with autoantigens","volume":"9","author":"Jim\u00e9nez de Oya","year":"2017","journal-title":"EMBO Mol. Med."},{"key":"2025010703554711900_r76","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1182\/blood-2012-05-431452","article-title":"Delayed development of chronic lymphocytic leukemia in the absence of macrophage migration inhibitory factor","volume":"121","author":"Reinart","year":"2013","journal-title":"Blood"},{"key":"2025010703554711900_r77","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1001\/archinte.165.1.113","article-title":"Coccidioidomycosis in patients with hematologic malignancies","volume":"165","author":"Blair","year":"2005","journal-title":"Arch. Intern. Med."},{"key":"2025010703554711900_r78","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1182\/blood-2015-03-567388","article-title":"Perturbation of the normal immune system in patients with CLL","volume":"126","author":"Forconi","year":"2015","journal-title":"Blood"},{"key":"2025010703554711900_r79","doi-asserted-by":"crossref","first-page":"4180","DOI":"10.4049\/jimmunol.1800241","article-title":"Chronic lymphocytic leukemia-derived IL-10 suppresses antitumor immunity","volume":"200","author":"Alhakeem","year":"2018","journal-title":"J. Immunol."},{"key":"2025010703554711900_r80","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.3390\/ijms21051825","article-title":"Immune response dysfunction in chronic lymphocytic leukemia: dissecting molecular mechanisms and microenvironmental conditions","volume":"21","author":"Arruga","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"2025010703554711900_r81","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1128\/iai.40.3.912-916.1983","article-title":"Inbred mouse strains differ in resistance to lethal Coccidioides immitis infection","volume":"40","author":"Kirkland","year":"1983","journal-title":"Infect. Immun."},{"key":"2025010703554711900_r82","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1128\/IAI.67.6.2916-2919.1999","article-title":"Genes influencing resistance to Coccidioides immitis and the interleukin-10 response map to chromosomes 4 and 6 in mice","volume":"67","author":"Fierer","year":"1999","journal-title":"Infect. Immun."},{"key":"2025010703554711900_r83","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/gene.2008.23","article-title":"Susceptibility to Coccidioides species in C57BL\/6 mice is associated with expression of a truncated splice variant of Dectin-1 (Clec7a)","volume":"9","author":"del Pilar Jim\u00e9nez-A","year":"2008","journal-title":"Genes Immun."},{"key":"2025010703554711900_r84","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3389\/fgene.2020.00483","article-title":"Defining critical genes during spherule remodeling and endospore development in the fungal pathogen, Coccidioides posadasii","volume":"11","author":"Mead","year":"2020","journal-title":"Front. Genet."},{"key":"2025010703554711900_r85","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.semcdb.2018.03.003","article-title":"Pattern recognition receptors in fungal immunity","volume":"89","author":"Patin","year":"2019","journal-title":"Semin. Cell Dev. Biol."},{"key":"2025010703554711900_r86","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.4049\/jimmunol.169.7.3876","article-title":"The \u03b2-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte\/macrophage and neutrophil lineages","volume":"169","author":"Taylor","year":"2002","journal-title":"J. Immunol."},{"key":"2025010703554711900_r87","doi-asserted-by":"crossref","first-page":"205","DOI":"10.4110\/in.2013.13.5.205","article-title":"Dectin-1 stimulation selectively reinforces LPS-driven IgG1 production by mouse B cells","volume":"13","author":"Seo","year":"2013","journal-title":"Immune Netw."},{"key":"2025010703554711900_r88","doi-asserted-by":"crossref","first-page":"e00597-12","DOI":"10.1128\/mBio.00597-12","article-title":"Dectin-1 is required for resistance to coccidioidomycosis in mice","volume":"4","author":"Viriyakosol","year":"2013","journal-title":"MBio"},{"key":"2025010703554711900_r89","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1099\/jmm.0.000138","article-title":"Whole glucan particles as a vaccine against systemic coccidioidomycosis","volume":"64","author":"Clemons","year":"2015","journal-title":"J. Med. Microbiol."},{"key":"2025010703554711900_r90","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.4049\/jimmunol.1900793","article-title":"CARD9-associated Dectin-1 and Dectin-2 are required for protective immunity of a multivalent vaccine against Coccidioides posadasii infection","volume":"204","author":"Campuzano","year":"2020","journal-title":"J. Immunol."},{"key":"2025010703554711900_r91","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1128\/IAI.00047-08","article-title":"Toll-like receptor 9-dependent immune activation by unmethylated CpG motifs in Aspergillus fumigatus DNA","volume":"76","author":"Ramirez-Ortiz","year":"2008","journal-title":"Infect. Immun."},{"key":"2025010703554711900_r92","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1101\/gr.103911.109","article-title":"Population genomic sequencing of Coccidioides fungi reveals recent hybridization and transposon control","volume":"20","author":"Neafsey","year":"2010","journal-title":"Genome Res."},{"key":"2025010703554711900_r93","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/pin.13054","article-title":"Evaluation of clinical formalin-fixed paraffin-embedded tissue quality for targeted-bisulfite sequencing","volume":"71","author":"Ohmomo","year":"2021","journal-title":"Pathol. Int."},{"key":"2025010703554711900_r94","doi-asserted-by":"crossref","first-page":"102673","DOI":"10.1016\/j.dnarep.2019.102673","article-title":"Inflammation-induced DNA damage, mutations and cancer","volume":"83","author":"Kay","year":"2019","journal-title":"DNA Repair (Amst.)"},{"key":"2025010703554711900_r95","doi-asserted-by":"crossref","first-page":"4488","DOI":"10.1182\/blood-2009-12-257758","article-title":"High expression of AID and active class switch recombination might account for a more aggressive disease in unmutated CLL patients: link with an activated microenvironment in CLL disease","volume":"115","author":"Palacios","year":"2010","journal-title":"Blood"},{"key":"2025010703554711900_r96","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1002\/eji.201344421","article-title":"AID induces intraclonal diversity and genomic damage in CD86+ chronic lymphocytic leukemia cells","volume":"44","author":"Huemer","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"2025010703554711900_r97","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/sj.leu.2403294","article-title":"High expression of activation-induced cytidine deaminase (AID) mRNA is associated with unmutated IGVH gene status and unfavourable cytogenetic aberrations in patients with chronic lymphocytic leukaemia","volume":"18","author":"Heintel","year":"2004","journal-title":"Leukemia"},{"key":"2025010703554711900_r98","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.3390\/cancers13112619","article-title":"AID contributes to accelerated disease progression in the TCL1 mouse transplant model for CLL","volume":"13","author":"Schubert","year":"2021","journal-title":"Cancers (Basel)"},{"key":"2025010703554711900_r99","doi-asserted-by":"crossref","first-page":"4802","DOI":"10.1182\/blood-2012-08-449744","article-title":"IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions","volume":"120","author":"Patten","year":"2012","journal-title":"Blood"},{"key":"2025010703554711900_r100","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3109\/08916934.2012.749244","article-title":"Regulation of Aicda expression and AID activity","volume":"46","author":"Zan","year":"2013","journal-title":"Autoimmunity"},{"key":"2025010703554711900_r101","doi-asserted-by":"crossref","first-page":"5300","DOI":"10.4049\/jimmunol.1000574","article-title":"A cyclooxygenase-2\/prostaglandin E2 pathway augments activation-induced cytosine deaminase expression within replicating human B cells","volume":"185","author":"Lee","year":"2010","journal-title":"J. Immunol."},{"key":"2025010703554711900_r102","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1182\/asheducation-2006.1.273","article-title":"Evolving view of the in-vivo kinetics of chronic lymphocytic leukemia B cells","volume":"2006","author":"Chiorazzi","year":"2006","journal-title":"Hematology (Am. Soc. Hematol. Educ. Program)"},{"key":"2025010703554711900_r103","doi-asserted-by":"crossref","first-page":"4832","DOI":"10.1182\/blood-2009-05-219634","article-title":"In vivo intraclonal and interclonal kinetic heterogeneity in B-cell chronic lymphocytic leukemia","volume":"114","author":"Calissano","year":"2009","journal-title":"Blood"},{"key":"2025010703554711900_r104","doi-asserted-by":"crossref","first-page":"84889","DOI":"10.18632\/oncotarget.20031","article-title":"Neutrophils in chronic lymphocytic leukemia are permanently activated and have functional defects","volume":"8","author":"Manukyan","year":"2017","journal-title":"Oncotarget"},{"key":"2025010703554711900_r105","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.18632\/oncotarget.26716","article-title":"Neglected players: tumor associated neutrophils involvement in chronic lymphocytic leukemia progression","volume":"10","author":"Podaza","year":"2019","journal-title":"Oncotarget"},{"key":"2025010703554711900_r106","doi-asserted-by":"crossref","first-page":"5253","DOI":"10.1158\/0008-5472.CAN-15-3486","article-title":"Splenic marginal zone granulocytes acquire an accentuated neutrophil B-cell helper phenotype in chronic lymphocytic leukemia","volume":"76","author":"G\u00e4tjen","year":"2016","journal-title":"Cancer Res."},{"key":"2025010703554711900_r107","doi-asserted-by":"crossref","first-page":"5318","DOI":"10.4049\/jimmunol.1500559","article-title":"\u03b2-Glucan-activated human B lymphocytes participate in innate immune responses by releasing proinflammatory cytokines and stimulating neutrophil chemotaxis","volume":"195","author":"Ali","year":"2015","journal-title":"J. Immunol."},{"key":"2025010703554711900_r108","doi-asserted-by":"crossref","first-page":"73ra19","DOI":"10.1126\/scitranslmed.3001180","article-title":"Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus","volume":"3","author":"Lande","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"2025010703554711900_r109","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.4049\/jimmunol.1700778","article-title":"Netting neutrophils activate autoreactive B cells in lupus","volume":"200","author":"Gestermann","year":"2018","journal-title":"J. Immunol."},{"key":"2025010703554711900_r110","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00262-016-1921-7","article-title":"Neutrophils from chronic lymphocytic leukemia patients exhibit an increased capacity to release extracellular traps (NETs)","volume":"66","author":"Podaza","year":"2017","journal-title":"Cancer Immunol. Immunother."},{"key":"2025010703554711900_r111","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1182\/blood-2006-02-001800","article-title":"Neutrophil-derived APRIL concentrated in tumor lesions by proteoglycans correlates with human B-cell lymphoma aggressiveness. [Published erratum appears in 2007 Blood 110: 1474.]","volume":"109","author":"Schwaller","year":"2007","journal-title":"Blood"},{"key":"2025010703554711900_r112","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/ni.2194","article-title":"B cell-helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen","volume":"13","author":"Puga","year":"2011","journal-title":"Nat. Immunol."},{"key":"2025010703554711900_r113","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1084\/jem.20150577","article-title":"BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis","volume":"213","author":"Parsa","year":"2016","journal-title":"J. Exp. Med."},{"key":"2025010703554711900_r114","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ccr.2004.08.033","article-title":"APRIL promotes B-1 cell-associated neoplasm","volume":"6","author":"Planelles","year":"2004","journal-title":"Cancer Cell"},{"key":"2025010703554711900_r115","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1038\/leu.2015.307","article-title":"CD4+ T cells, but not non-classical monocytes, are dispensable for the development of chronic lymphocytic leukemia in the TCL1-tg murine model","volume":"30","author":"Kocher","year":"2016","journal-title":"Leukemia"},{"key":"2025010703554711900_r116","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.immuni.2012.12.001","article-title":"Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. [Published erratum appears in 2013 Immunity 38: 1073\u20131079.]","volume":"38","author":"Yona","year":"2013","journal-title":"Immunity"},{"key":"2025010703554711900_r117","doi-asserted-by":"crossref","first-page":"12597","DOI":"10.1038\/ncomms12597","article-title":"Regulation of monocyte cell fate by blood vessels mediated by Notch signalling","volume":"7","author":"Gamrekelashvili","year":"2016","journal-title":"Nat. Commun."},{"key":"2025010703554711900_r118","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1084\/jem.20160800","article-title":"CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses","volume":"213","author":"Chong","year":"2016","journal-title":"J. Exp. Med."},{"key":"2025010703554711900_r119","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/ni1309","article-title":"Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2","volume":"7","author":"Serbina","year":"2006","journal-title":"Nat. Immunol."},{"key":"2025010703554711900_r120","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.immuni.2011.02.016","article-title":"Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligands","volume":"34","author":"Shi","year":"2011","journal-title":"Immunity"},{"key":"2025010703554711900_r121","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1172\/JCI124615","article-title":"The role of macrophages in the resolution of inflammation","volume":"129","author":"Watanabe","year":"2019","journal-title":"J. Clin. Invest."},{"key":"2025010703554711900_r122","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.immuni.2017.04.018","article-title":"Genomic characterization of murine monocytes reveals C\/EBP\u03b2 transcription factor dependence of Ly6C\u2212 cells","volume":"46","author":"Mildner","year":"2017","journal-title":"Immunity"},{"key":"2025010703554711900_r123","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1126\/science.1142883","article-title":"Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior","volume":"317","author":"Auffray","year":"2007","journal-title":"Science"},{"key":"2025010703554711900_r124","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.exphem.2020.12.007","article-title":"Chronic lymphocytic leukemia-like monoclonal B-cell lymphocytosis exhibits an increased inflammatory signature that is reduced in early-stage chronic lymphocytic leukemia","volume":"95","author":"Blanco","year":"2021","journal-title":"Exp. Hematol."},{"key":"2025010703554711900_r125","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1038\/s41375-020-0873-2","article-title":"T-cells in chronic lymphocytic leukemia: guardians or drivers of disease?","volume":"34","author":"Roessner","year":"2020","journal-title":"Leukemia"},{"key":"2025010703554711900_r126","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1182\/bloodadvances.2020003795","article-title":"CD4+ T cells sustain aggressive chronic lymphocytic leukemia in E\u03bc-TCL1 mice through a CD40L-independent mechanism","volume":"5","author":"Grioni","year":"2021","journal-title":"Blood Adv."},{"key":"2025010703554711900_r127","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1038\/s41375-021-01217-1","article-title":"Interleukin-10 suppression enhances T-cell antitumor immunity and responses to checkpoint blockade in chronic lymphocytic leukemia","volume":"35","author":"Rivas","year":"2021","journal-title":"Leukemia"},{"key":"2025010703554711900_r128","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.immuni.2018.01.006","article-title":"Interleukin-10 directly inhibits CD8+ T cell function by enhancing N-glycan branching to decrease antigen sensitivity","volume":"48","author":"Smith","year":"2018","journal-title":"Immunity"},{"key":"2025010703554711900_r129","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1158\/1078-0432.CCR-11-2630","article-title":"Expansion of a CD8+PD-1+ replicative senescence phenotype in early stage CLL patients is associated with inverted CD4:CD8 ratios and disease progression","volume":"18","author":"Nunes","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"2025010703554711900_r130","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1182\/blood-2012-09-457531","article-title":"T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production","volume":"121","author":"Riches","year":"2013","journal-title":"Blood"},{"key":"2025010703554711900_r131","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/leu.2011.111","article-title":"Development of CLL in the TCL1 transgenic mouse model is associated with severe skewing of the T-cell compartment homologous to human CLL","volume":"25","author":"Hofbauer","year":"2011","journal-title":"Leukemia"},{"key":"2025010703554711900_r132","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.immuni.2019.06.025","article-title":"Inflammation and cancer: triggers, mechanisms, and consequences","volume":"51","author":"Greten","year":"2019","journal-title":"Immunity"},{"key":"2025010703554711900_r133","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.3324\/haematol.2016.149252","article-title":"\u201cTrained immunity\u201d: consequences for lymphoid malignancies","volume":"101","author":"Stevens","year":"2016","journal-title":"Haematologica"},{"key":"2025010703554711900_r134","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.aay9189","article-title":"The human tumor microbiome is composed of tumor type-specific intracellular bacteria","volume":"368","author":"Nejman","year":"2020","journal-title":"Science"},{"key":"2025010703554711900_r135","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.cell.2019.07.008","article-title":"Tumor microbiome diversity and composition influence pancreatic cancer outcomes","volume":"178","author":"Riquelme","year":"2019","journal-title":"Cell"},{"key":"2025010703554711900_r136","doi-asserted-by":"crossref","first-page":"5524","DOI":"10.1182\/blood-2007-08-109611","article-title":"Borrelia infection and risk of non-Hodgkin lymphoma","volume":"111","author":"Sch\u00f6llkopf","year":"2008","journal-title":"Blood"},{"key":"2025010703554711900_r137","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21037\/aol-20-28","article-title":"Epidemiology of marginal zone lymphoma","volume":"5","author":"Cerhan","year":"2021","journal-title":"Ann. Lymphoma"},{"key":"2025010703554711900_r138","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/joim.12684","article-title":"The aetiology of B-cell lymphoid malignancies with a focus on chronic inflammation and infections","volume":"282","author":"Smedby","year":"2017","journal-title":"J. Intern. Med."},{"key":"2025010703554711900_r139","doi-asserted-by":"crossref","first-page":"578386","DOI":"10.3389\/fimmu.2021.578386","article-title":"Anti-inflammatory and immunomodulatory effects of probiotics in gut inflammation: a door to the body","volume":"12","author":"Cristofori","year":"2021","journal-title":"Front. Immunol."}],"container-title":["ImmunoHorizons"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/immunohorizons\/article-pdf\/7\/5\/333\/60189004\/ih2300013.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/immunohorizons\/article-pdf\/7\/5\/333\/60189004\/ih2300013.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T04:05:05Z","timestamp":1736222705000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/immunohorizons\/article\/7\/5\/333\/7816953"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,1]]},"references-count":139,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5,1]]}},"URL":"https:\/\/doi.org\/10.4049\/immunohorizons.2300013","relation":{},"ISSN":["2573-7732"],"issn-type":[{"type":"electronic","value":"2573-7732"}],"subject":[],"published-other":{"date-parts":[[2023,5]]},"published":{"date-parts":[[2023,5,1]]}}}