{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:35:55Z","timestamp":1778585755979,"version":"3.51.4"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":586,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Recipient T cells can aggravate or regulate lethal and devastating graft-versus-host disease (GVHD) after bone marrow transplantation (BMT). In this context, we have shown before that intestinal immune conditioning with helminths is associated with survival of recipient T cells and Th2 pathway\u2013dependent regulation of GVHD. We investigated the mechanism of survival of recipient T cells and their contribution to GVHD pathogenesis in this helminth infection and BMT model after myeloablative preparation with total body irradiation in mice. Our results indicate that the helminth-induced Th2 pathway directly promotes the survival of recipient T cells after total body irradiation. Th2 cells also directly stimulate recipient T cells to produce TGF-\u03b2, which is required to regulate donor T cell\u2013mediated immune attack of GVHD and can thereby contribute to recipient T cell survival after BMT. Moreover, we show that recipient T cells, conditioned to produce Th2 cytokines and TGF-\u03b2 after helminth infection, are fundamentally necessary for GVHD regulation. Taken together, reprogrammed or immune-conditioned recipient T cells after helminth infection are crucial elements of Th2- and TGF-\u03b2\u2013dependent regulation of GVHD after BMT, and their survival is dependent on cell-intrinsic Th2 signaling.<\/jats:p>","DOI":"10.4049\/immunohorizons.2300021","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T13:36:01Z","timestamp":1686317761000},"page":"442-455","source":"Crossref","is-referenced-by-count":3,"title":["After Bone Marrow Transplantation, the Cell-Intrinsic Th2 Pathway Promotes Recipient T Lymphocyte Survival and Regulates Graft-versus-Host Disease"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7126-3842","authenticated-orcid":false,"given":"Jamie","family":"Truscott","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Carver College of Medicine, University of Iowa , Iowa City, IA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqun","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Carver College of Medicine, University of Iowa , Iowa City, IA"},{"name":"Veterans Administration Medical Center , Iowa City, IA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hope","family":"Fury","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Carver College of Medicine, University of Iowa , Iowa City, IA"},{"name":"Veterans Administration Medical Center , Iowa City, IA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4401-9431","authenticated-orcid":false,"given":"Tyler","family":"Atagozli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Carver College of Medicine, University of Iowa , Iowa City, IA"},{"name":"Veterans Administration Medical Center , Iowa City, IA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Metwali","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Carver College of Medicine, University of Iowa , Iowa City, IA"},{"name":"Veterans Administration Medical Center , Iowa City, IA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiren","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Carver College of Medicine, University of Iowa , Iowa City, IA"},{"name":"Veterans Administration Medical Center , Iowa City, IA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7190-5454","authenticated-orcid":false,"given":"Yue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Carver College of Medicine, University of Iowa , Iowa City, IA"},{"name":"Veterans Administration Medical Center , Iowa City, IA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9220-7049","authenticated-orcid":false,"given":"Robert W","family":"Li","sequence":"additional","affiliation":[{"name":"Animal Parasitic Diseases Laboratory, United States Department of Agriculture, Agricultural Research Service , Beltsville, MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5359-7125","authenticated-orcid":false,"given":"David E","family":"Elliott","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Carver College of Medicine, University of Iowa , Iowa City, IA"},{"name":"Veterans Administration Medical Center , Iowa City, IA"},{"name":"Holden Comprehensive Cancer Center, Carver College of Medicine, University of Iowa , Iowa City, IA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9608-9841","authenticated-orcid":false,"given":"Bruce R","family":"Blazar","sequence":"additional","affiliation":[{"name":"Division of Blood and Marrow Transplantation & Cellular Therapy, Department of Pediatrics, University of Minnesota , Minneapolis, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3451-3421","authenticated-orcid":false,"given":"M Nedim","family":"Ince","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Carver College of Medicine, University of Iowa , Iowa City, IA"},{"name":"Veterans Administration Medical Center , Iowa City, IA"},{"name":"Holden Comprehensive Cancer Center, Carver College of Medicine, University of Iowa , Iowa City, IA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"2025010703561375300_r1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev-immunol-102119-073227","article-title":"Current concepts and advances in graft-versus-host disease immunology","volume":"39","author":"Hill","year":"2021","journal-title":"Annu. 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