{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T17:03:49Z","timestamp":1769274229223,"version":"3.49.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":158,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Perfluorohexane sulfonate (PFHxS) is a member of the per- and polyfluoroalkyls (PFAS) superfamily of molecules, characterized by their fluorinated carbon chains and use in a wide range of industrial applications. PFHxS and perfluorooctane sulfonate are able to accumulate in the environment and in humans with the approximated serum elimination half-life in the range of several years. More recently, some PFAS compounds have also been suggested as potential immunosuppressants. In this study, we analyze immune cell numbers in mice following 28-d repeated oral exposure to potassium PFHxS at 12, 120, 1,200, and 12,000 ng\/kg\/d, with resulting serum levels ranging up to \u223c1,600 ng\/ml, approximating ranges found in the general population and at higher levels in PFAS workers. The immunosuppressant cyclophosphamide was analyzed as a positive control. B cells, T cells, and granulocytes from the bone marrow, liver, spleen, lymph nodes, and thymus were evaluated. We found that at these exposures, there was no effect of PFHxS on major T or B cell populations, macrophages, dendritic cells, basophils, mast cells, eosinophils, neutrophils, or circulating Ab isotypes. By contrast, mice exposed to cyclophosphamide exhibited depletion of several granulocyte and T and B cell populations in the thymus, bone marrow, and spleen, as well as reductions in IgG1, IgG2b, IgG2c, IgG3, IgE, and IgM. These data indicate that exposures of up to 12,000 ng\/kg of PFHxS for 28 d do not affect immune cell numbers in naive mice, which provides valuable information for assessing the risks and health influences of exposures to this compound.<\/jats:p>","DOI":"10.4049\/immunohorizons.2300049","type":"journal-article","created":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T12:29:57Z","timestamp":1723033797000},"page":"538-549","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Perfluorohexane Sulfonate Exposure on Immune Cell Populations in Naive Mice"],"prefix":"10.1093","volume":"8","author":[{"given":"Timothy M","family":"Pierpont","sequence":"first","affiliation":[{"name":"Department of Microbiology & Immunology, Cornell University , Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4360-0378","authenticated-orcid":false,"given":"Jessica","family":"Elmore","sequence":"additional","affiliation":[{"name":"Department of Microbiology & Immunology, Cornell University , Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amie","family":"Redko","sequence":"additional","affiliation":[{"name":"Department of Microbiology & Immunology, Cornell University , Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0536-5829","authenticated-orcid":false,"given":"Orchi","family":"Anannya","sequence":"additional","affiliation":[{"name":"Department of Microbiology & Immunology, Cornell University , Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Imbiakha","sequence":"additional","affiliation":[{"name":"Department of Microbiology & Immunology, Cornell University , Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3380-2527","authenticated-orcid":false,"given":"Katelyn","family":"O\u2019Hare","sequence":"additional","affiliation":[{"name":"Department of Microbiology & Immunology, Cornell University , Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3608-0148","authenticated-orcid":false,"given":"Alanis","family":"Villanueva","sequence":"additional","affiliation":[{"name":"Department of Microbiology & Immunology, Cornell University , Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7854-1809","authenticated-orcid":false,"given":"Sasha","family":"Anronikov","sequence":"additional","affiliation":[{"name":"Department of Microbiology & Immunology, Cornell University , Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8474-2252","authenticated-orcid":false,"given":"Narda","family":"Bondah","sequence":"additional","affiliation":[{"name":"Department of Microbiology & Immunology, Cornell University , Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4282-7199","authenticated-orcid":false,"given":"Sue","family":"Chang","sequence":"additional","affiliation":[{"name":"3M Company , St. Paul, MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1852-9511","authenticated-orcid":false,"given":"Julie","family":"Sahler","sequence":"additional","affiliation":[{"name":"Department of Microbiology & Immunology, Cornell University , Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4968-3415","authenticated-orcid":false,"given":"Avery","family":"August","sequence":"additional","affiliation":[{"name":"Department of Microbiology & Immunology, Cornell University , Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,7]]},"reference":[{"key":"2025010608555157300_r1","first-page":"e06223-391","article-title":"Scientific opinion on the risk to human health related to the presence of perfluoroalkyl substances in food","volume":"18","author":"Schrenk","year":"2020","journal-title":"EFSA J."},{"key":"2025010608555157300_r2","article-title":"Toxicological Profile for Perfluoroalkyls","author":"Centers for Disease Control and Prevention","year":"2021"},{"key":"2025010608555157300_r3","article-title":"Per- and Polyfluoroalkyl Substances (PFAS)","author":"U.S. Environmental Protection Agency"},{"key":"2025010608555157300_r4","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1136\/oemed-2017-104651","article-title":"Half-lives of PFOS, PFHxS and PFOA after end of exposure to contaminated drinking water","volume":"75","author":"Li","year":"2018","journal-title":"Occup. Environ. Med."},{"key":"2025010608555157300_r5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.chemosphere.2014.09.005","article-title":"Historical usage of aqueous film forming foam: a case study of the widespread distribution of perfluoroalkyl acids from a military airport to groundwater, lakes, soils and fish","volume":"129","author":"Filipovic","year":"2015","journal-title":"Chemosphere"},{"key":"2025010608555157300_r6","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.reprotox.2011.07.002","article-title":"Comparative pharmacokinetics of perfluorooctanesulfonate (PFOS) in rats, mice, and monkeys","volume":"33","author":"Chang","year":"2012","journal-title":"Reprod. 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