{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:06:47Z","timestamp":1793639207506,"version":"4.5.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":494,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Organ supply remains inadequate to meet the needs of many patients who could benefit from allotransplantation. Xenotransplantation, the use of animals as organ donors, provides an opportunity to alleviate this challenge. Pigs are widely accepted as the ideal organ donor, but humans and nonhuman primates have strong humoral immune responses to porcine tissue. Although carbohydrate xenoantigens have been studied intensively, the primate Ab response also targets class I and class II swine leukocyte Ags (SLAs). Human Abs that recognize HLAs can cross-react with SLA molecules because epitopes can be shared across species. However, \u223c15% of people may also exhibit Abs toward class II SLAs despite lacking Abs that also recognize class II HLAs. Here, we extend these studies to better understand human Ab responses toward class I SLAs. When tested against a panel of 18 unique class I SLA proteins, 14 of 52 sera samples collected from patients in need of an organ transplant contained Abs that bound class I SLAs. Class I SLA\u2013reactive sera may contain IgM only, IgG, only, or IgM and IgG capable of recognizing the pig proteins. The presence of class I HLA\u2013reactive Abs was not essential to generating anti\u2013class I SLA Ig. Last, anti\u2013class I SLA reactivity varied by serum; some recognized a single SLA allele, whereas others recognized multiple class I SLA proteins.<\/jats:p>","DOI":"10.4049\/immunohorizons.2300056","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T13:35:49Z","timestamp":1694784949000},"page":"619-625","source":"Crossref","is-referenced-by-count":22,"title":["Patients on the Transplant Waiting List Have Anti-Swine Leukocyte Antigen Class I Antibodies"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8827-2806","authenticated-orcid":false,"given":"Zheng-Yu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Miami School of Medicine , Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0250-3675","authenticated-orcid":false,"given":"Luz","family":"Reyes","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Miami School of Medicine , Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7460-5294","authenticated-orcid":false,"given":"Jose","family":"Estrada","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Miami School of Medicine , Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Burlak","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Miami School of Medicine , Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Novara","family":"Gennuso","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Miami School of Medicine , Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mosely O","family":"Tector","sequence":"additional","affiliation":[{"name":"Makana Therapeutics , Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5520-2537","authenticated-orcid":false,"given":"Sam","family":"Ho","sequence":"additional","affiliation":[{"name":"Gift of Hope Organ and Tissue Donor Network , Itasca, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Tector","sequence":"additional","affiliation":[{"name":"Makana Therapeutics , Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Joseph","family":"Tector","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Miami School of Medicine , Miami, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,15]]},"reference":[{"key":"2025010703564431300_r1","doi-asserted-by":"crossref","first-page":"278","DOI":"10.34067\/KID.0007152021","article-title":"Current status of renal xenotransplantation and next steps","volume":"4","author":"Tector","year":"2023","journal-title":"Kidney360"},{"key":"2025010703564431300_r2","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1097\/SLA.0000000000002977","article-title":"Xenoantigen deletion and chemical immunosuppression can prolong renal xenograft survival","volume":"268","author":"Adams","year":"2018","journal-title":"Ann. 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