{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:22:11Z","timestamp":1788790931702,"version":"build-2803163510"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":311,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>T cell immunity, including CD4+ and CD8+ T cell immunity, is critical to host immune responses to infection. Transcriptomic analyses of both CD4+ and CD8+ T cells of C57BL\/6 mice show high expression the gene encoding embigin, Emb, which encodes a transmembrane glycoprotein. Moreover, we found that lung CD4+ Th17 tissue-resident memory T cells of C57BL\/6 mice also express high levels of Emb. However, deletion of Emb in \u03b1\u03b2 T cells of C57BL\/6 mice revealed that Emb is dispensable for thymic T cell development, generation of lung Th17 tissue-resident memory T cells, tissue-resident memory T cell homing to the lung, experimental autoimmune encephalitis, as well as clearance of pulmonary viral or fungal infection. Thus, based on this study, embigin appears to play a minor role if any in \u03b1\u03b2 T cell development or \u03b1\u03b2 T cell effector functions in C57BL\/6 mice.<\/jats:p>","DOI":"10.4049\/immunohorizons.2300083","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T15:28:07Z","timestamp":1709738887000},"page":"242-253","source":"Crossref","is-referenced-by-count":3,"title":["Embigin Is Highly Expressed on CD4+ and CD8+ T Cells but Is Dispensable for Several T Cell Effector Responses"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6464-8450","authenticated-orcid":false,"given":"Haoran","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Medicine, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine , New Orleans, LA"},{"name":"Department of Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine , New Orleans, LA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0680-390X","authenticated-orcid":false,"given":"Naoki","family":"Iwanaga","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine , New Orleans, LA"},{"name":"Department of Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine , New Orleans, LA"},{"name":"Department of Respiratory Medicine, Nagasaki University Hospital , Nagasaki ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3302-0759","authenticated-orcid":false,"given":"Alexis R","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine , New Orleans, LA"},{"name":"Department of Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine , New Orleans, LA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1539-6765","authenticated-orcid":false,"given":"Andy R","family":"Ridley","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine , New Orleans, LA"},{"name":"Department of Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine , New Orleans, LA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan D","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine , New Orleans, LA"},{"name":"Department of Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine , New Orleans, LA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4835-4358","authenticated-orcid":false,"given":"Michaela J","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Tulane University School of Medicine , New Orleans, LA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1256-6410","authenticated-orcid":false,"given":"Dereck","family":"Pociask","sequence":"additional","affiliation":[{"name":"Department of Medicine, Tulane University School of Medicine , New Orleans, LA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5151-6304","authenticated-orcid":false,"given":"Jay K","family":"Kolls","sequence":"additional","affiliation":[{"name":"Department of Medicine, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine , New Orleans, LA"},{"name":"Department of Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine , New Orleans, LA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,6]]},"reference":[{"key":"2025010608550729100_r1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.4161\/cam.5.1.13491","article-title":"Adhesion molecules: key players in mesenchymal stem cell-mediated immunosuppression","volume":"5","author":"Ren","year":"2011","journal-title":"Cell. 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