{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:01:45Z","timestamp":1793322105846,"version":"4.5.0"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":250,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Our previous work demonstrated that basophils regulate a suite of malaria phenotypes, including intestinal mastocytosis and permeability, the immune response to infection, gametocytemia, and parasite transmission to the malaria mosquito Anopheles stephensi. Given that activated basophils are primary sources of the regulatory cytokines IL-4 and IL-13, we sought to examine the contributions of these mediators to basophil-dependent phenotypes in malaria. We generated mice with basophils depleted for IL-4 and IL-13 (baso IL-4\/IL-13 (\u2212)) and genotype controls (baso IL-4\/IL-13 (+)) by crossing mcpt8-Cre and Il4\/Il13fl\/fl mice and infected them with Plasmodium yoelii yoelii 17XNL. Conditional deletion was associated with ileal mastocytosis and mast cell (MC) activation, increased intestinal permeability, and increased bacterial 16S levels in blood, but it had no effect on neutrophil activation, parasitemia, or transmission to A. stephensi. Increased intestinal permeability in baso IL-4\/IL-13 (\u2212) mice was correlated with elevated plasma eotaxin (CCL11), a potent eosinophil chemoattractant, and increased ileal MCs, proinflammatory IL-17A, and the chemokines MIP-1\u03b1 (CCL3) and MIP-1\u03b2 (CCL4). Blood bacterial 16S copies were positively but weakly correlated with plasma proinflammatory cytokines IFN-\u03b3 and IL-12p40, suggesting that baso IL-4\/IL-13 (\u2212) mice failed to control bacterial translocation into the blood during malaria infection. These observations suggest that basophil-derived IL-4 and IL-13 do not contribute to basophil-dependent regulation of parasite transmission, but these cytokines do orchestrate protection of intestinal barrier integrity after P. yoelii infection. Specifically, basophil-dependent IL-4\/IL-13 control MC activation and prevent infection-induced intestinal barrier damage and bacteremia, perhaps via regulation of eosinophils, macrophages, and Th17-mediated inflammation.<\/jats:p>","DOI":"10.4049\/immunohorizons.2300084","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T13:45:50Z","timestamp":1716471950000},"page":"371-383","source":"Crossref","is-referenced-by-count":7,"title":["Basophil-Derived IL-4 and IL-13 Protect Intestinal Barrier Integrity and Control Bacterial Translocation during Malaria"],"prefix":"10.1093","volume":"8","author":[{"given":"Nora","family":"C\u00e9spedes","sequence":"first","affiliation":[{"name":"Department of Entomology, Plant Pathology and Nematology, University of Idaho , Moscow, ID"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail M","family":"Fellows","sequence":"additional","affiliation":[{"name":"Department of Entomology, Plant Pathology and Nematology, University of Idaho , Moscow, ID"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erinn L","family":"Donnelly","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Idaho , Moscow, ID"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah L","family":"Kaylor","sequence":"additional","affiliation":[{"name":"Department of Entomology, Plant Pathology and Nematology, University of Idaho , Moscow, ID"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor A","family":"Coles","sequence":"additional","affiliation":[{"name":"Department of Entomology, Plant Pathology and Nematology, University of Idaho , Moscow, ID"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Wild","sequence":"additional","affiliation":[{"name":"Department of Entomology, Plant Pathology and Nematology, University of Idaho , Moscow, ID"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Dobson","sequence":"additional","affiliation":[{"name":"Department of Entomology, Plant Pathology and Nematology, University of Idaho , Moscow, ID"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2476-6233","authenticated-orcid":false,"given":"Joseph","family":"Schauer","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy and Clinical Immunology, University of California , Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1193-5875","authenticated-orcid":false,"given":"Judy","family":"Van de Water","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Allergy and Clinical Immunology, University of California , Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5047-4683","authenticated-orcid":false,"given":"Shirley","family":"Luckhart","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Idaho , Moscow, ID"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"key":"2025010608551845600_r1","author":"World Health Organization","year":"2022"},{"key":"2025010608551845600_r2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1741-7015-12-31","article-title":"Invasive bacterial co-infection in African children with Plasmodium falciparum malaria: a systematic review","volume":"12","author":"Church","year":"2014","journal-title":"BMC Med."},{"key":"2025010608551845600_r3","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1093\/infdis\/jiv596","article-title":"Numerical distributions of parasite densities during asymptomatic malaria","volume":"213","author":"Imwong","year":"2016","journal-title":"J. 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