{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:11:17Z","timestamp":1792174277172,"version":"4.4.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":135,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute for Deafness and Communication Disorders","doi-asserted-by":"publisher","award":["R01DC019965"],"award-info":[{"award-number":["R01DC019965"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chronic suppurative otitis media (CSOM) is a neglected disease that afflicts 330 million people worldwide and is the most common cause of permanent hearing loss among children in the developing world. Previously, we discovered that outer hair cell (OHC) loss occurred in the basal turn of the cochlea and that macrophages are the major immune cells associated with OHC loss in CSOM. Macrophage-associated cytokines are upregulated. Specifically, CCL-2, an important member of the MCP family, is elevated over time following middle ear infection. CCR2 is a common receptor of the MCP family and the unique receptor of CCL2. CCR2 knockout mice (CCR2\u2212\/\u2212) have been used extensively in studies of monocyte activation in neurodegenerative diseases. In the present study, we investigated the effect of CCR2 deletion on the cochlear immune response and OHC survival in CSOM. The OHC survival rate was 84 \u00b1 12.5% in the basal turn of CCR2+\/+ CSOM cochleae, compared with was 63 \u00b1 19.9% in the basal turn of CCR2\u2212\/\u2212 CSOM cochleae (p \u2264 0.05). Macrophage numbers were significantly reduced in CCR2\u2212\/\u2212 CSOM cochleae compared with CCR2+\/+ CSOM cochleae (p \u2264 0.001). In addition, CCL7 was upregulated, whereas IL-33 was downregulated, in CCR2\u2212\/\u2212 CSOM cochleae. Finally, the permeability of the blood\u2013labyrinth barrier in the stria vascularis remained unchanged in CCR2\u2212\/\u2212 CSOM compared with CCR2+\/+ CSOM. Taken together, the data suggest that CCR2 plays a protective role through cochlear macrophages in the CSOM cochlea.<\/jats:p>","DOI":"10.4049\/immunohorizons.2400064","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T15:10:04Z","timestamp":1726153804000},"page":"688-694","source":"Crossref","is-referenced-by-count":3,"title":["Chemokine Receptor CCR2 Is Protective toward Outer Hair Cells in Chronic Suppurative Otitis Media"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3865-669X","authenticated-orcid":false,"given":"Ankur","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, School of Medicine, Stanford University , Palo Alto, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5982-247X","authenticated-orcid":false,"given":"Viktoria","family":"Schiel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, School of Medicine, Stanford University , Palo Alto, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritwija","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, School of Medicine, Stanford University , Palo Alto, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1528-1821","authenticated-orcid":false,"given":"Kourosh","family":"Eftekharian","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, School of Medicine, Stanford University , Palo Alto, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2530-6375","authenticated-orcid":false,"given":"Anping","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, School of Medicine, Stanford University , Palo Alto, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter L","family":"Santa Maria","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2013 Head and Neck Surgery, School of Medicine, Stanford University , Palo Alto, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"key":"2025011406165151200_r1","first-page":"495","article-title":"The global burden of disease in 1990: summary results, sensitivity analysis and future directions","volume":"72","author":"Murray","year":"1994","journal-title":"Bull. 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