{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:31:40Z","timestamp":1791048700585,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Resistance to leishmaniasis in C57BL\/6 mice depends on Th1\/Tc1 cells. BALB\/c mice preferentially develop Th2 immunity and succumb to infection. We now assessed the role of IL-17 in cutaneous leishmaniasis. During the course of Leishmania major infection, BALB\/c CD4 cells and neutrophils produced increased amounts of IL-17 as compared with cells from C57BL\/6 mice. This increase was associated with significantly increased IL-23 release from L. major-infected BALB\/c dendritic cells (DC), whereas IL-6 and TGF-\u03b21 production by BALB\/c and C57BL\/6 DC were comparable. Interestingly, lesion sizes in infected IL-17-deficient BALB\/c mice were dramatically smaller and failed to progress as compared with those in control mice. Similar amounts of IL-4, IL-10, and IFN-\u03b3 were produced by T cells from IL-17-deficient mice and control mice consistent with development of Th2-predominant immunity in all animals. Improved disease outcome was associated with decreased CXCL2-accumulation in lesion sites and decreased neutrophil immigration into lesions of infected IL-17-deficient mice confirming prior observations that enhanced neutrophil recruitment contributes to disease susceptibility in BALB\/c mice. This study excludes an important facilitating role for IL-17 in Th1\/Th2 development in L. major-infected BALB\/c mice, and suggests that IL-23 production by L. major-infected DC maintains IL-17+ cells that influence disease progression via regulation of neutrophil recruitment.<\/jats:p>","DOI":"10.4049\/jimmunol.0713598","type":"journal-article","created":{"date-parts":[[2009,2,20]],"date-time":"2009-02-20T17:41:32Z","timestamp":1235151692000},"page":"3039-3046","source":"Crossref","is-referenced-by-count":198,"title":["IL-17 Promotes Progression of Cutaneous Leishmaniasis in Susceptible Mice"],"prefix":"10.1093","volume":"182","author":[{"given":"Susanna","family":"Lopez Kostka","sequence":"first","affiliation":[{"name":"Department of Dermatology, Johannes Gutenberg-University , Mainz,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Dinges","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Johannes Gutenberg-University , Mainz,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Griewank","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Johannes Gutenberg-University , Mainz,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Iwakura","sequence":"additional","affiliation":[{"name":"Center for Experimental Medicine, Institute of Medical Science, University of Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark C","family":"Udey","sequence":"additional","affiliation":[{"name":"Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"von Stebut","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Johannes Gutenberg-University , Mainz,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,3,1]]},"reference":[{"key":"2026012807034432200_R1","first-page":"225","article-title":"Re-examination of the immunosuppressive mechanisms mediating non-cure of Leishmania infection in mice.","volume-title":"Immunol. 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Immunol.","year":"2004"},{"key":"2026012807034432200_R18","first-page":"1693","article-title":"Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte\/macrophage colony-stimulating factor.","volume-title":"J. Exp. Med.","year":"1992"},{"key":"2026012807034432200_R19","first-page":"3800","article-title":"Antigen-pulsed epidermal Langerhans cells protect susceptible mice from infection with the intracellular parasite Leishmania major.","volume-title":"Eur. J. Immunol.","year":"1998"},{"key":"2026012807034432200_R20","first-page":"1547","article-title":"Uptake of Leishmania major amastigotes results in activation and interleukin 12 release from murine skin-derived dendritic cells: implications for the initiation of anti-Leishmania immunity. J.","volume-title":"Exp. Med.","year":"1998"},{"key":"2026012807034432200_R21","first-page":"3498","article-title":"Leishmania major-infected murine Langerhans cell-like dendritic cells from susceptible mice release IL-12 after infection and vaccinate against experimental cutaneous leishmaniasis.","volume-title":"Eur. J. Immunol.","year":"2000"},{"key":"2026012807034432200_R22","first-page":"1708","article-title":"IL-1\u03b1 and TNF-\u03b1 are required for IL-12-induced development of Th1 cells producing high levels of IFN-\u03b3 in BALB\/c but not C57BL\/6 mice.","volume-title":"J. Immunol.","year":"1998"},{"key":"2026012807034432200_R23","first-page":"4278","article-title":"Impaired expression of inflammatory cytokines and chemokines at early stages of infection with Leishmania amazonensis.","volume-title":"Infect. Immun.","year":"2003"},{"key":"2026012807034432200_R24","first-page":"1390","article-title":"TGF-\u03b2 and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell-mediated pathology.","volume-title":"Nat. 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Immunol.","year":"2002"},{"key":"2026012807034432200_R33","first-page":"145","article-title":"The role of polymorphonuclear leukocytes in the resistance to cutaneous leishmaniasis.","volume-title":"Immunol. Lett.","year":"1998"},{"key":"2026012807034432200_R34","first-page":"109","article-title":"The involvement of neutrophils in the resistance to Leishmania major infection in susceptible but not in resistant mice.","volume-title":"Parasitol. Int.","year":"2005"},{"key":"2026012807034432200_R35","first-page":"143","article-title":"Complement C3 is required for the progression of cutaneous lesions and neutrophil attraction in Leishmania major infection.","volume-title":"Med. Microbiol. Immunol.","year":"2005"},{"key":"2026012807034432200_R36","first-page":"135","article-title":"Differences in the onset of the inflammatory response to cutaneous leishmaniasis in resistant and susceptible mice.","volume-title":"J. 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