{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:00:58Z","timestamp":1787320858101,"version":"build-2736575974"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We previously reported that rOv-ASP-1, a recombinant Onchocerca volvulus activation associated protein-1, was a potent adjuvant for recombinant protein or synthetic peptide-based Ags. In this study, we further evaluated the adjuvanticity of rOv-ASP-1 and explored its mechanism of action. Consistently, recombinant full-length spike protein of SARS-CoV or its receptor-binding domain in the presence of rOv-ASP-1 could effectively induce a mixed but Th1-skewed immune response in immunized mice. It appears that rOv-ASP-1 primarily bound to the APCs among human PBMCs and triggered Th1-biased proinflammatory cytokine production probably via the activation of monocyte-derived dendritic cells and the TLR, TLR2, and TLR4, thus suggesting that rOv-ASP-1 is a novel potent innate adjuvant.<\/jats:p>","DOI":"10.4049\/jimmunol.0800531","type":"journal-article","created":{"date-parts":[[2009,3,19]],"date-time":"2009-03-19T16:57:19Z","timestamp":1237481839000},"page":"4005-4016","source":"Crossref","is-referenced-by-count":36,"title":["Recombinant\n                    <i>Ov<\/i>\n                    -ASP-1, a Th1-Biased Protein Adjuvant Derived from the Helminth\n                    <i>Onchocerca volvulus<\/i>\n                    , Can Directly Bind and Activate Antigen-Presenting Cells"],"prefix":"10.1093","volume":"182","author":[{"given":"Yuxian","family":"He","sequence":"first","affiliation":[{"name":"Lindsley F. Kimball Research Institute, New York Blood Center , New York, NY 10065"},{"name":"Institute of Pathogen Biology, Chinese Academy of Medical Sciences , Beijing,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie J","family":"Barker","sequence":"additional","affiliation":[{"name":"iQur, Southampton General Hospital , Southampton,","place":["UK"]},{"name":"Liver Group, Division of IIR Southampton University, Southampton General Hospital , Southampton,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angus J","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Lindsley F. Kimball Research Institute, New York Blood Center , New York, NY 10065"},{"name":"iQur, Southampton General Hospital , Southampton,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yu","sequence":"additional","affiliation":[{"name":"Lindsley F. Kimball Research Institute, New York Blood Center , New York, NY 10065"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Cao","sequence":"additional","affiliation":[{"name":"Lindsley F. Kimball Research Institute, New York Blood Center , New York, NY 10065"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Li","sequence":"additional","affiliation":[{"name":"Lindsley F. Kimball Research Institute, New York Blood Center , New York, NY 10065"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjit","family":"Parhar","sequence":"additional","affiliation":[{"name":"Lindsley F. Kimball Research Institute, New York Blood Center , New York, NY 10065"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Heck","sequence":"additional","affiliation":[{"name":"Lindsley F. Kimball Research Institute, New York Blood Center , New York, NY 10065"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Molecular Parasitology, Humboldt University ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas T","family":"Golenbock","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, University of Massachusetts Medical School , Worcester, MA 01655"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibo","family":"Jiang","sequence":"additional","affiliation":[{"name":"Lindsley F. Kimball Research Institute, New York Blood Center , New York, NY 10065"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan A","family":"Libri","sequence":"additional","affiliation":[{"name":"iQur, Southampton General Hospital , Southampton,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda E","family":"Semper","sequence":"additional","affiliation":[{"name":"iQur, Southampton General Hospital , Southampton,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"iQur, Southampton General Hospital , Southampton,","place":["UK"]},{"name":"Center for Hepatology, University College London , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Lustigman","sequence":"additional","affiliation":[{"name":"Lindsley F. Kimball Research Institute, New York Blood Center , New York, NY 10065"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,4,1]]},"reference":[{"key":"2025032622395343100_R1","first-page":"1626","article-title":"TLR11 activation of dendritic cells by a protozoan profilin-like protein.","volume-title":"Science","year":"2005"},{"key":"2025032622395343100_R2","first-page":"53","article-title":"Ov-ASP-1, the Onchocerca volvulus homologue of the activation associated secreted protein family is immunostimulatory and can induce protective anti-larval immunity.","volume-title":"Parasite Immunol.","year":"2004"},{"key":"2025032622395343100_R3","first-page":"7454","article-title":"Helminth antigens modulate TLR-initiated dendritic cell activation.","volume-title":"J. 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