{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:11:59Z","timestamp":1792127519394,"version":"4.4.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>B lymphocytes play a fundamental role in the development of IgE-dependent allergic immune reactions. Upon appropriate activation, IgE class switch recombination is initiated in B cells, followed by terminal differentiation to IgE-secreting plasmablasts. This process is controlled by different nuclear receptors, including receptors for vitamin D, retinoids, and peroxisome proliferator-activated receptor-\u03b3 ligands. In this study, we show constitutive expression of the nuclear liver X receptor (LXR)\u03b1 and LXR\u03b2 in peripheral human B cells. Activation of LXRs reduced secreted IgE (\u221268% \u00b1 11) in CD40 and IL-4 activated B cells. The production of other isotypes, including IgG, IgM, IgA and B cell homeostatic parameters were not significantly altered by LXR activation. We identified inhibitory action of LXR activation on IgE production involving reduced phosphorylation of JNK and increased membrane CD23 expression (38% \u00b1 11). The biological significance of our findings was validated by showing that systemic treatment of type I-sensitized BALB\/c mice with LXR ligands reduced the serum concentrations of Ag-specific IgE in a dose-dependent manner (maximum, \u221252% \u00b1 14). Thus, our data indicates that LXRs are involved in the control of IgE secretion by differentiating B cells.<\/jats:p>","DOI":"10.4049\/jimmunol.0801804","type":"journal-article","created":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T01:07:38Z","timestamp":1240276058000},"page":"5276-5282","source":"Crossref","is-referenced-by-count":57,"title":["Liver X Receptors Control IgE Expression in B Cells"],"prefix":"10.1093","volume":"182","author":[{"given":"Guido","family":"Heine","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy, Charit\u00e9 Universit\u00e4tsmedizin Berlin , Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Dahten","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Charit\u00e9 Universit\u00e4tsmedizin Berlin , Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Hilt","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Charit\u00e9 Universit\u00e4tsmedizin Berlin , Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Ernst","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Charit\u00e9 Universit\u00e4tsmedizin Berlin , Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Milovanovic","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Charit\u00e9 Universit\u00e4tsmedizin Berlin , Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Charit\u00e9 Universit\u00e4tsmedizin Berlin , Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margitta","family":"Worm","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Charit\u00e9 Universit\u00e4tsmedizin Berlin , Berlin,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,5,1]]},"reference":[{"key":"2026012807024133600_R1","first-page":"607","article-title":"Liver X receptors as integrators of metabolic and inflammatory signaling.","volume-title":"J. 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