{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:28:43Z","timestamp":1791088123981,"version":"4.1.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Coinhibitory pathways are thought to act in later stages of an adaptive immune response, but whether coinhibition contributes to early innate immunity is unclear. We show that engagement of the newly discovered coinhibitory receptor B and T lymphocyte attenuator (BTLA) by herpesvirus entry mediator (HVEM) is critical for negatively regulating early host immunity against intracellular bacteria. Both HVEM\u2212\/\u2212 and BTLA\u2212\/\u2212, but not LIGHT\u2212\/\u2212, mice are more resistant to listeriosis compared with wild-type mice, and blockade of the BTLA pathway promotes, while engagement inhibits, early bacterial clearance. Differences in bacterial clearance were seen as early as 1 day postinfection, implicating the initial innate response. Therefore, innate cell function in BTLA\u2212\/\u2212 mice was studied. We show that innate cells from BTLA\u2212\/\u2212 mice secrete significantly more proinflammatory cytokines upon stimulation with heat-killed Listeria. These results provide the first evidence that a coinhibitory pathway plays a critical role in regulating early host innate immunity against infection.<\/jats:p>","DOI":"10.4049\/jimmunol.0801866","type":"journal-article","created":{"date-parts":[[2009,7,8]],"date-time":"2009-07-08T20:36:40Z","timestamp":1247085400000},"page":"1946-1951","source":"Crossref","is-referenced-by-count":45,"title":["B and T Lymphocyte Attenuator Tempers Early Infection Immunity"],"prefix":"10.1093","volume":"183","author":[{"given":"Yonglian","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Chicago , Chicago, IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas K","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Chicago , Chicago, IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J","family":"Ruddy","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Chicago , Chicago, IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mendy L","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Chicago , Chicago, IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youjin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Chicago , Chicago, IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Chicago , Chicago, IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth M","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Pathology and Center for Immunology, Washington University , St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Pfeffer","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf , D\u00fcsseldorf,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieping","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Johns Hopkins University , Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Kaye","sequence":"additional","affiliation":[{"name":"Department of Immunology, the Scripps Research Institute , La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang-Xin","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Chicago , Chicago, IL 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,8,1]]},"reference":[{"key":"2026012811252623300_R1","first-page":"116","article-title":"The B7-CD28 superfamily.","volume-title":"Nat. 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