{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:31:44Z","timestamp":1791311504736,"version":"4.3.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>IFN-\u03b3 plays a critical role during the immune response to infection with Listeria monocytogenes. Early in the innate response NK cells are thought to be a primary source of IFN-\u03b3; however, protection can be mediated by the presence of significant numbers of primed IFN-\u03b3-secreting CD8+ T cells. In this report, we examined the early response to Listeria and found that 18 h after infection spleens contain CD11b+, Gr-1high, or Ly6G+ cells that produce significant IFN-\u03b3. Morphological analysis of sorted Gr-1highIFN-\u03b3+ and Gr-1lowIFN-\u03b3+ or Ly6G+IFN-\u03b3+ cells confirmed that these cells were neutrophils. The importance of IFN-\u03b3 production by these cells was further tested using adoptive transfer studies. Transfer of purified neutrophils from Ifng+\/+ mice led to increased bacterial clearance in Ifng\u2212\/\u2212 mice. Transfer of Ifng\u2212\/\u2212 neutrophils provided no such protection. We conclude that neutrophils are an early source of IFN-\u03b3 during Listeria infection and are important in providing immune protection.<\/jats:p>","DOI":"10.4049\/jimmunol.0802410","type":"journal-article","created":{"date-parts":[[2009,5,19]],"date-time":"2009-05-19T17:00:29Z","timestamp":1242752429000},"page":"7069-7073","source":"Crossref","is-referenced-by-count":53,"title":["Identification of an IFN-\u03b3-Producing Neutrophil Early in the Response to\n                    <i>Listeria monocytogenes<\/i>\n                    \u00a0"],"prefix":"10.1093","volume":"182","author":[{"given":"Jiyi","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Washington University School of Medicine , St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Washington University School of Medicine , St. Louis, MO 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,6,1]]},"reference":[{"key":"2026012806293489600_R1","first-page":"27","article-title":"Murine listeriosis as a model of antimicrobial defense.","volume-title":"Immunol. 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