{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:56:10Z","timestamp":1790913370307,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>IL-31 is a recently identified cytokine made predominantly by CD4+ Th2 cells and its receptor, IL-31R, is expressed by a number of cell types including monocytes, epithelial cells, and T cells. Originally identified as a potential mediator of inflammation in the skin, we recently reported a novel function for endogenous IL-31R interactions in limiting type 2 inflammation in the lung. However, whether IL-31-IL-31R interactions regulate immunity or inflammation at other mucosal sites, such as the gut, is unknown. In this study, we report a regulatory role for IL-31-IL-31R interactions in the intestine following infection with the gastrointestinal helminth Trichuris muris, immunity to which is critically dependent on CD4+ Th2 cells that produce IL-4 and IL-13. IL-31R\u03b1 was constitutively expressed in the colon and exposure to Trichuris induced the expression of IL-31 in CD4+ T cells. In response to Trichuris infection, IL-31R\u03b1\u2212\/\u2212 mice exhibited increased Th2 cytokine responses in the mesenteric lymph nodes and elevated serum IgE and IgG1 levels compared with wild type mice. IL-31R\u03b1\u2212\/\u2212 mice also displayed enhanced goblet cell hyperplasia and a marked increase in secretion of goblet cell-derived resistin-like molecule \u03b2 into the intestinal lumen. Consistent with their exacerbated type 2 inflammatory responses, IL-31R\u03b1\u2212\/\u2212 mice exhibited accelerated expulsion of Trichuris with significantly decreased worm burdens compared with their wild type counterparts early following infection. Collectively, these data provide the first evidence of a function for IL-31-IL-31R interactions in limiting the magnitude of type 2 inflammatory responses within the intestine.<\/jats:p>","DOI":"10.4049\/jimmunol.0802459","type":"journal-article","created":{"date-parts":[[2009,5,4]],"date-time":"2009-05-04T16:48:20Z","timestamp":1241455700000},"page":"6088-6094","source":"Crossref","is-referenced-by-count":46,"title":["IL-31-IL-31R Interactions Limit the Magnitude of Th2 Cytokine-Dependent Immunity and Inflammation following Intestinal Helminth Infection"],"prefix":"10.1093","volume":"182","author":[{"given":"Jacqueline G","family":"Perrigoue","sequence":"first","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colby","family":"Zaph","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia , Vancouver,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Guild","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurong","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Artis","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,5,15]]},"reference":[{"key":"2026012806321058600_R1","first-page":"159","article-title":"Molecular phylogeny within type I cytokines and their cognate receptors.","volume-title":"Immunity","year":"2003"},{"key":"2026012806321058600_R2","first-page":"16831","article-title":"A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5.","volume-title":"J. 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