{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:19:07Z","timestamp":1790864347325,"version":"4.1.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2009,3,1]],"date-time":"2009-03-01T00:00:00Z","timestamp":1235865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Previous studies have shown that IL-17 is a strong proinflammatory cytokine and that IL-17-producing autoreactive T cells play a major role in the pathogenesis of autoimmune diseases. In a previous study, we showed that injection of experimental autoimmune uveitis-susceptible mice with anti-IL-17 Abs blocked subsequent disease development. To determine whether administration of IL-17 to experimental autoimmune uveitis-susceptible Lewis rats and B10RIII mice injected with disease-inducing peptides enhanced disease susceptibility, we injected the recipient animals with various doses of human rIL-17 (hIL-17). Unexpectedly, the treated animals showed significant amelioration of disease; in addition, both the intensity of the autoreactive response and cytokine production by the autoreactive T cells induced by immunization with uveitogenic peptides were significantly decreased. Our results show that IL-17 has anti-inflammatory activity and that this cytokine can suppress the development of autoimmune disease.<\/jats:p>","DOI":"10.4049\/jimmunol.0802487","type":"journal-article","created":{"date-parts":[[2009,2,20]],"date-time":"2009-02-20T22:41:32Z","timestamp":1235169692000},"page":"3183-3190","source":"Crossref","is-referenced-by-count":84,"title":["Anti-Inflammatory Role of IL-17 in Experimental Autoimmune Uveitis"],"prefix":"10.1093","volume":"182","author":[{"given":"Yan","family":"Ke","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville , KY 40202"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Liu","sequence":"additional","affiliation":[{"name":"Southern BioTech , Birmingham AL 35209"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Qiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Southern BioTech , Birmingham AL 35209"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Cui","sequence":"additional","affiliation":[{"name":"Doheny Eye Institute, Keck School of Medicine, University of Southern California , Los Angeles, CA 90033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry J","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville , KY 40202"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville , KY 40202"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deming","family":"Sun","sequence":"additional","affiliation":[{"name":"Doheny Eye Institute, Keck School of Medicine, University of Southern California , Los Angeles, CA 90033"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,3,1]]},"reference":[{"key":"2025032622235371700_R1","first-page":"2271","article-title":"Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides.","volume-title":"J. 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