{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:49:23Z","timestamp":1790682563497,"version":"4.1.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic infection results in continuous formation and exhaustion of effector CD8 T cells and in failure of memory CD8 T cell development. Expression of CD70 and other molecules that provide costimulation to T cells is maintained during chronic infection. To analyze the impact of constitutive CD70-driven costimulation, we generated transgenic mice expressing CD70 specifically on T cells. We show that CD70 promoted accumulation of CD8 T cells with characteristics strikingly similar to exhausted effector CD8 T cells found during chronic infection. CD70 on T cells provided costimulation that enhanced primary CD8 T cell responses against influenza. In contrast, memory CD8 T cell maintenance and protection against secondary challenge with influenza was impaired. Interestingly, we found no effect on the formation of either effector or memory CD4 T cells. We conclude that constitutive expression of CD70 is sufficient to deregulate the CD8 T cell differentiation pathway of acute infection reminiscent of events in chronic infection.<\/jats:p>","DOI":"10.4049\/jimmunol.0802809","type":"journal-article","created":{"date-parts":[[2009,4,21]],"date-time":"2009-04-21T01:07:38Z","timestamp":1240276058000},"page":"5352-5362","source":"Crossref","is-referenced-by-count":46,"title":["Protective CD8 T Cell Memory Is Impaired during Chronic CD70-Driven Costimulation"],"prefix":"10.1093","volume":"182","author":[{"given":"Klaas P J M","family":"van Gisbergen","sequence":"first","affiliation":[{"name":"Department of Experimental Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald W","family":"van Olffen","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josine","family":"van Beek","sequence":"additional","affiliation":[{"name":"Department of Immunopathology, Sanquin Research at CLB and Landsteiner Laboratory , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koenraad F","family":"van der Sluijs","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Academic Medical Center , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Arens","sequence":"additional","affiliation":[{"name":"Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology , La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn A","family":"Nolte","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene A","family":"van Lier","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,5,1]]},"reference":[{"key":"2026012807025186600_R1","first-page":"93","article-title":"Development, trafficking, and function of memory T-cell subsets.","volume-title":"Immunol. 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