{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:35:07Z","timestamp":1791128107774,"version":"4.1.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Effector CD8 T cell recruitment into the skin in response to Ag challenge requires prior CXCL1\/KC-directed neutrophil infiltration. Mechanisms inducing CXCL1 production and the dynamics of neutrophil-CD8 T cell interactions during elicitation of Ag-specific responses in the skin were investigated. CXCL1 and CXCL2\/MIP-2 were produced within 3\u20136 h of Ag challenge at 10-fold higher levels in skin challenge sites of Ag-sensitized vs nonsensitized mice. In the challenge sites of sensitized mice this production decreased at 6\u20139 h postchallenge to near the levels observed in skin challenge sites of nonsensitized mice but rose to a second peak 12 h after challenge. The elevated early neutrophil chemoattractant production at 3\u20136 h after skin challenge of sensitized animals required both IFN-\u03b3 and IL-17, produced by distinct populations of Ag-primed CD8 T cells in response to Ag challenge. Although induced by the Ag-primed CD8 T cells, the early CXCL1 and CXCL2 production was accompanied by neutrophil but not CD8 T cell infiltration into the skin Ag challenge site. Infiltration of the CD8 T cells into the challenge site was not observed until 18\u201324 h after challenge. These results demonstrate an intricate series of early interactions between Ag-specific and innate immune components that regulate the sequential infiltration of neutrophils and then effector T cells into the skin to mediate an immune response.<\/jats:p>","DOI":"10.4049\/jimmunol.0802830","type":"journal-article","created":{"date-parts":[[2009,5,4]],"date-time":"2009-05-04T16:48:20Z","timestamp":1241455700000},"page":"5949-5959","source":"Crossref","is-referenced-by-count":78,"title":["CD8 T Cells Producing IL-17 and IFN-\u03b3 Initiate the Innate Immune Response Required for Responses to Antigen Skin Challenge"],"prefix":"10.1093","volume":"182","author":[{"given":"Danielle D","family":"Kish","sequence":"first","affiliation":[{"name":"Department of Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Immunology"},{"name":"Department of Pathology, Case Western Reserve University School of Medicine , Cleveland, OH 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L","family":"Fairchild","sequence":"additional","affiliation":[{"name":"Department of Immunology"},{"name":"Glickman Urological Institute, Cleveland Clinic Foundation , Cleveland, OH 44195"},{"name":"Department of Pathology, Case Western Reserve University School of Medicine , Cleveland, OH 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,5,15]]},"reference":[{"key":"2026012806305142700_R1","first-page":"97","article-title":"Interleukin-8 and related chemotactic cytokines-CXC and CC chemokines.","volume-title":"Adv. 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