{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:19:56Z","timestamp":1790702396351,"version":"4.1.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Type I IFNs (IFN-\u03b1\/\u03b2) have only recently gained considerable attention as immunomodulators in nonviral infectious diseases. IFN-\u03b2 has been shown to protect, in a NO-dependent manner, against murine Old World leishmaniasis caused by Leishmania major, but data in New World leishmaniasis are lacking. We found that IFN-\u03b2 dose-dependently increases parasite burden in Leishmania amazonensis- as well as Leishmania braziliensis-infected human macrophages, independent of endogenous or exogenous NO. However, IFN-\u03b2 significantly reduced superoxide release in Leishmania-infected as well as uninfected human macrophages. This decrease in superoxide production was paralleled by a significant IFN-\u03b2-mediated increase in superoxide dismutase 1 (SOD1) protein levels. Additionally, IFN-\u03b2 inhibition of leishmanicidal activity was mimicked by SOD1 and antagonized by either pharmacological or small interfering RNA-mediated inhibition of SOD1. Finally, pronounced SOD1 expression in situ was demonstrated in biopsies from New World cutaneous leishmaniasis patients. These findings reveal a hitherto unknown IFN-\u03b2\/SOD1 axis in Leishmania infection and suggest that inhibition of SOD-associated pathways could serve as strategy in the treatment of L. amazonensis as well as L. braziliensis infection, major human pathogens.<\/jats:p>","DOI":"10.4049\/jimmunol.0802860","type":"journal-article","created":{"date-parts":[[2009,2,9]],"date-time":"2009-02-09T12:02:33Z","timestamp":1234180953000},"page":"2525-2531","source":"Crossref","is-referenced-by-count":82,"title":["IFN-\u03b2 Impairs Superoxide-Dependent Parasite Killing in Human Macrophages: Evidence for a Deleterious Role of SOD1 in Cutaneous Leishmaniasis"],"prefix":"10.1093","volume":"182","author":[{"given":"Ricardo","family":"Khouri","sequence":"first","affiliation":[{"name":"Laboratory of Immunoregulation and Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Bafica","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology and Infectious Diseases, Microbiology and Parasitology Department, Federal University of Santa Catarina , Florian\u00f3polis-Santa Catarina,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria da Purifica\u00e7\u00e3o Pereira","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation and Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almerio","family":"Noronha","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation and Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Kolb","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Unit\u00e9 Mixte de Recherche en Sant\u00e9 872 , Centre de Recherche des Cordeliers"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juana","family":"Wietzerbin","sequence":"additional","affiliation":[{"name":"INSERM, Unit\u00e9 365 , Institut Curie, Paris,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldina","family":"Barral","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoparasitology, Centro de Pesquisa Gon\u00e7alo Moniz, Funda\u00e7\u00e3o Oswaldo Cruz , Salvador-Bahia,","place":["Brazil"]},{"name":"Institute for Investigation in Immunology-iii , S\u00e3o Paulo,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoel","family":"Barral-Netto","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation and Microbiology"},{"name":"Institute for Investigation in Immunology-iii , S\u00e3o Paulo,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Van Weyenbergh","sequence":"additional","affiliation":[{"name":"Laboratory of Immunoregulation and Microbiology"},{"name":"Institute for Investigation in Immunology-iii , S\u00e3o Paulo,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,2,15]]},"reference":[{"key":"2026012806235602100_R1","first-page":"305","article-title":"Leishmaniasis: current situation and new perspectives.","volume-title":"Comp. 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